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MiR-155 modulates the inflammatory phenotype of intestinal myofibroblasts by targeting SOCS1 in ulcerative colitis

Pathak S, Grillo AR, Scarpa M, Brun P, D'Inca R, Nai L, Banerjee A, Cavallo D, Barzon L, Palu G, Sturniolo , Buda A, Castagliuolo I

Abnormal levels of microRNA (miR)-155, which regulate inflammation and immune responses, have been demonstrated in the colonic mucosa of patients with inflammatory bowel diseases (IBD), although its role in disease...
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Chronic stress enhances progression of periodontitis via alpha1-adrenergic signaling: a potential target for periodontal disease therapy

Lu H, Xu M, Wang F, Liu S, Gu J, Lin S

This study assessed the roles of chronic stress (CS) in the stimulation of the sympathetic nervous system and explored the underlying mechanisms of periodontitis. Using an animal model of periodontitis...
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Immune Response and the Tumor Microenvironment: How They Communicate to Regulate Gastric Cancer

Lee K, Hwang H, Nam KT

  • KMID: 1774539
  • Gut Liver.
  • 2014 Mar;8(2):131-139.
Gastric cancer is the second most common cause of cancer-related death in the world. A growing body of evidence indicates that inflammation is closely associated with the initiation, progression, and...
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Protective Role of Purified Cysteine Proteinases against Fasciola gigantica Infection in Experimental Animals

EL-Ahwany , Rabia I, Nagy F, Zoheiry M, Diab T, Zada S

Fascioliasis is one of the public health problems in the world. Cysteine proteinases (CP) released by Fasciola gigantica play a key role in parasite feeding, migration through host tissues, and...
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Bilirubin protects grafts against nonspecific inflammation-induced injury in syngeneic intraportal islet transplantation

Zhu H, Wang J, Jiang H, Ma Y, Pan S, Reddy S, Sun X

Nonspecific inflammatory response is the major cause for failure of islet grafts at the early phase of intraportal islet transplantation (IPIT). Bilirubin, a natural product of heme catabolism, has displayed...
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Modulation of protective immunity against herpes simplex virus via mucosal genetic co-transfer of DNA vaccine with beta2-adrenergic agonist

Kim SB, Han YW, Rahman MM, Kim SJ, Yoo DJ, Kang SH, Kim K, Eo SK

Cholera toxin, which has been frequently used as mucosal adjuvant, leads to an irreversible activation of adenylyl cyclase, thereby accumulating cAMP in target cells. Here, it was assumed that beta2-adrenergic...
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Differential regulation of inducible nitric oxide synthase and cyclooxygenase-2 expression by superoxide dismutase in lipopolysaccharide stimulated RAW 264.7 cells

Lee JA, Song HY, Ju SM, Lee SJ, Kwon HJ, Eum WS, Jang SH, Choi SY, Park J

Inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) have been known to be involved in various pathophysiological processes such as inflammation. This study was performed to determine the regulatory...
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Selective addition of CXCR3+CCR4-CD4+ Th1 cells enhances generation of cytotoxic T cells by dendritic cells in vitro

Yoon SH, Yun SO, Park JY, Won HY, Kim EK, Sohn HJ, Cho HI, Kim TG

Increasing importance is being given to the stimulation of Th1 response in cancer immunotherapy because its presence can shift the direction of adaptive immune responses toward protective immunity. Based on...
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Polarization of protective immunity induced by replication-incompetent adenovirus expressing glycoproteins of pseudorabies virus

Han YW, Aleyas AG, George JA, Kim SJ, Kim HK, Yoon HA, Yoo DJ, Kang SH, Kim K, Eo SK

Replication-incompetent adenoviruses expressing three major glycoproteins (gB, gC, and gD) of pseudorabies virus (PrV) were constructed and used to examine the ability of these glycoproteins to induce protective immunity against...
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NF-kB and cytokines in pancreatic acinar cells

Kim H, Seo JY, Kim KH

Reactive oxygen species (ROS), generated by infiltrating neutrophils, are considered as an important regulator in the pathogenesis and deveolpment of pancreatitis. A hallmark of the inflammatory response is the induction...
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The role of cytokines in rhinosinusitis

Min YG, Lee KS

Since the last decade, new insights into inflammatory processes have become possible by investigating the pattern of cytokines in acute and chronic sinus diseases. This review aims to update and...
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Immune mechanisms of Theiler's virus-induced demyelination

Kim BS, Palna JP

  • KMID: 755038
  • Exp Mol Med.
  • 1999 Sep;31(3):115-121.
No abstract available.
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Nuclear factor kappaB (NF-kappaB) pathway as a therapeutic target in rheumatoid arthritis

Jue DM, Jeon KI, Jeong JY

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by persistent joint swelling and progressive destruction of cartilage and bone. Current RA treatments are largely empirical in origin and their...
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