- Differential effects of various dietary proteins on dextran sulfate sodiuminduced colitis in mice
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Ahn E, Jeong H, Kim E
- KMID: 2536505
- Nutr Res Pract.
- 2022 Dec;16(6):700-715.
- doi: 10.4162/nrp.2022.16.6.700
BACKGROUND/OBJECTIVES: Chronic colitis is a risk factor for colorectal cancer (CRC) development in both animals and humans. Previously, we reported that a diet rich in protein (with casein as the... -
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- Effects of Dextran Sulfate Sodium-Induced Ulcerative Colitis on the Disposition of Tofacitinib in Rats
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Bae SH, Kim HS, Choi HG, Chang SY, Kim SH
- KMID: 2534700
- Biomol Ther.
- 2022 Nov;30(6):510-519.
- doi: 10.4062/biomolther.2022.049
Tofacitinib, a Janus kinase 1 and 3 inhibitor, is mainly metabolized by CYP3A1/2 and CYP2C11 in the liver. The drug has been approved for the chronic treatment of severe ulcerative... -
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- Treatment with Extracellular Vesicles from Giardia lamblia Alleviates Dextran Sulfate Sodium-Induced Colitis in C57BL/6 Mice
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Kim HJ, Lee YJ, Back SO, Cho SH, Lee HI, Lee MR
- KMID: 2535997
- Korean J Parasitol.
- 2022 Oct;60(5):309-315.
- doi: 10.3347/kjp.2022.60.5.309
Inflammatory bowel disease (IBD) is a chronic and recurrent illness of the gastrointestinal tract. Treatment of IBD traditionally involves the use of aminosalicylic acid and steroids, while these drugs has... -
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- Potential Role of Heme Oxygenase-1 in the Resolution of Experimentally Induced Colitis through Regulation of Macrophage Polarization
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Gwak SY, Kim SJ, Park J, Kim SH, Joe Y, Lee HN, Kim W, Muna IA, Na HK, Chung HT, Surh YJ
- KMID: 2526998
- Gut Liver.
- 2022 Mar;16(2):246-258.
- doi: 10.5009/gnl210058
Background/Aims: Heme oxygenase-1 (HO-1) plays a central role in cellular defense against inflammatory insults, and its induction in macrophages potentiates their efferocytic activity. In this study, we explored the potential... -
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- Epithelial Cell-specific Deletion of Microsomal Prostaglandin E Synthase-1 Does Not Influence Colon Tumor Development in Mice
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Nakanishi M, Rosenberg DW
- KMID: 2524125
- J Cancer Prev.
- 2021 Dec;26(4):304-308.
- doi: 10.15430/JCP.2021.26.4.304
Activation of the COX-2/microsomal prostaglandin E synthase-1 (mPGES-1)/prostaglandin E 2 (PGE 2 ) signaling axis is a hallmark of many cancers, including colorectal cancer, prompting the implementation of prevention strategies... -
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- Induction of colorectal carcinogenesis in the C57BL/6J and A/J mouse strains with a reduced DSS dose in the AOM/DSS model
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Arnesen H, Müller MHB, Aleksandersen M, Østby GC, Carlsen H, Paulsen JE, Boysen P
- KMID: 2521036
- Lab Anim Res.
- 2021 Sep;37(3):213-222.
- doi: 10.1186/s42826-021-00096-y
Background: Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide and thus mouse models of CRC are of significant value to study the pathogenesis. The Azoxymethane/Dextran sulfate... -
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- Inflammatory responses of C57BL/6NKorl mice to dextran sulfate sodium-induced colitis: comparison between three C57BL/6 N sub-strains
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Kim SH, Kwon D, Son SW, Jeong TB, Lee S, Kwak JH, Cho JY, Hwang DY, Seo MS, Kim KS, Jung YS
- KMID: 2514398
- Lab Anim Res.
- 2021 Mar;37(1):67-73.
- doi: 10.1186/s42826-021-00084-2
Background: Inflammatory bowel disease (IBD), including both Crohn’s disease and ulcerative colitis, are chronic human diseases that are challenging to cure and are often unable to be resolved. The inbred... -
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- A glycolipid adjuvant, 7DW8-5, provides a protective effect against colonic inflammation in mice by the recruitment of CD1d-restricted natural killer T cells
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Lee C, Hong SN, Kim YH
- KMID: 2508566
- Intest Res.
- 2020 Oct;18(4):402-411.
- doi: 10.5217/ir.2019.00132
Background/Aims: The modulation of CD1d-restricted natural killer T (NKT) cells by glycolipids has been considered as a potential therapy against immunologic diseases, including inflammatory bowel disease. A recently identified a... -
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- Anti-inflammatory effects of mulberry twig extracts on dextran sulfate sodium-induced colitis mouse model
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Cui X, Kim E
- KMID: 2444937
- J Nutr Health.
