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Comments on: a phase 1/2a, dose-escalation, safety and preliminary efficacy study of oral therapeutic vaccine in subjects with cervical intraepithelial neoplasia 3

Zhang N, Wang H, Yang J

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A phase 1/2a, dose-escalation, safety and preliminary efficacy study of oral therapeutic vaccine in subjects with cervical intraepithelial neoplasia 3

Park YC, Ouh YT, Sung MH, Park HG, Kim TJ, Cho CH, Park JS, Lee JK

OBJECTIVE: Persistent infection of HPV increases the chance of carcinoma in situ of cervix through stages of cervical intraepithelial neoplasia (CIN) 1, 2, and 3, and finally progresses into cervical...
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Incidence and costs of cervical intraepithelial neoplasia in the Korean population

Chang HK, Seo SS, Myong JP, Yu YL, Byun SW

OBJECTIVE: The purpose of this study was to assess the incidence rate of cervical intraepithelial neoplasia (CIN) and cervical cancer, and their costs according to age. METHODS: We collected data on...
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Risks of cervical intraepithelial neoplasia grade 3 or invasive cancers in ASCUS women with different management: a population-based cohort study

Tai YJ, Chen YY, Hsu HC, Chiang CJ, You SL, Chen CA, Cheng WF, Taiwan Cervical Cancer Control Task Force

OBJECTIVE: To investigate the progression risk of atypical squamous cells of undetermined significance (ASCUS) with different clinical managements. METHODS: Women with their first diagnosis of ASCUS cytology were retrieved from the...
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Programmed death-1 (PD-1) expression in cervical intraepithelial neoplasia and its relationship with recurrence after conization

Chang H, Hong JH, Lee JK, Cho HW, Ouh YT, Min KJ, So KA

OBJECTIVE: Impaired local cellular immunity contributes to persistent human papillomavirus (HPV) infection and development of cervical intraepithelial neoplasia (CIN). Programmed death-1 (PD-1) and its ligands PD-ligand-1 (L1) and PD-L2 are...
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Efficacy of loop electrosurgical excision procedure with cold coagulation for treating cervical intraepithelial neoplasia: A two center cohort study

Kim HS, Kwon JE, Kim JH, Kim A, Lee NR, Kim M, Lee M, Suh DH, Kim YB

OBJECTIVE: To evaluate the efficacy of loop electrosurgical excision procedure (LEEP) combined with cold coagulation for treating cervical intraepithelial neoplasia (CIN). METHODS: We reviewed clinic-pathologic data of 498 patients treated with...
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Type-specific persistence or regression of human papillomavirus genotypes in women with cervical intraepithelial neoplasia 1: A prospective cohort study

Cho HW, So KA, Lee JK, Hong JH

OBJECTIVE: To evaluate the type-specific human papillomavirus (HPV) persistence or regression in women with or less than low-grade cervical intraepithelial neoplasia (CIN). METHODS: This prospective cohort study included patients with or...
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Effect of human papillomavirus genotype on severity and prognosis of cervical intraepithelial neoplasia

Ku CH, Lee SH, Lee SP

  • KMID: 2313980
  • Obstet Gynecol Sci.
  • 2014 Jan;57(1):37-43.
OBJECTIVE: This study evaluated the effect of the specific human papillomavirus (HPV) genotypes on severity and prognosis in cervical intraepithelial neoplasia (CIN) patients. METHODS: The medical records of 446 patients treated...
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Expression of claudin-1, claudin-4 and zonula occludens-1 in cervical intraepithelial neoplasia and invasive squamous cell carcinoma

Lee SK, Rho HK, Park TY, Kang KH, Cho TI, Lee TJ

  • KMID: 2077793
  • Korean J Obstet Gynecol.
  • 2007 Oct;50(10):1378-1385.
OBJECTIVE: Cell to cell and cell to extracellular matrix interaction are crucial in tumor development and progression. Tight junction proteins such as claudins and zonula occludens-1 (ZO-1) play an important...
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The expression of Ki-67, p63, p53, and p27 as a biological marker for grading cervical intraepithelial neoplasia and cervical carcinoma

Kim YJ, Lee HJ, Kim SH, Park MH, Cho SH

  • KMID: 2273115
  • Korean J Obstet Gynecol.
  • 2007 Apr;50(4):629-637.
OBJECTIVE: To determine the pattern of expression of p63, p27, and p53 as well as Ki-67 and its efficacy to discriminate the cervical lesion such as intraepithelial lesion, microinvasive carcinoma,...
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Comparison of human papillomavirus DNA polymerase chain reaction with cervical cytology as a screening test for the detection of cervical intraepithelial neoplasia

