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Protective effects of lutein against vancomycin-induced acute renal injury in mice via upregulation of peroxisome proliferatoractivated receptor gamma/nuclear factor erythroid 2-related factor 2 and inhibition nuclear factor-kappaB/caspase 3

Emeka PM, Rasool ST, Morsy MA, Hairul Islam MI, Chohan MS

Vancomycin, an antibiotic used occasionally as a last line of treatment for methicillin-resistant Staphylococcus aureus, is reportedly associated with nephrotoxicity. This study aimed at evaluating the protective effects of lutein...
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High Serum Levels of Serum 100 Beta Protein, Neuron-specific Enolase, Tau, Active Caspase-3, M30 and M65 in Children with Autism Spectrum Disorders

Ayaydın H, Kirmit A, Çelik H, Akaltun , Koyuncu , Ulgar

Objective: The purpose of this study was therefore to investigate whether neuronal, axonal, and glial cell markers (Neuron-specific enolase [NSE], tau, serum 100 beta protein [S100B], respectively) and apoptosis markers...
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MiR-484 Protects Rat Myocardial Cells from Ischemia-Reperfusion Injury by Inhibiting Caspase-3 and Caspase-9 during Apoptosis

Liu H, Li S, Jiang W, Li Y

BACKGROUND AND OBJECTIVES: To reveal the detail mechanism of miR-484 on myocardial ischemia-reperfusion (MI/R) injury. METHODS: Rats model of MI/R injury was established based on control (Con; sham operate) group, ischemia-reperfusion...
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Survival of isolated human preantral follicles after vitrification: Analyses of morphology and Fas ligand and caspase-3 mRNA expression

Wiweko B, Soebijanto S, Boediono A, Mansyur M, Siregar NC, Suryandari DA, Aulia A, Djuwantono T, Affandi B

OBJECTIVE: This study aimed to examine the effect of vitrification on apoptosis and survival in human preantral follicles after thawing. METHODS: This experimental study was conducted at an acute tertiary care...
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Molecular and Functional Characterization of Choline Transporter-Like Proteins in Esophageal Cancer Cells and Potential Therapeutic Targets

Nagashima , Nishiyama , Iwao B, Kawai Y, Ishii C, Yamanaka T, Uchino H, Inazu M

In this study, we examined the molecular and functional characterization of choline uptake in the human esophageal cancer cells. In addition, we examined the influence of various drugs on the...
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Fucoidan attenuates 6-hydroxydopamine-induced neurotoxicity by exerting anti-oxidative and anti-apoptotic actions in SH-SY5Y cells

Kim MH, Namgoong H, Jung BD, Kwon MS, Choi YS, Shin T, Kim HC, Wie MB

Parkinson's disease (PD) is an irreversible neurological disorder with related locomotor dysfunction and is haracterized by the selective loss of nigral neurons. PD can be experimentally induced by 6-hydroxydopamine (6-OHDA)....
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Isoflurane Preconditioning Induces Neuroprotection by Up-Regulation of TREK1 in a Rat Model of Spinal Cord Ischemic Injury

Wang K, Kong X

This study aimed to explore the neuroprotection and mechanism of isoflurane on rats with spinal cord ischemic injury. Total 40 adult male Sprague-Dawley rats were divided into the four groups...
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Apoptotic Effects of 6-Gingerol in Human Breast Cancer Cells

Kim HW, Oh DH, Koh JT, Lim YC

6-Gingerol exerts anti-tumor effects in various cancer cell models. We evaluated the effect of 6-gingerol on the growth of MCF-7 breast cancer cells and MCF-10A breast epithelial cells to determine...
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Neuroprotective Effect of Steamed and Fermented Codonopsis lanceolata

Weon JB, Yun BR, Lee J, Eom MR, Ko HJ, Lee HY, Park DS, Chung HC, Chung JY, Ma CJ

  • KMID: 2170643
  • Biomol Ther.
  • 2014 May;22(3):246-253.
Codonopsis lanceolata has been used as an herbal medicine for several lung infl ammatory diseases, such as asthma, tonsillitis, and pharyngitis. Previously, we showed the neuroprotective effect of steamed and...
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Protective Effects of Verapamil against H2O2-Induced Apoptosis in Human Lens Epithelial Cells

Wang Z, Wang D, Li Y, Zhang X

Verapamil is used in the treatment of hypertension, angina pectoris, and atrial fibrillation. Recently, several studies have demonstrated that verapamil increased the optic nerve head blood flow and improved the...
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Isoflurane decreases apoptosis of human embryonic stem cell-derived cardiac progenitor cell under oxidative stress

