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MicroRNA-130a Increases and Predicts Cardiotoxicity during Adjuvant Chemotherapy in Human Epidermal Growth Factor Receptor-2-Positive Breast Cancer

Feng Q, Ren Y, Hou A, Guo J, Mao Z, Liu S, Wang B, Bai Z, Hou X

Purpose: This study aimed to investigate the changes in microRNA-130a (miR-130a) and its correlation with cardiotoxicity during epirubicin/cyclophosphamide followed by docetaxel plus trastuzumab (EC-D+T) adjuvant chemotherapy in human epidermal growth...
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Sex-dependent liver cancer xenograft models for predicting clinical data in the evaluation of anticancer drugs

Oh S, Jung J

Background The incidence and mortality of liver cancer show a great difference between the sexes. We established sex-dependent liver cancer xenograft models and investigated whether such sex-dependent models could be used...
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Cisplatin-induced Atrioventricular Block Requiring a Pacemaker: Two Case Reports and a Literature Review

Bang HJ, Lee HY, Kim HJ, Yoon N, Chung IJ, Bae WK

Chemotherapeutic drugs can cause cardiac toxicities such as cardiomyopathy, arrhythmia, and cardiovascular disease. The well-known side effects of cisplatin are nephrotoxicity, nausea, vomiting, and electrolyte imbalance. Cardiotoxicity induced by cisplatin...
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Antitumor profiles and cardiac electrophysiological effects of aurora kinase inhibitor ZM447439

Lee HA, Kwon M, Kim HA, Kim KS

Aurora kinases inhibitors, including ZM447439 (ZM), which suppress cell division, have attracted a great deal of attention as potential novel anti-cancer drugs. Several recent studies have confirmed the anti-cancer effects...
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Clinical and pharmacological application of multiscale multiphysics heart simulator, UT-Heart

Okada JI, Washio T, Sugiura S, Hisada T

A heart simulator, UT-Heart, is a finite element model of the human heart that can reproduce all the fundamental activities of the working heart, including propagation of excitation, contraction, and...
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Early Decline in Left Ventricular Ejection Fraction Can Predict Trastuzumab-Related Cardiotoxicity in Patients with Breast Cancer: A Study Using 13 Years of Registry Data

Kim EK, Cho J, Kim JY, Chang SA, Park SJ, Choi JO, Lee SC, Ahn JS, Park SW, Im YH, Jeon ES, Park YH

PURPOSE: While concerns regarding trastuzumab-related cardiac dysfunction (TRCD) in patients with breast cancer are increasing, there is a lack of evidence supporting the current recommendations for TRCD monitoring. We aimed...
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Introduction to in silico model for proarrhythmic risk assessment under the CiPA initiative

Park JS, Jeon JY, Yang JH, Kim MG

In 2005, the International Council for Harmonization (ICH) established cardiotoxicity assessment guidelines to identify the risk of Torsade de Pointes (TdP). It is focused on the blockade of the human...
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Correlation of UGT2B7 Polymorphism with Cardiotoxicity in Breast Cancer Patients Undergoing Epirubicin/Cyclophosphamide-Docetaxel Adjuvant Chemotherapy

Li H, Hu B, Guo Z, Jiang X, Su X, Zhang X

PURPOSE: The present study aimed to investigate correlations between uridine glucuronosyltransferase 2B7 (UGT2B7) -161 single nucleotide polymorphism C to T (C>T) and the occurrence of cardiotoxicity in Chinese breast cancer...
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Which Patients with Left Breast Cancer Should be Candidates for Heart-Sparing Radiotherapy?

