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Ultrasound-guided transient elastography and two-dimensional shear wave elastography for assessment of liver fibrosis: emphasis on technical success and reliable measurements

Lee J, Kang HJ, Yoon JH, Lee JM

Purpose: This study investigated whether the use of ultrasound (US) guidance in transient elastography (TE) improved the technical success and reliability of liver stiffness (LS) measurements and whether 2-dimensional (2D)...
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Child-Pugh B or C Cirrhosis Increases the Risk for Bleeding Following Colonoscopic Polypectomy

Soh H, Chun Jy, Hong SW, Park Sn, Lee YB, Lee HJ, Cho EJ, Lee JH, Yu SJ, Im JP, Kim YJ, Kim JS, Yoon JH

Background/Aims: The risk for colonoscopic postpolypec-tomy bleeding (PPB) in patients with chronic liver disease (CLD) remains unclear. We determined the incidence and risk factors for colonoscopic PPB in patients with...
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A Prospective Blinded Study of Endoscopic Ultrasound Elastography in Liver Disease: Towards a Virtual Biopsy

Schulman A, Lin MV, Rutherford A, Chan WW, Ryou M

BACKGROUND/AIMS: Liver biopsy has traditionally been used for determining the degree of fibrosis, however there are several limitations. Endoscopic ultrasound (EUS) real-time elastography (RTE) is a novel technology that uses...
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The Pallidal Index in Patients with Acute-on-Chronic Liver Disease: Is It a Predictor of Severe Hepatic Encephalopathy?

Lee DH, Lee HJ, Hahm MH

PURPOSE: To evaluate the clinical significance of T1 high signal intensity on the globus pallidus as a predictor of severe hepatic encephalopathy in patients with acute-on-chronic liver failure (ACLF), which...
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Acute-on-Chronic Liver Failure

Kim DJ

Acute-on-chronic liver failure (ACLF) is increasingly recognized as a distinct disease entity associated with acute deterioration of liver function in patients with chronic liver disease. Although no widely accepted diagnostic...
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Growth Differentiation Factor 15 Predicts Chronic Liver Disease Severity

Lee ES, Kim SH, Kim HJ, Kim KH, Lee BS, Ku BJ

BACKGROUND/AIMS: Growth differentiation factor 15 (GDF-15) belongs to the transforming growth factor-β superfamily. GDF-15 is emerging as a biomarker for several diseases. The aim of this study was to determine...
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Decreased S100B expression in chronic liver diseases

Baik SJ, Kim TH, Yoo K, Moon IH, Choi JY, Chung KW, Song DE

BACKGROUND/AIMS: Hepatic innervation in liver diseases is not fully understood. We here evaluated S100B expression as a marker of hepatic nerves in patients with various chronic liver diseases, topographically and...
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Hemorheological Alteration in Patients Clinically Diagnosed with Chronic Liver Diseases

Jang B, Han JW, Sung PS, Jang JW, Bae SH, Choi JY, Cho YI, Yoon SK

Since liver function is changed by chronic liver diseases, chronic liver disease can lead to different hemorheological alterations during the course of the progression. This study aims to compare alterations...
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Therapeutic Effects of Mesenchymal Stem Cells for Patients with Chronic Liver Diseases: Systematic Review and Meta-analysis

Kim G, Eom YW, Baik SK, Shin Y, Lim YL, Kim MY, Kwon SO, Chang SJ

Based on their ability to differentiate into multiple cell types including hepatocytes, the transplantation of mesenchymal stem cells (MSCs) has been suggested as an effective therapy for chronic liver diseases....
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Relationship of Liver Stiffness and Controlled Attenuation Parameter Measured by Transient Elastography with Diabetes Mellitus in Patients with Chronic Liver Disease

Ahn JM, Paik YH, Kim SH, Lee JH, Cho JY, Sohn W, Gwak GY, Choi MS, Lee JH, Koh KC, Paik SW, Yoo BC

High prevalence of diabetes mellitus in patients with liver cirrhosis has been reported in many studies. The aim of our study was to evaluate the relationship of hepatic fibrosis and...
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The PERFECT Study (PEnnel Real liFe Efficacy Clinical Trial), a Double-Blind, Randomized, Multicenter Trial Examining the Efficacy of Biphenyl Dimethyl Dicarboxylate Combined with Garlic Oil in Patients with Transaminase Elevated Chronic Liver Disease