Koo BW, Kim JH, Han SH, Kim MH, Baik JS

  • KMID: 1795955
  • Anesth Pain Med.
  • 2013 Jul;8(3):175-180.
BACKGROUND: Despite the great potential of human embryonic stem cell (hESC)-derived cardiac progenitor cells (CPCs) in the cardiac cell transplantation, the low graft survival still remains as one of the...
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TRPV1 Activation in Primary Cortical Neurons Induces Calcium-Dependent Programmed Cell Death

Song J, Lee JH, Lee SH, Park KA, Lee WT, Lee JE

Transient receptor potential cation channel, subfamily V, member 1 (TRPV1, also known as vanilloid receptor 1) is a receptor that detects capsaicin, a pungent component of chili peppers, and noxious...
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Cathepsin B is activated as an executive protease in fetal rat alveolar type II cells exposed to hyperoxia

Lee HS, Kim CK

Alveolar type II cells are main target of hyperoxia-induced lung injury. The authors investigated whether lysosomal protease, cathepsin B (CB), is activated in fetal alveolar type II cells in the...
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Apoptotic Effects of 6-Gingerol in LNCaP Human Prostate Cancer Cells

Kim HW, Oh DH, Jung C, Kwon DD, Lim YC

  • KMID: 2317616
  • Soonchunhyang Med Sci.
  • 2011 Dec;17(2):75-79.
OBJECTIVE: 6-Gingerol, one component of ginger (Zingiber officinale) compound, has been known to possess anti-inflammatory, analgesic, anti-emetic, and anti-cancer effects. In this study, the apoptotic ability of 6-gingerol was investigated...
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Neonatal Rat Necrotizing Enterocolitis Model Adopting Oral Endotoxin and Hypoxia Exhibits Increased Apoptosis through Caspase-3 Activation

Lee YK, Kim EK, Kim JE, Kim YJ, Son SH, Kim HS, Kim BI, Choi JH

  • KMID: 2144467
  • J Korean Soc Neonatol.
  • 2010 May;17(1):44-52.
PURPOSE: The aim of this study was to develop a model for necrotizing enterocolitis (NEC) in the neonatal rat using endotoxin and hypoxia, a plausible insult in a neonatal intensive...
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Retinal Protective Effects of Minocycline via Anti-apoptosis on Oxygen-induced Retinopathy in Neonatal Rats

Jang YY, Suh ES, Kim WT

  • KMID: 2072248
  • Korean J Perinatol.
  • 2010 Mar;21(1):26-39.
PURPOSE: Retinopathy of prematurity (ROP) is a leading cause of blindness with retinal detachment due to oxygen toxicity in preterm infants. Recently advances in neonatal care had to led improved...
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The effects of gabapentin pretreatment on brain injury induced by focal cerebral ischemia/reperfusion in the rat

Kim YK, Leem JG, Sim JY, Jeong SM, Joung KW

BACKGROUND: Experimental studies have shown that gabapentin can reduce neuronal injury in the setting of cerebral ischemia, but the mechanisms have not yet been clearly determined. This study was conducted...
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The neuroprotective effect of recombinant human erythropoietin via an antiapoptotic mechanism on hypoxic-ischemic brain injury in neonatal rats

Kim MS, Seo YK, Park HJ, Lee KH, Lee KH, Choi EJ, Kim JK, Chung HL, Kim WT

PURPOSE: The neuroprotective effects of erythropoietin (EPO) have been recently shown in many animal models of brain injury, including hypoxic-ischemic (HI) encephalopathy, trauma, and excitotoxicity; however, limited data are available...
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beta-Glucan enhanced apoptosis in human colon cancer cells SNU-C4

Kim MJ, Hong SY, Kim SK, Cheong C, Park HJ, Chun HK, Jang KH, Yoon BD, Kim CH, Kang SA

  • KMID: 2313395
  • Nutr Res Pract.
  • 2009 Sep;3(3):180-184.
The apoptotic effect of bacteria-derived beta-glucan was investigated in human colon cancer cells SNU-C4 using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay, reverse transcription-polymerase chain reaction (RT-PCR)...
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Characterization of Gentamicin-Induced Apoptosis in a Cochlear Cell Model

Nam SI, Song DK, Park SH, Lee JH, Lee WK, Kim EM, Park JS

BACKGROUND AND OBJECTIVES: Aminoglycoside antibiotics are ototoxic. Understanding of the molecular mechanisms underlying the drug-induced ototoxicity, however, has been hampered by limited cell availability. Recently, HEI-OC1 cells, which are of...
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