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HER2 status in breast cancer: changes in guidelines and complicating factors for interpretation

Ahn S, Woo JW, Lee K, Park SY

Human epidermal growth factor receptor 2 (HER2) protein overexpression and/or HER2 gene amplification is found in about 20% of invasive breast cancers. It is a sole predictive marker for treatment...
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Clinicopathologic Implications of ALK Gene Copy Number Gain in Non-small Cell Lung Cancer

Yoo SB, Kim H, Xu X, Sun PL, Jin Y, Paik JH, Jheon S, Lee CT, Chung JH

PURPOSE: The anaplastic lymphoma kinase (ALK) gene is a potential molecular target in non-small cell lung carcinoma (NSCLC). The clinicopathologic implication of a change in the ALK gene copy number...
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