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Computational Neuroscience Approach to Psychiatry: A Review on Theory-driven Approaches

Khaleghi A, Mohammadi MR, Shahi K, Nasrabadi AM

Translating progress in neuroscience into clinical benefits for patients with psychiatric disorders is challenging because it involves the brain as the most complex organ and its interaction with a complex...
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Electroconvulsive Therapy on Treatment-resistant Mania in Bipolar Disorder with No Concurrent Antipsychotics: A Case Report

Enokida T, Noda T, Usami T, Satake N, Nakagome K

Pharmacotherapy is generally the first choice for the treatment of acute mania in bipolar disorder. Electroconvulsive therapy (ECT) is reported to be an effective treatment modality for mania; however, it...
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The Moderating Effects of Accurate Expectations of Lethality in the Relationships between Suicide Intent and Medical Lethality on Suicide Attempts

Yang HJ, Jung YE, Park JH, Kim MD

Objective: The purpose of this study was to explore the accuracy of expectation of medical lethality and to identify characteristics related to high medical lethality in suicide attempters. Methods: A total...
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Psychobiotic Therapy: Method to Reinforce the Immune System

Magalhães-Guedes KT

Psychobiotics are probiotic microorganisms that beneficially affect the central nervous system functions mediated by the gut-brain axis, improving the host’s immune system. Psychobiotic microorganisms can regulate brain pathways and serotonin...
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Effect of Self-administered Transcranial Direct Stimulation in Patients with Major Depressive Disorder: A Randomized, Single-blinded Clinical Trial

Oh J, Jang KI, Jeon S, Chae JH

Objective: In numerous studies that have addressed transcranial direct current stimulation (tDCS) devices, participants visit the hospital regularly and undergo stimulation directed by health professionals. This method has the advantage...
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A Systematic Review on Cognitive Effects of Electroconvulsive Therapy in Asian Patients

Ong Y, Chan LG

Objective: Electroconvulsive therapy (ECT) is the most efficacious treatment for many major mental illnesses but is limited by cognitive side effects. However, research on the pattern and severity of ECT-related...
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The Impact of Long-acting Paliperidone in Reducing Hospitalizations and Clinical Severity in Recent Onset Schizophrenia: A Mirror-image Study in Real-world Clinical Setting

Peitl V, Margetić BA, Vidrih B, Karlović D

Objective: Schizophrenia is a debilitating disease that disrupts the lives of many affected individuals and exerts a toll on the health system. Only few studies assessed once-monthly injectable formulation of...
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Investigation of Relaxin-3 Serum Levels in terms of Social Interaction, Communication, and Appetite as a Biomarker in Children with Autism

Erden S, Nalbant K, Kılınç İ

Objective: To investigate the possible relationship between relaxin-3 and autism spectrum disorder (ASD). Methods: Serum relaxin-3 was measured in 80 children (50 children diagnosed with ASD and 30 controls). Symptom severity...
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Decline in Hospital Visits by Patients with Schizophrenia Early in the COVID-19 Outbreak in Korea

Ryu S, Nam HJ, Baek SH, Jhon M, Kim JM, Kim SW

Objective: This study investigated trends in hospital utilization by patients with schizophrenia during the first wave of the COVID-19 outbreak in Korea. Methods: The Prophet algorithm was used to predict the...
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Impact of Social Defeat Stress on DNA Methylation in Drd2, Nr3c1, and Stmn1 in Wild-type and Stmn1 Knock-out Mice

Oh YE, Nguyen TB, Rami FZ, Karamikheirabad M, Chung YC

Objective: Epigenetic profiles can be modified by stress. Dopamine receptor D2 (Drd2), glucocorticoid receptor gene (Nr3c1) and Stathmin 1 (Stmn1) genes are all implicated in adaptation to stress. The aim...
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The Korean Medication Algorithm Project for Depressive Disorder 2021: Comparisons with Other Treatment Guidelines

Woo YS, Bahk WM, Seo JS, Park YM, Kim W, Jeong JH, Shim SH, Lee JG, Jang SH, Yang CM, Wang SM, Jung MH, Sung HM, Choo IH, Yoon BH, Lee SY, Jon DI, Min KJ

The Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) first was published in 2002, and has been revised four times, in 2006, 2012, 2017, and 2021. In this review, we...
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An Experimental Study to Assess the Professional and Social Consequences of Tardive Dyskinesia

