- Dexpanthenol protects against lipopolysaccharide-induced acute kidney injury by restoring aquaporin-2 levels via regulation of the silent information regulator 1 signaling pathway
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Özden ES, Aşcı H, Büyükbayram H, Sevük MA, İmeci OB, Doğan HK, Özmen
- KMID: 2548314
- Korean J Anesthesiol.
- 2023 Oct;76(5):501-509.
- doi: 10.4097/kja.23207
Background: Acute kidney injury (AKI) is a serious pathology that causes dysfunction in concentrating urine due to kidney damage, resulting in blood pressure dysregulation and increased levels of toxic metabolites.... -
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- Evaluation Expression of the Caspase-3 and Caspase-9 Apoptotic Genes in Schizophrenia Patients
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Dirican E, Özcan H, Uzunçakmak SK, Takım U
- KMID: 2539661
- Clin Psychopharmacol Neurosci.
- 2023 Feb;21(1):171-178.
- doi: 10.9758/cpn.2023.21.1.171
Objective: Apoptosis is programmed cell death that occurs by several pathways. Caspase-3 is induced by active caspase-9 via the intrinsic pathway. The aim of this research was to explore the... -
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- Protective effects of lutein against vancomycin-induced acute renal injury in mice via upregulation of peroxisome proliferatoractivated receptor gamma/nuclear factor erythroid 2-related factor 2 and inhibition nuclear factor-kappaB/caspase 3
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Emeka PM, Rasool ST, Morsy MA, Hairul Islam MI, Chohan MS
- KMID: 2516871
- Korean J Physiol Pharmacol.
- 2021 Jul;25(4):321-331.
- doi: 10.4196/kjpp.2021.25.4.321
Vancomycin, an antibiotic used occasionally as a last line of treatment for methicillin-resistant Staphylococcus aureus, is reportedly associated with nephrotoxicity. This study aimed at evaluating the protective effects of lutein... -
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- High Serum Levels of Serum 100 Beta Protein, Neuron-specific Enolase, Tau, Active Caspase-3, M30 and M65 in Children with Autism Spectrum Disorders
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Ayaydın H, Kirmit A, Çelik H, Akaltun , Koyuncu , Ulgar
- KMID: 2502152
- Clin Psychopharmacol Neurosci.
- 2020 May;18(2):270-278.
- doi: 10.9758/cpn.2020.18.2.270
Objective: The purpose of this study was therefore to investigate whether neuronal, axonal, and glial cell markers (Neuron-specific enolase [NSE], tau, serum 100 beta protein [S100B], respectively) and apoptosis markers... -
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- MiR-484 Protects Rat Myocardial Cells from Ischemia-Reperfusion Injury by Inhibiting Caspase-3 and Caspase-9 during Apoptosis
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Liu H, Li S, Jiang W, Li Y
- KMID: 2470910
- Korean Circ J.
- 2020 Mar;50(3):250-263.
- doi: 10.4070/kcj.2019.0107
BACKGROUND AND OBJECTIVES: To reveal the detail mechanism of miR-484 on myocardial ischemia-reperfusion (MI/R) injury. METHODS: Rats model of MI/R injury was established based on control (Con; sham operate) group, ischemia-reperfusion... -
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- Survival of isolated human preantral follicles after vitrification: Analyses of morphology and Fas ligand and caspase-3 mRNA expression
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Wiweko B, Soebijanto S, Boediono A, Mansyur M, Siregar NC, Suryandari DA, Aulia A, Djuwantono T, Affandi B
- KMID: 2469591
- Clin Exp Reprod Med.
- 2019 Dec;46(4):152-165.
- doi: 10.5653/cerm.2019.00143
OBJECTIVE: This study aimed to examine the effect of vitrification on apoptosis and survival in human preantral follicles after thawing. METHODS: This experimental study was conducted at an acute tertiary care... -
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- Molecular and Functional Characterization of Choline Transporter-Like Proteins in Esophageal Cancer Cells and Potential Therapeutic Targets
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Nagashima , Nishiyama , Iwao B, Kawai Y, Ishii C, Yamanaka T, Uchino H, Inazu M
- KMID: 2420391
- Biomol Ther.
- 2018 Jul;26(4):399-408.
- doi: 10.4062/biomolther.2017.113
In this study, we examined the molecular and functional characterization of choline uptake in the human esophageal cancer cells. In addition, we examined the influence of various drugs on the... -
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- Fucoidan attenuates 6-hydroxydopamine-induced neurotoxicity by exerting anti-oxidative and anti-apoptotic actions in SH-SY5Y cells
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Kim MH, Namgoong H, Jung BD, Kwon MS, Choi YS, Shin T, Kim HC, Wie MB
- KMID: 2376872
- Korean J Vet Res.
- 2017 Mar;57(1):1-7.
- doi: 10.14405/kjvr.2017.57.1.1
Parkinson's disease (PD) is an irreversible neurological disorder with related locomotor dysfunction and is haracterized by the selective loss of nigral neurons. PD can be experimentally induced by 6-hydroxydopamine (6-OHDA).... -
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- Isoflurane Preconditioning Induces Neuroprotection by Up-Regulation of TREK1 in a Rat Model of Spinal Cord Ischemic Injury
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Wang K, Kong X
- KMID: 2351673
- Biomol Ther.
- 2016 Sep;24(5):495-500.
- doi: 10.4062/biomolther.2015.206
This study aimed to explore the neuroprotection and mechanism of isoflurane on rats with spinal cord ischemic injury. Total 40 adult male Sprague-Dawley rats were divided into the four groups... -
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- Apoptotic Effects of 6-Gingerol in Human Breast Cancer Cells
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Kim HW, Oh DH, Koh JT, Lim YC
- KMID: 2133228
- Int J Oral Biol.
