- Downstream molecular events in the altered profiles of lysophosphatidic acid-induced cAMP in senescent human diploid fibroblasts
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Jang IS, Rhim JH, Park SC, Yeo EJ
- KMID: 1111406
- Exp Mol Med.
- 2006 Apr;38(2):134-143.
Lysophosphatidic acid (LPA) is a phospholipid growth factor that acts through G-protein-coupled receptors. Previously, we demonstrated an altered profile of LPA-dependent cAMP content during the aging process of human diploid... -
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- Stimulatory heterotrimeric G protein augments gamma ray-induced apoptosis by up-regulation of Bak expression via CREB and AP-1 in H1299 human lung cancer cells
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Choi YJ, Kim SY, Oh JM, Juhnn YS
- KMID: 1119325
- Exp Mol Med.
- 2009 Aug;41(8):592-600.
- doi: 10.3858/emm.2009.41.8.065
Stimulatory heterotrimeric GTP-binding proteins (Gs protein) stimulate cAMP generation in response to various signals, and modulate various cellular phenomena such as proliferation and apoptosis. This study aimed to investigate the... -
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- Overexpression of Human Arginine Decarboxylase Rescues Human Mesenchymal Stem Cells against H2O2 Toxicity through Cell Survival Protein Activation
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Seo SK, Yang W, Park YM, Lee WT, Park KA, Lee JE
- KMID: 1786932
- J Korean Med Sci.
- 2013 Mar;28(3):366-373.
- doi: 10.3346/jkms.2013.28.3.366
In this study, we explored the potentiality of human arginine decarboxylase (ADC) to enhance the survival of mesenchymal stem cells (MSCs) against unfavorable milieu of host tissues as the low... -
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- Cilostazol Protects Endothelial Cells Against Lipopolysaccharide-Induced Apoptosis Through ERK1/2- and P38 MAPK-Dependent Pathways
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Lim JH, Woo JS, Shin YW
- KMID: 1717961
- Korean J Intern Med.
- 2009 Jun;24(2):113-122.
- doi: 10.3904/kjim.2009.24.2.113
BACKGROUND/AIMS: We examined the effects of cilostazol on mitogen-activated protein kinase (MAPK) activity and its relationship with cilostazol-mediated protection against apoptosis in lipopolysaccharide (LPS)-treated endothelial cells. METHODS: Human umbilical vein... -
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