Ayyagari R, Goldschmidt D, Mu F, Caroff SN, Carroll B

Objective: Antipsychotic medications may cause tardive dyskinesia (TD), an often-irreversible movement disorder characterized by involuntary movements that are typically stereotypic, choreiform, or dystonic and may impair quality of life. This...
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Increased Serum Level of CCL5 in Children with Attention‑Deficit/ Hyperactivity Disorder: First Results about Serum Chemokines

Özaslan A, Güney E, Gülbahar Ö, Büyüktaskin D, Arslan B

Objective: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder and its aetiology is not fully understood. This study aimed to determine whether the CCL5 and CCL11 influence the ADHD...
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Comparison between Atomoxetine and OROS Methylphenidate as an Adjunctive to SSRIs in Attention-deficit/Hyperactivity Disorder Adults with Comorbid Partially Responsive Major Depressive Disorder: A Head-to-head, 12-week, Randomized, Rater-blinded Clinical Trial

Shim Sh, Woo YS, Kim JS, Heo IS, Yoon Hj, Sung HM, Lee J, Bahk WM

Objective: This study aimed to compare the efficacy and safety of atomoxetine (ATX) and OROS methylphenidate (MPH) as adjunctive to selective serotonin reuptake inhibitors (SSRIs) in adults with attention-deficit hyperactivity...
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Anxiety, Depression and Burnout Levels of Turkish Healthcare Workers at the End of the First Period of COVID-19 Pandemic in Turkey

Uz B, Savaşan E, Soğancı D

Objective: COVID-19 pandemic affected the mental health of healthcare workers (HCWs) as well as their physical health. In this study, we aimed to evaluate the anxiety, depression and burnout levels...
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Electrophysiological Changes Related to Childhood Trauma in Patients with Major Depressive Disorder: An Event-related Potential Study

Heo IS, Kwon YJ, Lee HY, Lee HS, Yoon HJ, Shim SH, Kim JS

Objective: Childhood trauma is the most important environmental factor for several psychiatric disorders. Depressed patients with childhood trauma appear to have severe symptoms that frequently recur. This study investigated whether...
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Management of Rhabdomyolysis in a Patient Treated with Clozapine: A Case Report and Clinical Recommendations

Béchard L, Corbeil O, Thivierge MA, Assaad I, Boulanger C, Mailhot MP, Turgeon-Fournier A, Roy MA, Demers MF

Clozapine has a unique efficacy in treatment-resistant schizophrenia. Its use is, however, associated with potential adverse events. Among those, clozapine induced rhabdomyolysis can compromise clozapine treatment. Recommendations surrounding the management...
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Prevalence and Comorbidities of Attention Deficit Hyperactivity Disorder Among Adults and Children/Adolescents in Korea

Seo JC, Jon DI, Shim SH, Sung HM, Woo YS, Hong J, Park S, Seo JS, Bahk WM

Objective: This study investigated the prevalence and comorbidities of attention deficit hyperactivity disorder (ADHD) among adults and children/adolescents in Korea. Methods: This study used data from the Korea Health Insurance Review...
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Long-term Safety and Efficacy of Esketamine Nasal Spray Plus an Oral Antidepressant in Patients with Treatment-resistant Depression– an Asian Sub-group Analysis from the SUSTAIN-2 Study

Jeon HJ, Ju PC, Sulaiman AH, Aziz SA, Paik JW, Tan W, Bai D, Li CT

Objective: To evaluate the long-term safety and efficacy of intranasal esketamine in patients with treatment-resistant depression from the Asian subgroup of the SUSTAIN-2 study. Methods: SUSTAIN-2 was a phase 3, open-label,...
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Prescription Patterns for Bipolar Disorder in Asian Countries: Findings from Research on Asian Prescription Pattern-Bipolar Disorder

Lin SK, Yang SY, Park SC, Jang OJ, Zhu X, Xiang YT, Ouyang WC, Javed A, Sayeed Khan MN, Grover S, Avasthi A, Kallivayalil RA, Chee KY, Chemi N, Kato TA, Hayakawa K, Pariwatcharakul P, Maramis M, Seneviratne L, Kang S, Tang WK, Oo T, Sartorius N, Tan CH, Chong MY, Park YC, Shinfuku N

Objective: Pharmacotherapy including mood stabilizers and antipsychotics are frequently used in bipolar disorder (BD); however, the lack of consensus regarding the definition of polypharmacy hinders conducting comparative studies across different...
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