Kim HJ, Lee JS, Lee HW, Kim MY, Nam SW, Sohn JH, Cho SH, Yoon SG, Yang JM, Park CK, Rim GS, Lee YS

  • KMID: 2268491
  • Korean J Med.
  • 2014 Feb;86(2):179-189.
BACKGROUND/AIMS: Biphenyl dimethyl dicarboxylate (DDB) combined with garlic oil (pennel) has been used to treat chronic liver disease. A randomized, double-blind, active- and placebo-controlled clinical trial was conducted to investigate...
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The Effect of Gd-EOB-DPTA on the Stiffness Value of Magnetic Resonance Elastography in Evaluating Hepatic Fibrosis

Lee JE, Lee JM, Lee YJ, Yoon JH, Lee KB, Han JK, Choi BI

PURPOSE: To evaluate the effect of gadoxetic acid on the measurement of the stiffness value of MR elastography (MRE) used to evaluate hepatic fibrosis (HF). MATERIALS AND METHODS: MRE was obtained...
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Clinical applications of transient elastography

Jung KS, Kim SU

Chronic liver disease represents a major public health problem, accounting for significant morbidity and mortality worldwide. As prognosis and management depend mainly on the amount and progression of liver fibrosis,...
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Ischemia-Modified Albumin Levels in Children with Chronic Liver Disease

Cakir M, Karahan SC, Mentese A, Sag E, Cobanoglu , Polat TB, Erduran E

  • KMID: 2167369
  • Gut Liver.
  • 2012 Jan;6(1):92-97.
BACKGROUND/AIMS: Ischemia-modified albumin (IMA) levels have been shown to correlate with the severity of liver failure in adults. However, the role of IMA levels has not been evaluated in children...
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A study of the awareness of chronic liver diseases among Korean adults

Jun DW, Cho YK, Sohn JH, Lee CH, Kim SH, Eun JR

BACKGROUND/AIMS: Chronic liver disease is closely associated with lifestyle, and public enlightenment of the lifestyle factors is important in reducing prevalence of chronic liver disease. The KASL (Korean Association for...
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Clinical factors influencing liver stiffness as measured by transient elastography (Fibroscan(R)) in patients with chronic liver disease

Bae RC, Cho HJ, Oh JT, Lee EK, Heo J, Shin KY, Park SY, Jeong MK, Jeon SW, Cho CM, Tak WY, Kweon YO

BACKGROUND/AIMS: Transient elastography as performed using the Fibroscan(R) is a useful noninvasive method for evaluating hepatic fibrosis. However, recent studies have found that liver stiffness measurement (LSM) values are inappropriately...
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Usefulness of Non-invasive Markers for Predicting Significant Fibrosis in Patients with Chronic Liver Disease

Lee HH, Seo YS, Um SH, Won NH, Yoo H, Jung ES, Kwon YD, Park S, Keum B, Kim YS, Yim HJ, Jeen YT, Chun HJ, Kim CD, Ryu HS

The purpose of this prospective study was to verify and compare the strengths of various blood markers and fibrosis models in predicting significant liver fibrosis. One hundred fifty-eight patients with...
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The value of serum retinol-binding protein 4 levels for determining disease severity in patients with chronic liver disease

Kwon JH, Park ST, Kim GD, You CR, Kim JD, Woo HY, Jang JW, Kim CW, Bae SH, Choi JY, Yoon SK

BACKGROUNDS/AIMS: Serum retinol-binding protein 4 (RBP4) is known to be a specific transport protein for retinol, and has recently been reported to be associated with insulin resistance. Hyaluronic acid (HA)...
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Clinical impact of nonalcoholic fatty liver disease on other medical diseases

Yun JW, Cho YK

  • KMID: 2257382
  • Korean J Med.
  • 2009 Jan;76(1):25-29.
Non alcoholic fatty liver disease (NAFLD) has been recognized as a hepatic manifestation of systemic metabolic disease associated with insulin resistance. Recent studies have reported that NAFLD is related with...
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Current Status and Clinical Course of Hepatitis C Virus in Korea

Kwon JH, Bae SH

  • KMID: 1767540
  • Korean J Gastroenterol.
  • 2008 Jun;51(6):360-367.
The mortality due to chronic liver disease, including liver cirrhosis and hepatocellular carcinoma (HCC), ranks as one of the highest in Korea. The prevalence rates of hepatitis C virus (HCV)...
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