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Adefovir-induced Fanconi syndrome associated with osteomalacia

Park S, Kim WI, Cho DH, Kim YJ, Kim HS, Kim JH, Cha SK, Park KS, Lee JH, Lee SM, Lee EY

Fanconi syndrome is a dysfunction of the proximal renal tubules that results in impaired reabsorption and increased urinary loss of phosphate and other solutes. The pathophysiology of drug-induced Fanconi syndrome...
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Expression of Fibroblast Growth Factor 21 and β-Klotho Regulates Hepatic Fibrosis through the Nuclear Factor-κB and c-Jun N-Terminal Kinase Pathways

Lee KJ, Jang YO, Cha SK, Kim MY, Park KS, Eom YW, Baik SK

BACKGROUND/AIMS: Fibroblast growth factor (FGF) 21 is associated with hepatic inflammation and fibrosis. However, little is known regarding the effects of inflammation and fibrosis on the β-Klotho and FGF21 pathway...
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Serum Fibroblast Growth Factor 21 and New-Onset Metabolic Syndrome: KoGES-ARIRANG Study

Choi JR, Kim JY, Park IH, Huh JH, Kim KW, Cha SK, Park KS, Sohn JH, Park JT, Koh SB

PURPOSE: Fibroblast growth factor 21 (FGF21) is a crucial metabolic regulator, with multiple favorable effects on glucose homeostasis and lipid metabolism. Since serum FGF21 level has been implicated as a...
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Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes

Ly LD, Xu S, Choi SK, Ha CM, Thoudam T, Cha SK, Wiederkehr A, Wollheim C, Lee IK, Park KS

Free fatty acids (FFAs) are important substrates for mitochondrial oxidative metabolism and ATP synthesis but also cause serious stress to various tissues, contributing to the development of metabolic diseases. CD36...
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Influencing Factors on Cardio-cerebrovascular Disease Risk Factors in Young Men: Focusing on Obesity Indices

Kim CG, Lee SH, Cha SK

PURPOSE: The purpose of this study was to investigate influences of drinking, smoking, and obesity indices on cardio-cerebrovascular disease risk factors in Korean young men. METHODS: The subjects were 234 young...
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Orai1 Expression Is Closely Related with Favorable Prognostic Factors in Clear Cell Renal Cell Carcinoma

Lkhagvadorj S, Kim JH, Oh SS, Lee MR, Jung JH, Chung HC, Cha SK, Eom M

Store-operated calcium (Ca2+) entry (SOCE) is the principal Ca2+ entry route in non-excitable cells, including cancer cells. We previously demonstrated that Orai1 and STIM1, the molecular components of SOCE, are...
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Klotho plays a critical role in clear cell renal cell carcinoma progression and clinical outcome

Kim JH, Hwang KH, Lkhagvadorj S, Jung JH, Chung HC, Park KS, Kong ID, Eom M, Cha SK

Klotho functions as a tumor suppressor predominantly expressed in renal tubular cells, the origin of clear cell renal cell carcinoma (ccRCC). Altered expression and/or activity of growth factor receptor have...
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Comparison of Stress, Depression and Suicidal Ideation between Nursing Students and Students of Other Majors

Cha SK, Lee EM

PURPOSE: This study compares differences in stress, depression and suicidal ideation between nursing and students of other academic disciplines. METHODS: Nursing students (n=105) and students of other majors (n=148) were surveyed...
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Effects of Clozapine, Haloperidol, and Fluoxetine on the Reversal of Cocaine-Induced Locomotor Sensitization

Cha SK, Kang UG

OBJECTIVE: Repeated treatment with psychostimulants induces sensitization of the dopaminergic system in the brain. Dopaminergic sensitization has been proposed as a mechanism of psychosis. Although antipsychotics block the expression of...
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Insulin Receptor Expression in Clear Cell Renal Cell Carcinoma and Its Relation to Prognosis

Lkhagvadorj S, Oh SS, Lee MR, Jung JH, Chung HC, Cha SK, Eom M

PURPOSE: Both insulin and insulin-like growth factor (IGF)-1 signaling are key regulators of energy metabolism, cellular growth, proliferation, and survival. The IGF-1 receptor (IGF-1R) is overexpressed in most types of...
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Influence of Emotional Awareness, Ambivalence over Emotional Expressiveness and Emotional Regulation Style on Nursing Student Adjustment

