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Heart Transplant Immunosuppression Strategies at Cedars-Sinai Medical Center

Chang DH, Youn JC, Dilibero D, Patel JK, Kobashigawa JA

Heart transplant is the optimal treatment for selected patients with end-stage heart failure. Immunosuppression after heart transplantation has significantly reduced the incidence of rejection and improved patient outcomes with the...
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Comparison of one-bag and multibag desensitization protocols for the prevention of rituximab hypersensitivity

Kim HH, Moon M, Cho MK, Ahn KM, Chung S, Kang DY, Lee SY, Cho SH, Kang HR

Purpose: Rituximab is prone to infusion-related reactions, which commonly requires desensitization to maintain its administration. Conventional desensitization protocols are using multistep infusion by diluting solutions. However, the process of diluting...
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Allergen-Specific Immunotherapy Against Allergic Respiratory Diseases

Kang SY, Yang MS, Lee SM, Lee SP

Allergen-specific immunotherapy (AIT) can alter the natural course of an allergic disease. It is widely held that the efficacy of a given therapeutic modality should be proven by well-designed double-blind...
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Efficacy of Allergen Immunotherapy for Allergic Asthma in Real World Practice

Rhyou HI, Nam YH

PURPOSE: Allergen immunotherapy (AIT) induces immunological tolerance, and there is increasing evidence of the clinical efficacy of AIT in the treatment of allergic asthma. However, the optimal parameters for asthma...
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Desensitization in HLA Incompatible Transplantation

Park BG

In terminally ill patients, organ transplantation could be recommended as the treatment of choice. In Korea, living donor liver or kidney transplantation is much more frequent than deceased donor transplantation...
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A case of rapid desensitization for rituximab-induced delayed hypersensitivity reaction

Lee SH, Lee JH, Kim NH, Kang DY, Lee JY, Chung SJ, Oh JH, Kang HR

Rituximab is a monoclonal antibody used for the treatment of B-cell malignancies, including diffuse large B-cell lymphoma. Infusion-related hypersensitivity reactions to rituximab is well known, and delayed hypersensitivity reactions to...
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Desensitization for Allergic Reactions to Chemotherapy

Hong DI

Drug desensitization is procedure by which patients can be tolerized to medications that have previously induced hypersensitivity reactions. Initially used in treating hypersensitivity reactions to antibiotics, desensitization is now frequently...
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Successful treatment of early acute antibody-mediated rejection in an human leukocyte antigen-incompatible and ABO-incompatible living-donor kidney transplant patient

Gang S, Han A, Min SI, Ha J, Yang J

For successful human leukocyte antigen-incompatible (HLAi) or ABO-incompatible (ABOi) living-donor kidney transplantations (LDKTs), pretransplant desensitization is essential; however, early antibody-mediated rejection (ABMR) remains the most important complication after HLAi or...
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Safety of Ultra-rush Schedule of Subcutaneous Allergen Immunotherapy With House Dust Mite Extract Conducted in an Outpatient Clinic in Patients With Atopic Dermatitis and Allergic Rhinitis

Lee SH, Kim ME, Shin YS, Ye YM, Park HS, Nahm DH

PURPOSE: Ultra-rush schedule of subcutaneous allergen immunotherapy (UR-SCIT) administering maximum maintenance dose of allergen extract within one day can save time and effort for allergen immunotherapy in patients with allergic...
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Interleukin-10 is increased in successful drug desensitization regardless of the hypersensitivity reaction type

Gelincik A, Demir S, Şen F, Bozbey UH, Olgaç M, Ünal D, Çolakoğlu B, Aktaş EC, Deniz G, Büyüköztürk S

BACKGROUND: Little is known about the mechanism of desensitization in hypersensitivity drug reactions. OBJECTIVE: The aim of this study was to evaluate the effects of drug desensitization on some cytokine levels...
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Cow's milk oral immunotherapy in real life: 8-year long-term follow-up study

Mota I, Piedade S, Gaspar A, Benito-Garcia F, Sampaio G, Borrego LM, Morais-Almeida M

BACKGROUND: Oral immunotherapy (OIT) has been recognized as a promising treatment for severe and long-lasting cow's milk (CM) allergy. Once maintenance has been achieved, patients should maintain daily intake of...
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Samter's Triad: State of the Art

Kim SD, Cho KS

Samter's triad (ST) is a well-known disease characterized by the triad of bronchial asthma, nasal polyps, and aspirin intolerance. Over the past few years, a rapid development in the knowledge...
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Successful desensitization to fluconazole induced delayed hypersensitivity: A case report

Heo YJ, Park SW, Lee KS, Kang HR, Kwon JW

Fluconazole is a triazole-based first-generation antifungal agent and has excellent effects on candidiasis and cryptococcosis. Hypersensitivity has been reported as a side effect of fluconazole. A 76-year-old female patient used...
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Case Report of Kidney Paired Donation (KPD) with Desensitization: the Strategy and Experience of 3-Way KPD in Samsung Medical Center

Oh D, Kang ES, Yu S, Chun K, Huh W, Jang HR, Cho CW, Lee N, Lee KW, Park H, Park JB, Kim SJ

As the need for the organ donation increases, strategies to increase kidney transplantation (KT) through expanded living donation have become essential. These include kidney paired donation (KPD) programs and desensitization...
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A case of oral desensitization for hypersensitivity to exogenous progesterone

Kim YC, Choi KH, Kang DY, Sohn KH, Cho SH, Min KU, Kang HR

Hypersensitivity reaction to progesterone is a rare pathologic condition which consists of autoimmune response to endogenous progesterone, known as autoimmune progesterone dermatitis, and hypersensitivity reaction to exogenous progestogen. We report...
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Successful desensitization of pemetrexed-induced anaphylaxis in a patient with malignant mesothelioma

Youk J, Park H, Jin KN, Moon HJ, Yang MS, Kim KH, Kim JS

No abstract available.
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Molecular Signature That Determines the Acute Tolerance of G Protein-Coupled Receptors

Min C, Zhang X, Zheng M, Sun N, Acharya S, Zhang X, Kim KM

Desensitization and acute tolerance are terms used to describe the attenuation of receptor responsiveness by prolonged or intermittent exposure to an agonist. Unlike desensitization of G protein-coupled receptors (GPCRs), which...
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Successful desensitization of a patient with albumin hypersensitivity

Jung SY, Choi YJ, Lee SH, Kang HR, Suh DI

There have been few cases of albumin hypersensitivity reported, and there is limited information on this condition. When a patient is anaphylactic to a certain drug and no alternative drug...
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Fatal Invasive Pulmonary Aspergillosis after Combined Induction with Rituximab and Antithymocyte Globulin for Kidney Transplantation in a Sensitized Recipient, and Early Rejection Therapy with Plasmapheresis and Low-dose Immunoglobulin

Jeong DW, Lee SH, Moon JY, Kim YG, Lee YH, Kim K, Park H, Joo SH

A high degree of sensitization to human leukocyte antigen requires more intensive induction therapy; however, this increases vulnerability to opportunistic infections following kidney transplantation. Although recent studies have suggested that...
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Eye Movement Desensitization and Reprocessing to Facilitate Posttraumatic Growth: A Prospective Clinical Pilot Study on Ferry Disaster Survivors

Jeon SW, Han C, Choi J, Ko YH, Yoon HK, Kim YK

OBJECTIVE: The purpose of this study was to investigate the therapeutic effects of eye movement desensitization and reprocessing (EMDR) on post-traumatic growth (PTG). METHODS: This study was conducted using a sample...
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