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Association Between the Cool Temperature-dependent Suppression of Colonic Peristalsis and Transient Receptor Potential Melastatin 8 Activation in Both a Randomized Clinical Trial and an Animal Model

Sugino S, Inoue K, Kobayashi R, Hirose R, Doi T, Harusato A, Dohi O, Yoshida N, Uchiyama K, Ishikawa T, Takagi T, Yasuda H, Konishi H, Hirai Y, Mizushima K, Naito Y, Tsuji T, Okuda T, Kagawa K, Tominaga M, Itoh Y

  • KMID: 2534327
  • J Neurogastroenterol Motil.
  • 2022 Oct;28(4):693-705.
  • doi: 10.5056/jnm21198
Background/Aims Several studies have assessed the effect of cool temperature on colonic peristalsis. Transient receptor potential melastatin 8 (TRPM8) is a temperature-sensitive ion channel activated by mild cooling expressed in the...
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Blue Laser Imaging, Blue Light Imaging, and Linked Color Imaging for the Detection and Characterization of Colorectal Tumors

Yoshida N, Dohi O, Inoue K, Yasuda R, Murakami T, Hirose R, Inoue K, Naito Y, Inada Y, Ogiso K, Morinaga Y, Kishimoto , Rani RA, Itoh Y

A laser endoscopy system was developed in 2012. The system allows blue laser imaging (BLI), BLI-bright, and linked color imaging (LCI) to be performed as modes of narrow-band light observation;...
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Differences in Prevalence of Lymphovascular Invasion among Early Gastric Cancers between Korea and Japan

Lee SY, Yoshida N, Dohi O, Lee SP, Ichikawa D, Kim JH, Sung IK, Park HS, Otsuji E, Itoh Y, Shim CS, Han HS, Kishimoto , Naito Y

BACKGROUND/AIMS: The presence of invasion is a diagnostic criterion of early gastric cancer (EGC) in Korea, whereas diagnosis in Japan is based on enlarged nuclei and prominent nucleoli. Moreover, the...
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