- 2015 Dec;40(4):223-228.
- doi: 10.11620/IJOB.2015.40.4.223
6-Gingerol exerts anti-tumor effects in various cancer cell models. We evaluated the effect of 6-gingerol on the growth of MCF-7 breast cancer cells and MCF-10A breast epithelial cells to determine... -
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- Protective Effects of Verapamil against H2O2-Induced Apoptosis in Human Lens Epithelial Cells
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Wang Z, Wang D, Li Y, Zhang X
- KMID: 2170598
- Biomol Ther.
- 2014 Nov;22(6):553-557.
- doi: 10.4062/biomolther.2014.033
Verapamil is used in the treatment of hypertension, angina pectoris, and atrial fibrillation. Recently, several studies have demonstrated that verapamil increased the optic nerve head blood flow and improved the... -
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- Neuroprotective Effect of Steamed and Fermented Codonopsis lanceolata
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Weon JB, Yun BR, Lee J, Eom MR, Ko HJ, Lee HY, Park DS, Chung HC, Chung JY, Ma CJ
- KMID: 2170643
- Biomol Ther.
- 2014 May;22(3):246-253.
Codonopsis lanceolata has been used as an herbal medicine for several lung infl ammatory diseases, such as asthma, tonsillitis, and pharyngitis. Previously, we showed the neuroprotective effect of steamed and... -
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- Isoflurane decreases apoptosis of human embryonic stem cell-derived cardiac progenitor cell under oxidative stress
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Koo BW, Kim JH, Han SH, Kim MH, Baik JS
- KMID: 1795955
- Anesth Pain Med.
- 2013 Jul;8(3):175-180.
BACKGROUND: Despite the great potential of human embryonic stem cell (hESC)-derived cardiac progenitor cells (CPCs) in the cardiac cell transplantation, the low graft survival still remains as one of the... -
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- TRPV1 Activation in Primary Cortical Neurons Induces Calcium-Dependent Programmed Cell Death
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Song J, Lee JH, Lee SH, Park KA, Lee WT, Lee JE
- KMID: 2165442
- Exp Neurobiol.
- 2013 Mar;22(1):51-57.
- doi: 10.5607/en.2013.22.1.51
Transient receptor potential cation channel, subfamily V, member 1 (TRPV1, also known as vanilloid receptor 1) is a receptor that detects capsaicin, a pungent component of chili peppers, and noxious... -
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- Apoptotic Effects of 6-Gingerol in LNCaP Human Prostate Cancer Cells
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Kim HW, Oh DH, Jung C, Kwon DD, Lim YC
- KMID: 2317616
- Soonchunhyang Med Sci.
- 2011 Dec;17(2):75-79.
OBJECTIVE: 6-Gingerol, one component of ginger (Zingiber officinale) compound, has been known to possess anti-inflammatory, analgesic, anti-emetic, and anti-cancer effects. In this study, the apoptotic ability of 6-gingerol was investigated... -
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- Cathepsin B is activated as an executive protease in fetal rat alveolar type II cells exposed to hyperoxia
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Lee HS, Kim CK
- KMID: 1104392
- Exp Mol Med.
- 2011 Apr;43(4):223-229.
- doi: 10.3858/emm.2011.43.4.027
Alveolar type II cells are main target of hyperoxia-induced lung injury. The authors investigated whether lysosomal protease, cathepsin B (CB), is activated in fetal alveolar type II cells in the... -
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- The neuroprotective effect of recombinant human erythropoietin via an antiapoptotic mechanism on hypoxic-ischemic brain injury in neonatal rats
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Kim MS, Seo YK, Park HJ, Lee KH, Lee KH, Choi EJ, Kim JK, Chung HL, Kim WT
- KMID: 2011554
- Korean J Pediatr.
- 2010 Oct;53(10):898-908.
- doi: 10.3345/kjp.2010.53.10.898
PURPOSE: The neuroprotective effects of erythropoietin (EPO) have been recently shown in many animal models of brain injury, including hypoxic-ischemic (HI) encephalopathy, trauma, and excitotoxicity; however, limited data are available... -
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- Neonatal Rat Necrotizing Enterocolitis Model Adopting Oral Endotoxin and Hypoxia Exhibits Increased Apoptosis through Caspase-3 Activation
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Lee YK, Kim EK, Kim JE, Kim YJ, Son SH, Kim HS, Kim BI, Choi JH
- KMID: 2144467
- J Korean Soc Neonatol.
- 2010 May;17(1):44-52.
PURPOSE: The aim of this study was to develop a model for necrotizing enterocolitis (NEC) in the neonatal rat using endotoxin and hypoxia, a plausible insult in a neonatal intensive... -
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- Retinal Protective Effects of Minocycline via Anti-apoptosis on Oxygen-induced Retinopathy in Neonatal Rats
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Jang YY, Suh ES, Kim WT
- KMID: 2072248
- Korean J Perinatol.
- 2010 Mar;21(1):26-39.
PURPOSE: Retinopathy of prematurity (ROP) is a leading cause of blindness with retinal detachment due to oxygen toxicity in preterm infants. Recently advances in neonatal care had to led improved... -
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- The effects of gabapentin pretreatment on brain injury induced by focal cerebral ischemia/reperfusion in the rat
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Kim YK, Leem JG, Sim JY, Jeong SM, Joung KW
- KMID: 2092275
- Korean J Anesthesiol.
- 2010 Feb;58(2):184-190.
- doi: 10.4097/kjae.2010.58.2.184
BACKGROUND: Experimental studies have shown that gabapentin can reduce neuronal injury in the setting of cerebral ischemia, but the mechanisms have not yet been clearly determined. This study was conducted... -
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