- Senescent tumor cells in colorectal cancer are characterized by elevated enzymatic activity of complexes 1 and 2 in oxidative phosphorylation
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Shin JS, Kim TG, Kim YH, Eom SY, Park SH, Lee DH, Park TJ, Park SS, Kim JH
- KMID: 2547928
- J Pathol Transl Med.
- 2023 Nov;57(6):305-314.
- doi: 10.4132/jptm.2023.10.09
Background: Cellular senescence is defined as an irreversible cell cycle arrest caused by various internal and external insults. While the metabolic dysfunction of senescent cells in normal tissue is relatively... -
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- Cyclin-Dependent Kinase Inhibitor 2A is a Key Regulator of Cell Cycle Arrest and Senescence in Endothelial Colony-Forming Cells in Moyamoya Disease
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Choi SA, Moon YJ, Koh EJ, Phi JH, Lee JY, Kim KH, Kim SK
- KMID: 2547458
- J Korean Neurosurg Soc.
- 2023 Nov;66(6):642-651.
- doi: 10.3340/jkns.2023.0005
Objective : Endothelial colony-forming cells (ECFCs) have been reported to play an important role in the pathogenesis of moyamoya disease (MMD). We have previously observed stagnant growth in MMD ECFCs... -
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- Expression of Senescence-Associated Secretory Phenotype in Senescent Gingival Fibroblasts
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Lee S
- KMID: 2544470
- J Dent Hyg Sci.
- 2023 Jun;23(2):169-175.
- doi: 10.17135/jdhs.2023.23.2.169
Background: Although microbial infection is direct cause of periodontal disease, various environmental factors influence the disease severity. Aging is considered a risk factor for oral diseases, with the prevalence of... -
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- Skeletal Senescence with Aging and Type 2 Diabetes
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Farr JN
- KMID: 2543315
- Endocrinol Metab.
- 2023 Jun;38(3):295-301.
- doi: 10.3803/EnM.2023.1727
Osteoporosis and type 2 diabetes (T2D) are common diseases that often coexist. While both of these diseases are associated with poor bone quality and increased fracture risk, their pathogenesis of... -
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- Lyso-globotriaosylsphingosine induces endothelial dysfunction via autophagy-dependent regulation of necroptosis
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Hwang AR, Park S, Woo CH
- KMID: 2541635
- Korean J Physiol Pharmacol.
- 2023 May;27(3):231-240.
- doi: 10.4196/kjpp.2023.27.3.231
Fabry disease is a lysosomal storage disorder characterized by the lysosomal accumulations of glycosphingolipids in a variety of cytotypes, which include endothelial cells. The disease is inherited and originates from... -
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- Inhibition of miR-146a-5p and miR-8114 in Insulin-Secreting Cells Contributes to the Protection of Melatonin against Stearic Acid-Induced Cellular Senescence by Targeting Mafa
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Su S, Zhao Q, Dan L, Lin Y, Li X, Zhang Y, Yang C, Dong Y, Li X, Regazzi R, Sun C, Chu X, Lu H
- KMID: 2537291
- Endocrinol Metab.
- 2022 Dec;37(6):901-917.
- doi: 10.3803/EnM.2022.1565
Background: Chronic exposure to elevated levels of saturated fatty acids results in pancreatic β-cell senescence. However, targets and effective agents for preventing stearic acid-induced β-cell senescence are still lacking. Although... -
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- Autophagy May Mediate Cellular Senescence by Nicotine Stimulation in Gingival Fibroblasts
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Jun NR, Jang JH, Lee JY, Lee SI
- KMID: 2533373
- J Dent Hyg Sci.
- 2022 Sep;22(3):164-170.
- doi: 10.17135/jdhs.2022.22.3.164
Background: When cells are damaged by nicotine, cellular senescence due to oxidative stress accelerates. In addition, stress-induced inflammatory response and cellular senescence cause the accumulation of damaged organelles in cells,... -
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- The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis
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Go S, Kang M, Kwon SP, Jung M, Jeon OH, Kim BS
- KMID: 2520642
- Tissue Eng Regen Med.
- 2021 Oct;18(5):841-850.
- doi: 10.1007/s13770-021-00346-z
BACKGROUND Ferroptosis is an iron-dependent, non-apoptotic programmed cell death. Cellular senescence contributes to aging and various age-related diseases through the expression of a senescence-associated secretory phenotype (SASP). Senescent cells are often... -
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- Luteolin inhibits H2O2 -induced cellular senescence via modulation of SIRT1 and p53
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Zhu RZ, Li BS, Gao SS, Seo JH, Choi BM
- KMID: 2516869
- Korean J Physiol Pharmacol.
- 2021 Jul;25(4):297-305.
