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Participation of COX-1 and COX-2 in the contractile effect of phenylephrine in prepubescent and old rats

Guevara-Balcazar G, Ramirez-Sanchez I, Mera-Jimenez E, Rubio-Gayosso I, Aguilar-Najera ME, Castillo-Hernandez MC

Vascular reactivity can be influenced by the vascular region, animal age, and pathologies present. Prostaglandins (produced by COX-1 and COX-2) play an important role in the contractile response to phenylephrine...
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