Park S, Kim CG, Cha SK

  • KMID: 2327509
  • J Korean Acad Soc Nurs Educ.
  • 2014 May;20(2):300-311.
PURPOSE: This study was conducted to identify influence of emotional awareness, ambivalence over emotional expressiveness and emotional regulation style on nursing student adjustment. METHOD: One hundred and sixty nine nursing students...
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Effects of Combined Treatments of Lithium and Valproate on the Phosphorylation of ERK1/2 and Transcriptional Activity of ELK1 and C-FOS in PC12 Cells

Cha SK, Kim SH, Ha K, Shin SY, Kang UG

  • KMID: 2299849
  • Korean J Biol Psychiatry.
  • 2013 Nov;20(4):159-165.
OBJECTIVES: Mechanisms of clinical synergistic effects, induced by co-treatments of lithium and valproate, are unclear. Extracellular signal-regulated kinase (ERK) has been suggested to play important roles in mechanisms of the...
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Risk Factors for Pediatric Inpatient Falls

Cho MS, Song MR, Cha SK

PURPOSE: The purpose of this study was to identify risk factors for pediatric inpatients falls. METHODS: The study was a matched case-control design. The participants were 279 patients under the age...
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Development and Effectiveness of the Job Stress Management Program for Health Care Professionals

Han KS, Choi MY, Lee EM, Lim HS, Park YH, Yang YK, Cha SK

  • KMID: 2322660
  • J Korean Acad Psychiatr Ment Health Nurs.
  • 2013 Sep;22(3):180-192.
PURPOSE: The purpose of this study was to evaluate the effects of the Job Stress Management Program (JSMP) combined with communication skills training for health care professionals. METHODS: The study design...
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Clinical Nurses' Knowledge and Visual Differentiation Ability in Pressure Ulcer Classification System and Incontinence-associated Dermatitis

Lee YJ, Park S, Kim JY, Kim CG, Cha SK

PURPOSE: This study was done to compare clinical nurses' knowledge and visual differentiation diagnostic ability for the pressure ulcer classification system (PUCS) and incontinence-associated dermatitis (IAD). METHODS: A convenience sample of...
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Development of a Program to Facilitate Evidence-Based Practice Based on the Transtheoretical Model

Cho MS, Cho YA, Song MR, Kim MK, Cha SK

  • KMID: 2298266
  • Korean J Adult Nurs.
  • 2013 Apr;25(2):136-147.
PURPOSE: This study developed a program to facilitate evidence-based practice (EBP) in one nursing organization, and identifies the effects of the program on the nurses' EBP facilitators. METHODS: The program was...
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Comparison of success rates of orthodontic mini-screws by the insertion method

Kim JS, Choi SH, Cha SK, Kim JH, Lee HJ, Yeom SS, Hwang CJ

OBJECTIVE: The aim of this study was to compare the success rates of the manual and motor-driven mini-screw insertion methods according to age, gender, length of mini-screws, and insertion sites. METHODS:...
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Nurses' Perceptions regarding Evidence-Based Practice Facilitators in a Tertiary Hospital

Cho MS, Song MR, Cha SK

  • KMID: 2295656
  • J Korean Acad Fundam Nurs.
  • 2011 Aug;18(3):300-309.
PURPOSE: The purpose of this study was to investigate facilitators of evidence-based practice (EBP) in Clinical Nurses. METHOD: The instruments used in study were the EBP facilitator scale developed by Nagy...
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Effects of various combinations of cryoprotectants and cooling speed on the survival and further development of mouse oocytes after vitrification

Cha SK, Kim BY, Kim MK, Kim YS, Lee WS, Yoon TK, Lee DR

OBJECTIVE: The objectives of this study were to analyze efficacy of immature and mature mouse oocytes after vitrification and warming by applying various combinations of cryoprotectants (CPAs) and/or super-rapid cooling...
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WNKs: protein kinases with a unique kinase domain

Huang CL, Cha SK, Wang HR, Xie J, Cobb MH

  • KMID: 1090959
  • Exp Mol Med.
  • 2007 Oct;39(5):565-573.
WNKs (with-no-lysine [K]) are a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine relative to all other protein kinases. The roles of WNK kinases in...
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