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Role of Autophagy in Granulocyte-Colony Stimulating Factor Induced Anti-Apoptotic Effects in Diabetic Cardiomyopathy

Shen GY, Shin JH, Song YS, Joo HW, Park IH, Seong JH, Shin NK, Lee AH, Cho YJ, Lee Y, Lim YH, Kim H, Kim KS

Background: We previously, reported that granulocyte-colony stimulating factor (G-CSF) reduces cardiomyocyte apoptosis in diabetic cardiomyopathy. However, the underlying mechanisms are not yet fully understood. Therefore, we investigated whether the mechanisms...
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Epidemiology, Pathophysiology, Diagnosis and Treatment of Heart Failure in Diabetes

Park JJ

The cardiovascular disease continuum begins with risk factors such as diabetes mellitus (DM), progresses to vasculopathy and myocardial dysfunction, and finally ends with cardiovascular death. Diabetes is associated with a...
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Association between Non-Alcoholic Steatohepatitis and Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Mellitus

Lee H, Kim G, Choi YJ, Huh BW, Lee BW, Kang ES, Cha BS, Lee EJ, Lee Yh, Huh KB

Background: Impaired diastolic heart function has been observed in persons with non-alcoholic fatty liver disease (NAFLD) and/or with type 2 diabetes mellitus (T2DM). However, it is unclear whether NAFLD fibrotic...
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Role of MicroRNA-34a in Anti-Apoptotic Effects of Granulocyte-Colony Stimulating Factor in Diabetic Cardiomyopathy

Park IH, Song YS, Joo HW, Shen GY, Seong JH, Shin NK, Cho YJ, Lee Y, Shin JH, Lim YH, Kim H, Kim KS

BACKGROUND: Recent studies have shown that microRNAs (miRNAs) are involved in the process of cardiomyocyte apoptosis. We have previously reported that granulocyte-colony stimulating factor (G-CSF) ameliorated diastolic dysfunction and attenuated...
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Mitochondrial Mechanisms in Diabetic Cardiomyopathy

Gollmer J, Zirlik A, Bugger H

Mitochondrial medicine is increasingly discussed as a promising therapeutic approach, given that mitochondrial defects are thought to contribute to many prevalent diseases and their complications. In individuals with diabetes mellitus...
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Diabetes-Related Cardiac Dysfunction

Williams L, Nye BG, Wende AR

The proposal that diabetes plays a role in the development of heart failure is supported by the increased risk associated with this disease, even after correcting for all other known...
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Diabetic cardiomyopathy: where we are and where we are going

Lee WS, Kim J

The global burden of diabetes mellitus and its related complications are currently increasing. Diabetes mellitus affects the heart through various mechanisms including microvascular impairment, metabolic disturbance, subcellular component abnormalities, cardiac...
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Diabetic Cardiomyopathy; Summary of 41 years

Yilmaz S, Canpolat U, Aydogdu S, Abboud HE

Patients with diabetes have an increased risk for development of cardiomyopathy, even in the absence of well known risk factors like coronary artery disease and hypertension. Diabetic cardiomyopathy was first...
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Diabetic Cardiomyopathy and Its Prevention by Nrf2: Current Status

Chen J, Zhang Z, Cai L

Diabetic cardiomyopathy (DCM), as one of the major cardiac complications in diabetic patients, is known to related with oxidative stress that is due to a severe imbalance between reactive oxygen...
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Evaluation of Cardiac Functions with Tissue Doppler Imaging in Prediabetic Subjects

Kanat M, Vardi S, Arinc H, Gunduz H, Erdem A, Karagoz Y

BACKGROUND AND OBJECTIVES: The aim of the present study was to evaluate left ventricle systolic and diastolic function, using tissue Doppler echocardiography (TDE), in relation to blood glucose status in...
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