Cho WK, Park W, Choi DH, Cha H, Nam SJ, Kim SW, Lee JE, Yu J, Im YH, Ahn JS, Park YH, Kim JY

PURPOSE: This study aimed to identify risk factors that have significant interaction with radiation exposure to the heart, and thus to determine candidates for heart-sparing radiotherapy (RT) among women with...
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Comparision of doxorubicin-induced cardiotoxicity in the ICR mice of different sources

Kim SH, Kim KJ, Kim JH, Kwak JH, Song H, Cho JY, Hwang DY, Kim KS, Jung YS

Doxorubicin is a widely used chemotherapeutic agents and is now part of standard therapeutic regimens for a variety of cancers (eg, hematopoietic malignancies and advanced solid tumors of the breast,...
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A Fatal Case of Colchicine Poisoning

Ko SH, Lee GW

Colchicine is a drug that has long been used to treat a variety of illnesses; however, it reportedly has adverse effects at apparent toxic doses as well as at lower...
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Cardioprotective Effect of Dexrazoxane in Patients with HER2-Positive Breast Cancer Who Receive Anthracycline Based Adjuvant Chemotherapy Followed by Trastuzumab

Kim IH, Lee JE, Youn HJ, Song BJ, Chae BJ

PURPOSE: We intended to determine whether dexrazoxane (DZR) is cardioprotective during administration of adjuvant anthracycline-based chemotherapy followed by a 1-year trastuzumab treatment. METHODS: The medical records of 228 patients who underwent...
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Loss of endogenous estrogen increases cardiac toxicity by doxorubicin

Lee YH, Lee SR, Kwon SW, Lee SY, Park BK, Hong EJ

Breast cancer is of enormous concern worldwide and linked with age, sex, hormonal factors, and family history. The treatment of early breast cancer includes treating the disease locally with surgery,...
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Pathophysiology and preventive strategies of anthracycline-induced cardiotoxicity

Chung WB, Youn HJ

Cardiotoxicity is a well-known complication following treatment with anthracyclines. However, they are still widely used in chemotherapy for breast cancer, lymphoma, leukemia, and sarcoma, among others. Patient clinical characteristics, such...
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Chemotherapy-Induced Left Ventricular Dysfunction in Patients with Breast Cancer

Yoon HJ, Kim KH, Kim JY, Park HJ, Cho JY, Hong YJ, Park HW, Kim JH, Ahn Y, Jeong MH, Cho JG, Park JC

PURPOSE: As the numbers of cancer cases and survivors increase, the incidence and natural history of chemotherapy-induced cardiotoxicities in patients with breast cancer may also be expected to change. The...
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Characteristics of Electrocardiographic Changes in Myocardial Injury with Acute Carbon Monoxide Poisoning

Choi IK, Choi HJ

PURPOSE: Electrocardiographic findings such as Tp-Te interval, Tp-Te dispersion, and Tp-Te/QT ratio could be used to predict dysrhythmic events regarding any kind of toxic materials. We investigated the prevalence of...
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Risk of Trastuzumab-Related Cardiotoxicity in Early Breast Cancer Patients: A Prospective Observational Study

Xue J, Jiang Z, Qi F, Lv S, Zhang S, Wang T, Zhang X

PURPOSE: In the present study, we investigated the incidence of cardiotoxicity within 5 years of trastuzumab treatment and evaluated potential risk factors in clinical practice. METHODS: The study cohort included 415...
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Role of Echocardiography in the Management of Cardiac Disease in Women

Shim WJ

The widespread use of echocardiography has contributed to the early recognition of several distinct cardiac diseases in women. During pregnancy, safe monitoring of the disease process, as well as a...
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Cardiotoxicity of Mitoxantrone Treatment in a German Cohort of 639 Multiple Sclerosis Patients

Fleischer , Salmen A, Kollar S, Weyer V, Siffrin V, Chan A, Zipp F, Luessi F

BACKGROUND AND PURPOSE: The aim of this study was to elucidate the role of therapy-related cardiotoxicity in multiple sclerosis (MS) patients treated with mitoxantrone and to identify potential predictors for...
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Early Cardiac Function Monitoring for Detection of Subclinical Doxorubicin Cardiotoxicity in Young Adult Patients with Breast Cancer

Chung WB, Yi JE, Jin JY, Choi YS, Park CS, Park WC, Song BJ, Youn HJ

PURPOSE: As doxorubicin cardiotoxicity is considered irreversible, early detection of cardiotoxicity and prevention of overt heart failure is essential. Although there are monitoring guidelines for cardiotoxicity, optimal timing for early...
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