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Acute Hepatitis Due to Agomelatine Use in Elderly Women with Depression: Case Series

Chang CC, Chen YJ, Chen YA, Liao YC

Although agomelatine may be associated with an increased risk of hepatotoxicity, the incidence rate of acute hepatitis seemed divergent between clinical trials and daily practice. Whether aging or gender is...
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First Manic Attack During COVID-19 Treatment: A Case Report

Varsak N, Topaloğlu M, Özdemir E

On March 11, 2020, the World Health Organization declared that the infection of novel coronavirus identified in Wuhan, China, is a pandemic. Various studies have shown that SARS-CoV-2 infection can...
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Alteration in Cngb1 Expression upon Maternal Immune Activation in a Mouse Model and Its Possible Association with Schizophrenia Susceptibility

Lee H, Kang SW, Jeong H, Kwon JT, Kim YO, Kim HJ

Objective: The cyclic nucleotide-gated channel (Cng) regulates synaptic efficacy in brain neurons by modulating Ca2+ levels in response to changes in cyclic nucleotide concentrations. This study investigated whether the expression...
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Could Irisin Levels be Affected by Physical Activity in Patients with Schizophrenia?

Erzin G, Güriz O, Yalçındağ A, Kahıloğulları A, Örsel S

Objective: The aim of this study was to explore the effect of physical activity and metabolic parameters on irisin levels in patients with schizophrenia and healthy controls. Methods: Ninety-six patients with...
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Effects of Iron Supplementation on Attention Deficit Hyperactivity Disorder in Children Treated with Methylphenidate

Tohidi S, Bidabadi E, Khosousi MJ, Amoukhteh M, Kousha M, Mashouf P, Shahraki T

Objective: To evaluate the effect of iron on the attention deficit hyperactivity disorder, treated with methylphenidate. Methods: This double-blind, randomized placebo-controlled clinical trial was performed on 50 children with attention deficit...
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Dynamic Thiol/Disulfide Homeostasis and Oxidative DNA Damage in Adult Attention Deficit Hyperactivity Disorder

Kurhan F, Alp HH

Objective: Insufficient number of oxidative stress studies have been conducted in patients with adult attention deficit hyperactivity disorder (ADHD). The objective of the current study is to examine the thiol/disulfide...
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Improved Executive Functions and Reduced Craving in Youths with Methamphetamine Addiction: Evidence from Combined Transcranial Direct Current Stimulation with Mindfulness Treatment

Alizadehgoradel J, Imani S, Nejati V, Vanderhasselt MA, Molaei B, Salehinejad MA, Ahmadi S, Taherifard M

Objective: Transcranial direct current stimulation (tDCS) and mindfulness practices have been proposed as a potential approach to improve executive functions (EFs) and reduce craving in persons with substance use disorders....
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Role of Transcranial Direct Current Stimulation in the Management of Alzheimer’s Disease: A Meta-analysis of Effects, Adherence and Adverse Effects

Saxena V, Pal A

Transcranial direct current stimulation (tDCS) is a form of novel brain stimulating method that has attracted interest owing to its relative inexpensiveness and ease of administration. It has been evaluated...
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Trazodone Add-on in COVID-19-related Selective Serotonin Reuptake Inhibitor-resistant Post-traumatic Stress Disorder in Healthcare Workers: Two Case Reports

Berardis DD, Fornaro M, Ventriglio A, Valchera A, Vellante F, Pettorruso M, Martinotti G, Fraticelli S, Giannantonio MD

COVID-19 represents a significant stress factor for all people worldwide due to several factors, including quarantine, lockdowns, fear of contagion, deaths, and other traumatic events. However, the healthcare workers (HCWs)...
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Combined Medication with Stimulants and Non-stimulants for Attention-deficit/hyperactivity Disorder

Bahn GH, Seo K

Objective: To study the efficiency and indication of combined medication with a stimulant and non-stimulant for attention-deficiency/hyperactivity disorder (ADHD), herein, the authors examined children and adult patients with ADHD. Methods: Subjects...
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Exploring Hidden Issues in the Use of Antipsychotic Polypharmacy in the Treatment of Schizophrenia

