- New COX-2 Inhibitors
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Kim D, Sung YK
- KMID: 2361428
- Korean J Med.
- 2016 Dec;91(3):250-256.
- doi: 10.3904/kjm.2016.91.3.350
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat pain and inflammation. There are two kinds of NSAID classified according to the selectivity of COX-2 inhibition: non-selective NSAIDs and cyclooxygenase... -
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- Anti-tumor mechanisms and regulation of survivin by selective cyclooxygenase-2 inhibitor
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Jang JW
- KMID: 1381460
- Korean J Hepatol.
- 2008 Sep;14(3):305-308.
- doi: 10.3350/kjhep.2008.14.3.305
No abstract available. -
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- Editor's Introduction to This Issue (G&I 15:2, 2017)
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Chung YJ
- KMID: 2384031
- Genomics Inform.
- 2017 Jun;15(2):55-55.
- doi: 10.5808/GI.2017.15.2.55
No abstract available. -
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- Renal Effects of Prostaglandins and Cyclooxygenase-2 Inhibitors
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Kim GH
- KMID: 2052304
- Electrolyte Blood Press.
- 2008 Jun;6(1):35-41.
- doi: 10.5049/EBP.2008.6.1.35
Prostaglandins (PGs) with best-defined renal functions are PGE2 and prostacyclin (PGI2). These vasodilatory PGs increase renal blood flow and glomerular filtration rate under conditions associated with decreased actual or effective... -
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- COX-2 Inhibitors in Inflammatory Bowel Disease: Friends or Foes?
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Park YS
- KMID: 937929
- Korean J Gastroenterol.
- 2007 Dec;50(6):350-355.
The cyclooxygenase (COX) is a key enzyme in the coversion of arachidonic acid to prostaglandins. COX-1 is constitutively expressed and is a critical housekeeping gene, whereas COX-2 is rapidly upregulated... -
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- Effects of Intravesical Instillation of Cyclooxygenase-2 Inhibitor on Cyclophosphamide-induced Overactive Bladder
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Jang J, Kim JC, Lee YB, Seo SI, Park YH, Hwang TK
- KMID: 2293233
- Korean J Urol.
- 2004 Dec;45(12):1241-1245.
PURPOSE: This study was performed to investigate the effects of intravesical instillation of cyclooxygenase-2 (COX-2) inhibitors on the cyclophosphamide-induced overactive bladder. MATERIALS AND METHODS: The 40 Sprague-Dawley rats were divided into... -
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- Cyclooxygenase-2 Expression in Periampullary Cancer
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Choi YJ, Jin GB, Jang LC, Park JW, Sung R, Choi JW
- KMID: 2004548
- J Korean Surg Soc.
- 2003 Jul;65(1):49-54.
PURPOSE: Cyclooxygenase-2 (COX-2) expression is up-regulated in several types of human cancers and it has been suggested that COX-2 is closely inked to carcinogenesis. The objectives of this study were... -
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- Pattern of Apoptosis by NS398, a Selective COX-2 Inhibitor, in Hepatocellular Carcinoma Cell Lines
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Park MK, Kim MK, Kim JC, Sung YK
- KMID: 2166122
- Cancer Res Treat.
- 2005 Oct;37(5):313-317.
PURPOSE: NS398, a selective COX-2 inhibitor, is known to inhibit the growth of COX-2 expressing hepatocellular carcinoma cells. The present study investigated whether the cytotoxic effect of NS398 was COX-2... -
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- Non-Steroidal Anti-Inflammatory Drug-Induced Enteropathy
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Lim YJ, Yang CH
- KMID: 2048851
- Clin Endosc.
- 2012 Jun;45(2):138-144.
- doi: 10.5946/ce.2012.45.2.138
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed drugs in the world. NSAID-induced lower gastrointestinal (GI) complications are increasing while upper GI complications are decreasing. Lower GI... -
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- Cyclooxygenase-2 inhibitors modulate skin aging in a catalytic activity-independent manner
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Lee ME, Kim SR, Lee S, Jung YJ, Choi SS, Kim WJ, Han JA
- KMID: 1389733
- Exp Mol Med.
- 2012 Sep;44(9):536-544.
It has been proposed that the pro-inflammatory catalytic activity of cyclooxygenase-2 (COX-2) plays a key role in the aging process. However, it remains unclear whether the COX-2 activity is a... -
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- Effect of Intrathecal COX Inhibitors on Inflammatory Pain and c-Fos Expression in Central Nervous System Induced by Formalin Injection in Rat
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Seo YS, Lee IO
- KMID: 2236648
- Korean J Anesthesiol.
- 2007 Jan;52(1):81-90.