- doi: 10.4196/kjpp.2021.25.4.297
Luteolin, a sort of flavonoid, has been reported to be involved in neuroprotective function via suppression of neuroinflammation. In this study, we investigated the protective effect of luteolin against oxidative... -
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- Pathogenesis and prevention of skin aging
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Cho S
- KMID: 2516796
- J Korean Med Assoc.
- 2021 Jun;64(6):438-446.
- doi: 10.5124/jkma.2021.64.6.438
Background: As global life expectancy increases, an interest in maintaining health and beauty in old age has increased. As a barrier organ, the skin is an ideal model for studying... -
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- Late Passage Cultivation Induces Aged Astrocyte Phenotypes in Rat Primary Cultured Cells
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Bang M, Gonzales EL, Shin CY, Kwon KJ
- KMID: 2513482
- Biomol Ther.
- 2021 Mar;29(2):144-153.
- doi: 10.4062/biomolther.2020.175
Astrocytes play various important roles such as maintaining brain homeostasis, supporting neurons, and secreting inflammatory mediators to protect the brain cells. In aged subjects, astrocytes show diversely changed phenotypes and... -
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- Cellular Senescence in Pterygium
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Kim JH, Lee SJ, Lee KW, Kim JC
- KMID: 2505304
- J Korean Ophthalmol Soc.
- 2020 Aug;61(8):861-867.
- doi: 10.3341/jkos.2020.61.8.861
Purpose: To determine cellular senescence in pterygium by studying the expression of senescence-related markers. Methods: Impression cytology was performed on 28 eyes of 28 patients diagnosed with pterygium or pinguecula from... -
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- Cellular Senescence in Arterial Diseases
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Shimizu I, Minamino T
- KMID: 2470802
- J Lipid Atheroscler.
- 2020 Jan;9(1):79-91.
- doi: 10.12997/jla.2020.9.1.79
Cell-proliferation potency is limited, as cells cannot proceed through the cell cycle continually. Instead, they eventually show an irreversible arrest of proliferation, commonly referred to as cellular senescence. Following the... -
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- Etoposide Induces Mitochondrial Dysfunction and Cellular Senescence in Primary Cultured Rat Astrocytes
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Bang M, Kim DG, Gonzales E, Kwon KJ, Shin CY
- KMID: 2462880
- Biomol Ther.
- 2019 Nov;27(6):530-539.
- doi: 10.4062/biomolther.2019.151
Brain aging is an inevitable process characterized by structural and functional changes and is a major risk factor for neurodegenerative diseases. Most brain aging studies are focused on neurons and... -
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- Angiotensin II Type 1 Receptor Blocker, Fimasartan, Reduces Vascular Smooth Muscle Cell Senescence by Inhibiting the CYR61 Signaling Pathway
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Kim I, Park CS, Lee HY
- KMID: 2450393
- Korean Circ J.
- 2019 Jul;49(7):615-626.
- doi: 10.4070/kcj.2018.0379
BACKGROUND AND OBJECTIVES: Angiotensin II (Ang II) has been suggested to accelerate vascular senescence, however the molecular mechanism(s) remain unknown. METHODS: We cultured human coronary artery smooth muscle cells (hCSMCs) and... -
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- Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes
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Bang M, Ryu O, Kim DG, Mabunga DF, Cho KS, Kim Y, Han SH, Kwon KJ, Shin CY
- KMID: 2447855
- Biomol Ther.
- 2019 May;27(3):283-289.
- doi: 10.4062/biomolther.2018.107
Brain aging induces neuropsychological changes, such as decreased memory capacity, language ability, and attention; and is also associated with neurodegenerative diseases. However, most of the studies on brain aging are... -
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- Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis
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Lim CJ, Lee YM, Kang SG, Lim HW, Shin KO, Jeong SK, Huh YH, Choi S, Kor M, Seo HS, Park BD, Park K, Ahn JK, Uchida Y, Park K
- KMID: 2389383
- Biomol Ther.
- 2017 Sep;25(5):511-518.
- doi: 10.4062/biomolther.2017.119
Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- and silent information regulator T1 (SIRT1)-dependent pathways are critical cellular processes of not only... -
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- Can we rejuvenate? Implications of biological aging research
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Son Y, Kim JR
- KMID: 2400323
- Yeungnam Univ J Med.
- 2017 Jun;34(1):1-10.
- doi: 10.12701/yujm.2017.34.1.1
The life history of man is summarized as a birth-aging-disease-death. Man eventually ages and dies. How long can humans live? What is aging? Why do we age? Is aging inevitable?... -
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- Subcellular Distribution of Microtubule in Artificially Induced Senescent PC12 Cells
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Lee E, Oh CS, Shin DH, Lee YS
- KMID: 2338530
- J Korean Geriatr Soc.
- 2006 Dec;10(4):278-284.
Background: Since recent reports showed the possibility that cytoskeletal proteins, which were known to be exclusively within the cytoplasm, might play a role in the re-distribution of the intranuclear chromatin... -
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