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Tracer Accumulation in Relation to Venous Thrombus on ¹⁸F-DOPA PET/CT in a Case of Persistent Hyperinsulinemic Hypoglycemia of Infancy

Arora S, Damle NA, Passah A, Sharma R, Goyal H, Arunraj ST, Gupta P, Jana M

¹⁸F-DOPA PET/CT is commonly done in patients with persistent hyperinsulinemic hypoglycemia of infancy (PHHI) to look for any focal lesion in the pancreas.We present the findings in a 20-day-old neonate...
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Images from ¹⁸F-DOPA Scan in Congenital Hyperinsulinism: Not Always a Clue for Diagnosis

Maines E, Giacomello L, D'Onofrio , Salgarello M, Gaudino R, Baggio L, Bordugo A

Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycaemia in childhood (Horm Res 70:65-72, 2008; J Clin Endocr Metab 93:869-875, 2008). ¹⁸⁻Fluoro-L-dihydroxy-phenylalanine (¹⁸F-DOPA) positron emission tomography (PET) can...
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Congenital hyperinsulinism: diagnostic and management challenges in a developing country – case report

John CM, Agarwal P, Govindarajulu S, Sundaram S, Senniappan S

Management of congenital hyperinsulinemia of infancy (CHI) is challenging. A 4-month-old female infant with persistent hypoglycemia and elevated insulin levels was diagnosed with CHI. Gallium-68 DOTANOC positron emission tomography/computed tomography...
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A novel mutation of ABCC8 gene in a patient with diazoxide-unresponsive congenital hyperinsulinism

Park JS, Lee HJ, Park CH

Congenital hyperinsulinism (CHI) is a rare condition that can cause irreversible brain damage during the neonatal period owing to the associated hypoglycemia. Hypoglycemia in CHI occurs secondary to the dysregulation...
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A Case of 2-Month-Old Infant with Persistent Hyperinsulinemic Hypoglycemia Presenting as Atonic Seizure

Kim JW, Kim DH, Kim SS

  • KMID: 1910339
  • Soonchunhyang Med Sci.
  • 2014 Jun;20(1):56-59.
Congenital hyperinsulinism is the most frequent cause of severe, persistent hypoglycemia in infancy and childhood. It is caused by an inappropriate insulin secretion from the pancreatic beta-cells secondary to various...
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Congenital hyperinsulinism: current status and future perspectives

Yorifuji T

The diagnosis and treatment of congenital hyperinsulinism (CHI) have made a remarkable progress over the past 20 years and, currently, it is relatively rare to see patients who are left...
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A Case of Persistent Hyperinsulinemic Hypoglycemia Treated with Diazoxide

Kim MS, Park EH, Kim SY, Lee DY

  • KMID: 1520749
  • J Korean Soc Pediatr Endocrinol.
  • 2007 Dec;12(2):164-167.
Congenital hyperinsulinism (CHI), the most important cause of hyperglycemia in early infancy, is a heterogenous disease characterized by dysregulation of insulin secretion. Mutations in five proteins have been associated with...
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Clinical Outcome after Pancreatectomy in Patients with Persistent Hyperinsulinemic Hypoglycemia of Infancy

Jung MH, Hwang JS, Shin CH, Yang SW, Chi JG

  • KMID: 2001523
  • J Korean Soc Pediatr Endocrinol.
  • 2000 Dec;5(2):171-181.
PURPOSE: The purpose of this study was to describe the clinical outcome after pancreatcetmy and its relationship with pathological appearances and clinical features in patients with persistent hyperinsulinemic hypoglycemia of...
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Medical Therapy in Children with Persistent Hyperinsulinemic Hypoglycemia of Infancy(PHHI)

Kim HJ, Kim MJ, Shin HS, Kim JS, Uhm MR, Ko SH, Lee SH, Jin DK

  • KMID: 2207677
  • J Korean Pediatr Soc.
  • 2000 Feb;43(2):253-259.
PURPOSE: Persistent hyperinsulinemic hypoglycemia of infancy(PHHI), which is characterised by inappropriate insulin secretion in spite of hypoglycemia, needs urgent treatment to prevent cerebral hypoglycemic damage. Although pancreatectomy is the treatment...
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Nesidioblastosis in Neonate with Persistent Hyperinsulinemic Hypoglycemia

Whang IT, Kim HS, Han HS

  • KMID: 2193882
  • J Korean Soc Pediatr Endocrinol.
  • 1998 Nov;3(2):231-236.
Nesidioblastosis, also known as persistent hyperinsulinemic hypoglycemia of infancy(PHHI) or familial hyperinsulinsm, is the most common cause of recurrent severe hypoglycemia in infancy. It is an autosomal recessive disorder characterized...
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Diffuse Nesidioblastosis of the Pancreasin Adult with Persistent Hyperinsulinemic Hypoglycemia

Lee SH, Hyoung KY, Seo GS, Shin BJ, Cho CG, Yang KS, Chae KM, Yun KJ

  • KMID: 2461629
  • J Korean Soc Endocrinol.
  • 1996 Jun;11(2):247-253.
Nesidioblastosis is a term that describes multifocal hyperplasia of all panereatic cell components and is characterized primarily by their disorganization and proliferation throughout the entire panaeas. Adult onset nesidioblastosis is...
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