- 2019 Apr;52(2):139-148.
- doi: 10.4163/jnh.2019.52.2.139
PURPOSE: Ulcerative colitis is a common inflammatory bowel disease. Prolonged colitis can be a risk factor for the development of colorectal cancer. Mulberry twig (MT, Sangzhi), a dry branch of... -
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- Comparative Effects of Curcumin and Tetrahydrocurcumin on Dextran Sulfate Sodium-induced Colitis and Inflammatory Signaling in Mice
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Yang JY, Zhong X, Kim SJ, Kim DH, Kim HS, Lee JS, Yum HW, Lee J, Na HK, Surh YJ
- KMID: 2416948
- J Cancer Prev.
- 2018 Mar;23(1):18-24.
- doi: 10.15430/JCP.2018.23.1.18
BACKGROUND: Curcumin, a yellow ingredient of turmeric (Curcuma longa Linn, Zingiberaceae), has long been used in traditional folk medicine in the management of inflammatory disorders. Although curcumin has been reported... -
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- Induction of Indoleamine 2,3-dioxygenase by Pre-treatment with Poly(I:C) May Enhance the Efficacy of MSC Treatment in DSS-induced Colitis
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Ryu DB, Lim JY, Lee SE, Park G, Min CK
- KMID: 2362800
- Immune Netw.
- 2016 Dec;16(6):358-365.
- doi: 10.4110/in.2016.16.6.358
Mesenchymal stem cells (MSCs) have been used experimentally for treating inflammatory disorders, partly owing to their immunosuppressive properties. The goal of the study was to determine whether TLR ligands can... -
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- Long-Term Effects of Bone Marrow-Derived Mesenchymal Stem Cells in Dextran Sulfate Sodium-Induced Murine Chronic Colitis
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Lee HJ, Oh SH, Jang HW, Kwon JH, Lee KJ, Kim CH, Park SJ, Hong SP, Cheon JH, Kim TI, Kim WH
- KMID: 2411969
- Gut Liver.
- 2016 May;10(3):412-419.
- doi: 10.5009/gnl15229
BACKGROUND/AIMS: Bone marrow-derived mesenchymal stem cells (BM-MSCs) have shown beneficial effects in experimental colitis models, but the underlying mechanisms are not fully understood. We investigated the long-term effects of BM-MSCs,... -
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- Trichinella spiralis Infection Suppressed Gut Inflammation with CD4+CD25+Foxp3+ T Cell Recruitment
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Cho MK, Park MK, Kang SA, Choi SH, Ahn SC, Yu HS
- KMID: 1792137
- Korean J Parasitol.
- 2012 Dec;50(4):385-390.
In order to know the effect of pre-existing Trichinella spiralis infection on experimentally induced intestinal inflammation and immune responses, we induced colitis in T. spiralis-infected mice and observed the severity... -
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- A Study of Immunohistochemical Change of the Experimental Ulcerative Colitis induced by DSS
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Park IS
- KMID: 1510226
- Korean J Anat.
- 2006 Dec;39(6):523-531.
The experimental ulcerative colitis is chronic inflammatory illness in colon, which didn't reveal the exact reason and pathophysiological situation. In this study, the colitis was induced by 3% DSS (mw;... -
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- Fine Structure of Goblet Cell Regeneration on Experimental Colitis Induced by Dextran Sulfate Sodium
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Park IS
- KMID: 2092884
- Korean J Anat.
- 2006 Oct;39(5):417-424.
Ulcerative colitis is recognized as important causes of gastrointestinal diseases in children and adults. I observed the fine structural changes of goblet cell regeneration after experimental ulcerative colitis induced by dextran sulfate... -
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- Histological Study of Experimental Colitis Induced by Dextran Sulfate Sodium
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Park IS
- KMID: 2224479
- Korean J Anat.
- 2006 Feb;39(1):27-33.
Inflamatory bowel disease is the general medical terminology on chronic inflammatory illness of unknown origin, but it is considered that environmental, genetical, immunological factors may develop this chronic disease. I... -
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- Prophylactic Effect of Lactobacillus GG in Animal Colitis and Its Effect on Cytokine Secretion and Mucin Gene Expressions
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Moon G, Myung SJ, Jeong JY, Yang SK, Cho YK, Lee SM, Chang HS, Byeon JS, Lee YJ, Lee GH, Hong WS, Kim JH, Min YI, Kim JS
- KMID: 772632
- Korean J Gastroenterol.
- 2004 Apr;43(4):234-245.
BACKGROUND/AIMS: Lactobacillus rhamnosus GG (LGG) has been used in acute colitis treatment. However, it is unclear whether the LGG prevents chronic colitis. The aim of this study was to... -
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