Kim JJ, Pae CU, Han C, Bahk WM, Lee SJ, Patkar AA, Masand PS

The mainstay of schizophrenia treatment is pharmacological therapy using various antipsychotics including first- and second-generation antipsychotics which have different pharmacokinetic and pharmacodynamic property leading to differential presentation of adverse events...
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Machine Learning and Deep Learning for the Pharmacogenomics of Antidepressant Treatments

Lin E, Lin CH, Lane HY

A growing body of evidence now proposes that machine learning and deep learning techniques can serve as a vital foundation for the pharmacogenomics of antidepressant treatments in patients with major...
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Relationship between Handgrip Strength and Low-grade Inflammation in Older Adults with Depression

Kang KY, Jung YE, Jang H, Kim MD, Bahk WM

Objective: The relationship among physical functional decline, low-grade inflammation, and depression remains unclear. The aim of this study was to examine the association between hand grip strength (HGS) and high-sensitivity...
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Satisfaction Survey on Antipsychotic Formulations by Schizophrenia Patients in Japan

Hatano M, Takeuchi I, Yamashita K, Morita A, Tozawa K, Sakakibara T, Hajitsu G, Hanya M, Yamada S, Iwata N, Kamei H

Objective: To identify factors affecting adherence to medication, a subjective questionnaire survey was administered to schizophrenia patients regarding the prescribed antipsychotic formulations. Methods: We evaluated the patients’ satisfaction and dissatisfaction with...
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Absence of Longer Reorientation Times in Patients Undergoing Electroconvulsive Therapy and Concomitant Treatment with Lithium

Martins-Ascencao R, Rodrigues-Silva N, Trovão N

Objective: Lithium is a drug of choice in the treatment of bipolar disorder and refractory depressive disorders. However, previous research suggests lithium has a negative cognitive impact in recovery from...
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Comparison of Quantitative Electroencephalography between Tic Disorder and Attention-Deficit/Hyperactivity Disorder in Children

Lee I, Lee J, Lim MH, Kim KM

Objective: Attention-deficit/hyperactivity disorder (ADHD) and tic disorder (TD) are among the most common comorbid psychopathologies and have a shared genetic basis. The psychopathological and neurophysiological aspects of the mechanism underlying...
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Neutrophil-lymphocyte and Platelet-lymphocyte Ratios among Adolescents with Substance Use Disorder: A Preliminary Study

Karatoprak S, Uzun N, Akıncı MA, Dönmez YE

Objective: Substance use disorder (SUD) is a serious public health problem affecting both the individual and the society, and substance use-related deaths and disability have been shown to increase gradually....
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Korean Medication Algorithm for Depressive Disorder 2021, Fourth Revision: An Executive Summary

Seo JS, Bahk WM, Woo YS, Park YM, Kim W, Jeong JH, Shim SH, Lee JG, Jang SH, Yang CM, Wang SM, Jung MH, Sung HM, Choo IH, Yoon BH, Lee SY, Jon DI, Min KJ

Objective: In the 19 years since the Korean College of Neuropsychopharmacology and the Korean Society for Affective Disorders developed the Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) in 2002,...
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Clinical Characteristics of Patients with Schizophrenia Maintained without Antipsychotics: A Cross-sectional Survey of a Case Series

Tani H, Tomita M, Suzuki T, Mimura M, Uchida H

Objective: While antipsychotics are necessary for relapse prevention in the treatment of schizophrenia in general, some minority of patients may be maintained without continuous antipsychotic treatment. However, the characteristics of...
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Decreased Cortical Thickness and Local Gyrification in Individuals with Subjective Cognitive Impairment

Youn H, Choi M, Lee S, Kim D, Suh S, Han CE, Jeong HG

Objective: Subjective cognitive impairment (SCI) is associated with future cognitive decline. This study aimed to compare cortical thickness and local gyrification index (LGI) between individuals with SCI and normal control...
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