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Increased Expression of Cyclooxygenase-2 is Associated with the Progression to Cirrhosis

Jeong SW, Jang JY, Lee SH, Kim SG, Cheon YK, Kim YS, Cho YD, Kim HS, Lee JS, Jin SY, Shim CS, Kim BS

BACKGROUND/AIMS: To investigate the degree of cyclooxygenase-2 (COX-2) protein expression in chronic hepatitis and cirrhosis. METHODS: COX-2 protein expression was evaluated in 43 cases of chronic hepatitis and 24 cases...
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Guidelines of Prevention and Treatment for NSAID-related Peptic Ulcers

Lee JH, Lee YC, Jeon SW, Kim JW, Lee SW, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association of Gastroenterology

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used medications in Korea. Gastrointestinal toxicity, including peptic ulcer, is a common adverse effect of NSAIDs. Risk factors for NSAID-related peptic...
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Effects of Combination Therapy with Celecoxib and Doxycycline on Neointimal Hyperplasia and Inflammatory Biomarkers in Coronary Artery Disease Patients Treated with Bare Metal Stents

Kim WH, Ko YG, Kang KW, Kim JS, Kim BK, Choi D, Hong MK, Jang Y

PURPOSE: Cyclooxygenase (COX)-2 and matrix metalloproteinase (MMP)-9 play a key role in the pathogenesis of in-stent restenosis. We investigated the effect of a short-term therapy of celecoxib, a COX-2 inhibitor,...
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