Jeon SR, Cho HY, Jung HJ, Choi EK

  • KMID: 2143511
  • Korean J Gynecol Oncol.
  • 2006 Dec;17(4):272-278.
OBJECTIVE: To evaluate the result of the human papillomavirus (HPV) DNA polymerase chain reaction (PCR) in comparison with cervical cytology for the detection of cervical intraepithelial neoplasia (CIN) and invasive...
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Clinical Efficacy of Human Papillomavirus DNA test after Loop Electrosurgical Excision Procedure in Cervical Intraepithelial Neoplasia

Kim YR, Lee JH, Yang YJ, Rho KO, Oh BC

  • KMID: 2272899
  • Korean J Obstet Gynecol.
  • 2006 Oct;49(10):2148-2155.
OBJECTIVE: The aim of this study was to analyze a relation between the recurrence of cervical intraepithelial neoplasia (CIN) and the detection of high-risk human papillomavirus (HPV) DNA after loop...
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Efficacy of loop conization with right-angled triangular shaped excisor in patients with cervical intraepithelial neoplasia 3

Choi IJ, Kwak BG, Cha MS

  • KMID: 2083892
  • Korean J Gynecol Oncol.
  • 2006 Sep;17(3):222-226.
OBJECTIVE: To evaluate the therapeutic value of conization using right-angled triangular shape loop cone biopsy excisor in patients with CIN 3 who want preserve the uterus. METHODS: A retrospective review of...
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The association of the cervical intraepithelial neoplasia and human papillomavirus viral load

Park JS, Ryu HS, Chang SJ, Kim YM, Chang KH, Lee JP

  • KMID: 2077523
  • Korean J Obstet Gynecol.
  • 2005 Dec;48(12):2888-2895.
OBJECTIVE: The purpose of this study was to determine the relationship between the cervical intraepithelial neoplasia (CIN) and human papillomavirus (HPV) DNA load and to evaluate the efficacy of viral...
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Follow-up of Cervical Intraepithelial Neoplasia after Conization: The Clinical Usefulness of Repeat Conization

Shin BS, Lee DH, Kim KH, Yoon MS, Choi OH

  • KMID: 2272731
  • Korean J Obstet Gynecol.
  • 2005 Nov;48(11):2586-2593.
OBJECTIVE: This study is aimed to analyze the results of follow up after conization and to determine the value of repeat conization for treatment of cervical intraepithelial neoplasia (CIN) III. METHODS:...
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The change of trend on surgical treatment of patients with cervical intraepithelial neoplasia 3 in Incheon and Bucheon area

Song ES

  • KMID: 2272702
  • Korean J Obstet Gynecol.
  • 2005 Oct;48(10):2330-2335.
OBJECTIVE: To know the ratio of hysterectomies and cones for the treatment of CIN 3 in Incheon and Bucheon area, and to know the trend of changes of treatments according...
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Selenium, Manganese, Copper and Zinc Contents in Serum of Patients with Cervical Intraepithelial Neoplasia

Bae HS, Lee GJ, Ahn HS

  • KMID: 2233473
  • Korean J Community Nutr.
  • 2005 Oct;10(5):700-707.
The purpose of this study was to investigate the implications of dietary intake and the level of serum micronutrients (Se, Mn, Cu, Zn), lipid peroxidation, and antioxidant capacity in Korean...
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Antioxidant Vitamins Intake and Antioxidant System in Exfoliated Cervicovaginal Cells of the Patient with Cervical Intraepithelial Neoplasia

Chung HW, Kim TJ, Lee KH, Lee GJ, Ahn HS

  • KMID: 2272476
  • Korean J Obstet Gynecol.
  • 2004 Dec;47(12):2415-2423.
OBJECTIVE: The purpose of this study was to investigate the dietary intake of antioxidant vitamins, the level of antioxidant vitamins (retinol, beta-carotene, alpha-tocopherol), lipid peroxidation, and the capacity of antioxidants...
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The Pattern of Fhit and p53 Expression in Cervical Intraepithelial Neoplasm and Invasive Cervical Cancer

Joo SH, Myong NH, Park JW

  • KMID: 2272474
  • Korean J Obstet Gynecol.
  • 2004 Dec;47(12):2403-2048.
OBJECTIVE: To evaluate Fragile histidine triad (Fhit) and p53 expression pattern in cervical intraepithelial neoplasm (CIN) and invasive cervical cancer, and to verify the correlation between the loss of Fhit...
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Clinical Usefulness of Cervicogram as Primary Screening Test of Cervical Intraepithelial Neoplasia

Kim YR, Kim YT, Kim SH, Kim JW, Yoon BS, Chung DJ

  • KMID: 2272363
  • Korean J Obstet Gynecol.
  • 2004 Jun;47(6):1113-1119.
OBJECTIVE: The aim of this study is to evaluate the clinical usefulness of cervicogram as primary screening test of cervical intraepithelial neoplasia. METHODS: Total 294 women who had undergone cervicogram and...
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