- Recent progress in vaccine development targeting pre-clinical human toxoplasmosis
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Chu KB, Quan FS
- KMID: 2545449
- Parasit Host Dis.
- 2023 Aug;61(3):231-239.
- doi: 10.3347/PHD.22097
Toxoplasma gondii is an intracellular parasitic organism affecting all warm-blooded vertebrates. Due to the unavailability of commercialized human T. gondii vaccine, many studies have been reported investigating the protective efficacy... -
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- Differentially Expressed Gene Profile of Acanthamoeba castellanii Induced by an Endosymbiont Legionella pneumophila
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Moon EK, Park SM, Chu KB, Quan FS, Kong HH
- KMID: 2512988
- Korean J Parasitol.
- 2021 Feb;59(1):67-75.
- doi: 10.3347/kjp.2021.59.1.67
Legionella pneumophila is an opportunistic pathogen that survives and proliferates within protists such as Acanthamoeba spp. in environment. However, intracellular pathogenic endosymbiosis and its implications within Acanthamoeba spp. remain poorly... -
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- Detection of Toxoplasma gondii Infections using Virus-Like Particles Displaying T. gondii ROP4 Antigen
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Kim MJ, Mao J, Kang HJ, Chu KB, Quan FS
- KMID: 2523528
- Korean J Parasitol.
- 2021 Dec;59(6):565-572.
- doi: 10.3347/kjp.2021.59.6.565
Toxoplasma gondii ME49 infections are typically diagnosed by serological tests. However, serological diagnosis of RH strain-induced toxoplasmosis remains unknown. In order to develop seradiagnosis of above 2 kinds of infections,... -
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- Virus-Like Particles Expressing Toxoplasma gondii Rhoptry Protein 18 Induces Better Protection Than Rhoptry Protein 4 against T. gondii Infection
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Kang HJ, Lee SH, Chu KB, Lee DH, Quan FS
- KMID: 2426747
- Korean J Parasitol.
- 2018 Oct;56(5):429-435.
- doi: 10.3347/kjp.2018.56.5.429
Toxoplasma gondii is a ubiquitous protozoan parasite responsible for causing toxoplasmosis. Preventive measures for toxoplasmosis are currently lacking and as such, development of novel vaccines are of urgent need. In... -
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- Parasite Infiltration and Apoptosis in Spleen upon Toxoplasma gondii Infection
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Lee SH, Chu KB, Quan FS
- KMID: 2463744
- Korean J Parasitol.
- 2019 Oct;57(5):537-541.
- doi: 10.3347/kjp.2019.57.5.537
Toxoplasma gondii infection induces parasite infiltration and apoptosis in the spleen. However, dose-dependent parasite infiltration, apoptosis, body weight alternations and survival in mice remain largely unknown. In this study, mice... -
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- Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
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Chu KB, Kim SS, Lee SH, Lee DH, Kim AR, Quan FS
- KMID: 2360528
- Korean J Parasitol.
- 2016 Oct;54(5):637-643.
- doi: 10.3347/kjp.2016.54.5.637
The immune correlate of host resistance induced by reinfection of Trichinella spiralis remains unclear. In this study, we investigated immune correlates between the resistance and serum IgG antibody level, CD23âº... -
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- Previous Infection with Plasmodium berghei Confers Resistance to Toxoplasma gondii Infection in Mice
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Lee DH, Chu KB, Kang HJ, Lee SH, Quan FS
- KMID: 2448140
- Korean J Parasitol.
- 2019 Apr;57(2):93-99.
- doi: 10.3347/kjp.2019.57.2.93
Both Plasmodium spp. and Toxoplasma gondii are important apicomplexan parasites, which infect humans worldwide. Genetic analyses have revealed that 33% of amino acid sequences of inner membrane complex from the... -
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- The detection of Toxoplasma gondii ME49 infections in BALB/c mice using various techniques
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Kang HJ, Mao J, Kim MJ, Yoon KW, Eom GD, Chu KB, Moon EK, Quan FS
- KMID: 2548518
- Parasit Host Dis.
- 2023 Nov;61(4):418-427.
- doi: 10.3347/PHD.23048
Toxoplasma gondii infections are primarily diagnosed by serological assays, whereas molecular and fluorescence-based techniques are garnering attention for their high sensitivity in detecting these infections. Nevertheless, each detection method has... -
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- Identification of essential genes for Acanthamoeba castellanii excystation during encystation and excystation
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Kim MJ, Jo HJ, Quan FS, Chu KB, Kong HH, Moon EK
- KMID: 2561820
- Parasit Host Dis.
- 2024 Nov;62(4):399-407.
- doi: 10.3347/PHD.24062
Acanthamoeba is an opportunistic pathogen that causes Acanthamoeba keratitis, granulomatous amoebic encephalitis, and other cutaneous diseases. The life cycle of Acanthamoeba consists of 2 stages of trophozoites and cysts. Under... -
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- Virus-like particles expressing microneme-associated antigen of Plasmodium berghei confer better protection than those expressing apical membrane antigen 1
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Kim MJ, Chu KB, Yoon KW, Kang HJ, Lee DH, Moon EK, Quan FS
- KMID: 2556157
- Parasit Host Dis.
- 2024 May;62(2):193-204.
- doi: 10.3347/PHD.24017
Malaria is a global disease affecting a large portion of the world’s population. Although vaccines have recently become available, their efficacies are suboptimal. We generated virus-like particles (VLPs) that expressed... -
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- Virus-like Particle Vaccine Containing Toxoplasma gondii Rhoptry Protein 13 Induces Protection against T. gondii ME49 Infection in Mice
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Kang HJ, Chu KB, Lee SH, Kim MJ, Park H, Jin H, Quan FS
- KMID: 2463745
- Korean J Parasitol.
- 2019 Oct;57(5):543-547.
- doi: 10.3347/kjp.2019.57.5.543
Toxoplasma gondii can infect humans worldwide, causing serious diseases in pregnant women and immunocompromised individuals. T. gondii rhoptry protein 13 (ROP13) is known as one of the key proteins involved... -
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