- doi: 10.4097/kjae.2007.52.1.81
BACKGROUND: Prostaglandins (PGs) play important roles in the transmission of nociceptive information in the spinal cord. PGs are produced by cyclooxygenase (COX). Two forms of COX have been identified: COX-1... -
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- Roles of Serotonergic and Adrenergic Receptors in the Antinociception of Selective Cyclooxygenase-2 Inhibitor in the Rat Spinal Cord
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Jeong HJ, Lee SH, Cho SY, Lee CS, Jeong CW, Yoon MH, Kim WM
- KMID: 2074011
- Korean J Pain.
- 2011 Dec;24(4):179-184.
- doi: 10.3344/kjp.2011.24.4.179
BACKGROUND: The analgesic mechanisms of cyclooxygenase (COX)-2 inhibitors have been explained mainly on the basis of the inhibition of prostaglandin biosynthesis. However, several lines of evidence suggest that their analgesic... -
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- Cyclooxygenase-2 Expression Predicts Prognosis in Astrocytic Tumors
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Lee JM, Jung S, Rhu HH, Kim IY, Lee MC
- KMID: 1588710
- J Korean Neurosurg Soc.
- 2004 Dec;36(6):437-442.
OBJECTIVE: Cyclooxygenase-2, the inducible isoform of prostaglandin H synthesis, has been implicated in the growth and progression of a various human cancer. Although COX-2 overexpression has been observed in humangliomas,... -
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- Cyclooxygenase-2 Inhibitors and Cardivascular Risk
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Park YB
- KMID: 2168063
- Hanyang Med Rev.
- 2005 May;25(2):67-72.
Serious concerns about the cardiovascular safety of rofecoxib had been present since the VIOXX(R) Gastrointestinal Outcomes Research (VIGOR) study first suggested that the drug may increase the risk of myocardial... -
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- Effect of Selective Cyclooxygenase 2 Inhibitor in TCDD Pre-exposed Thyroid Papillary Carcinoma Cell Line
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Kim HS, Ahn KS, Lee JH, Chae YS, Won NH, Choi JS, Kim CH
- KMID: 2277513
- Korean J Pathol.
- 2011 Feb;45(1):1-8.
BACKGROUND: Cyclooxygenase 2 (COX-2) is related to carcinogenesis and progression of cancer. COX-2 has been detected in thyroid cancer. This suggests that COX-2 inhibitor may be useful to control the... -
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- The Association between Chronic Inflammation and Recurrent Cystitis in Women
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Chung H
- KMID: 2366143
- Urogenit Tract Infect.
- 2016 Dec;11(3):86-92.
- doi: 10.14777/uti.2016.11.3.86
Recurrent urinary tract infection is a common infectious disease seen in the clinic. It is very prevalent in women; as many as 15% of women develop urinary tract infection each... -
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- Effects of Selective Cyclooxygenase-2 Inhibitor NS-398 Pretreatment on the Rat Spinal Cord after Contusion Injury
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Cheong HD, Sung JK, Ham IS, Kang KS, Kim JO, Kim JW, Park TI, Sohn YK
- KMID: 2277651
- Korean J Pathol.
- 2006 Aug;40(4):255-262.
BACKGROUND: Secondary spinal cord injury (SCI) that follows an initial mechanical insult can exacerbate the overall damage, limit the restorative processes and eventually lead to an in- creased neurological deficit.... -
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- Expression of Cyclooxygenase-2 and Matrix Metalloproteinases in Sinonasal Tumor
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Do NY, Park SY, Im TS, Kim JH, Choi SJ, Kim SR, Lim SC
- KMID: 2276135
- Korean J Otolaryngol-Head Neck Surg.
- 2004 Apr;47(4):323-330.
BACKGROUND AND OBJECTIVES: The matrix metalloproteinases (MMPs) have been associated with tumor cell invasion and metastasis by mediating the degradation of extracellular matrix components. Cyclooxygenase-2 (COX-2) plays an important role... -
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- Cyclooxygenase-2 Inhibitor Reduces Hepatic Stiffness in Pediatric Chronic Liver Disease Patients Following Kasai Portoenterostomy
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Chang HK, Chang EY, Ryu S, Han SJ
- KMID: 2374120
- Yonsei Med J.
- 2016 Jul;57(4):893-899.
- doi: 10.3349/ymj.2016.57.4.893
PURPOSE: The purpose of this study was to define the role of cyclooxygenase-2 inhibitors (COX-2i) in reducing hepatic fibrosis in pediatric patients with chronic liver disease. MATERIALS AND METHODS: From September... -
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- Interleukin-1beta-Mediated MUC5AC Gene Expression and Mucin Secretion via PKC-ERK/p38-COX-2-PGE2 in Human Airway Epithelial Cells
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Kim YD, Bai CH, Woo HJ
- KMID: 2275964
- Korean J Otolaryngol-Head Neck Surg.
- 2003 Jan;46(1):27-34.
BACKGROUND AND OBJECTIVES: Mucus hypersecretion is a major problem in inflammatory airway disease. Interleukin-1beta (IL-1beta) has been implicated in the pathogenesis of inflammatory airway diseases. This study was designed to... -
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