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Aberrant Cell Cycle Regulation in Cervical Carcinoma

Kim YT, Zhao M

Carcinoma of the uterine cervix is one of the most common malignancies among women worldwide. Human papillomaviruses (HPV) have been identified as the major etiological factor in cervical carcinogenesis. However,...
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Relation between the Low Molecular Weight Cyclin E and Mutator Phenotype in Sporadic Colorectal Cancer

Park DG

  • KMID: 1940535
  • J Korean Surg Soc.
  • 2005 Sep;69(3):224-230.
PURPOSE: Cyclin E/CDK2 complexes are thought to play critical roles in multiple cell cycle events, including DNA replication, centrosome duplication, and activation of the E2F transcriptional program. Deregulation of the...
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Effect of sunitinib on the proliferation and survival of FRTL-5 cells

Kim WG, Choi HJ, Kim EY, Yim JH, Han JM, Kim JA, Kim TY, Shong YK, Kim WB

  • KMID: 1458428
  • Korean J Med.
  • 2010 Nov;79(5):509-517.
BACKGROUND/AIMS: Hypothyroidism has been reported in 36~85% of patients treated with sunitinib for renal cell carcinoma or gastrointestinal stromal tumor. However, the mechanism behind this hypothyroidism is unclear. This study...
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Pseudomonas aeruginosa Exotoxin A Reduces Chemoresistance of Oral Squamous Carcinoma Cell via Inhibition of Heat Shock Proteins 70 (HSP70)

Park SR, Lee KD, Kim UK, Gil YG, Oh KS, Park BS, Kim GC

PURPOSE: Oral squamous carcinoma (OSCC) cells exhibit resistance to chemotherapeutic agent-mediated apoptosis in the late stage of malignancy. Increased levels of heat shock proteins 70 (HSP70) in cancer cells are...
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