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Comparative Characterization of Four Calcium-Binding EF Hand Proteins from Opisthorchis viverrini

Emmanoch P, Kosa N, Vichasri-Grams S, Tesana S, Grams R, Geadkaew-Krenc A

Four isoforms of calcium binding proteins containing 2 EF hand motifs and a dynein light chain-like domain in the human liver fluke Opisthorchis viverrini, namely OvCaBP1, 2, 3, and 4,...
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Functional Analysis and Immunochemical Analyses of Ca²⁺ Homeostasis-Related Proteins Expression of Glaucoma-Induced Retinal Degeneration in Rats

Lee JY, Oh SJ

The retinal degeneration resulting from elevated intraocular pressure was evaluated through functional and morphological analyses, for better understanding of the pathophysiology of glaucoma. Ocular hypertension was induced via unilateral episcleral...
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The distribution of calbindin-D28k, parvalbumin, and calretinin immunoreactivity in the inferior colliculus of circling mouse

Lee JK, Kim MJ

The circling mice with tmie gene mutation are known as an animal deafness model, which showed hyperactive circling movement. Recently, the reinvestigation of circling mouse was performed to check the...
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Hornerin Is Involved in Breast Cancer Progression

Choi J, Kim DI, Kim J, Kim BH, Kim A

PURPOSE: The S100 gene family, which comprises over 20 members, including S100A1, S100A2, S100A8, S100A9, profilaggrin, and hornerin encodes low molecular weight calcium-binding proteins with physiological and pathological roles in...
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Changes in the Expressions of Iba1 and Calcitonin Gene-Related Peptide in Adjacent Lumbar Spinal Segments after Lumbar Disc Herniation in a Rat Model

Cho HK, Ahn SH, Kim SY, Choi MJ, Hwang SJ, Cho YW

Lumbar disc herniation is commonly encountered in clinical practice and can induce sciatica due to mechanical and/or chemical irritation and the release of proinflammatory cytokines. However, symptoms are not confined...
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Degradation of the Transcription Factors NF-kappaB, STAT3, and STAT5 Is Involved in Entamoeba histolytica-Induced Cell Death in Caco-2 Colonic Epithelial Cells

Kim KA, Min A, Lee YA, Shin MH

Entamoeba histolytica is a tissue-invasive protozoan parasite causing dysentery in humans. During infection of colonic tissues, amoebic trophozoites are able to kill host cells via apoptosis or necrosis, both of...
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PPARgamma modulates vascular smooth muscle cell phenotype via a protein kinase G-dependent pathway and reduces neointimal hyperplasia after vascular injury

Yang HM, Kim BK, Kim JY, Kwon YW, Jin S, Lee JE, Cho HJ, Lee HY, Kang HJ, Oh BH, Park YB, Kim HS

  • KMID: 2154284
  • Exp Mol Med.
  • 2013 Nov;45(11):e65.
Vascular smooth muscle cells (VSMCs) undergo phenotypic changes in response to vascular injury such as angioplasty. Protein kinase G (PKG) has an important role in the process of VSMC phenotype...
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MAD2 Expression in Ovarian Carcinoma: Different Expression Patterns and Levels among Various Types of Ovarian Carcinoma and Its Prognostic Significance in High-Grade Serous Carcinoma

Park PE, Jeong JY, Kim SZ, Park JY

  • KMID: 2141002
  • Korean J Pathol.
  • 2013 Oct;47(5):418-425.
BACKGROUND: Mitotic arrest deficiency protein 2 (MAD2) is a key component of spindle assembly checkpoint function, which mediates cell apoptosis through microtubule kinetics. Aberrant expression of MAD2 is believed to...
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Attenuation of Spinal Cord Injury-Induced Astroglial and Microglial Activation by Repetitive Transcranial Magnetic Stimulation in Rats

Kim JY, Choi GS, Cho YW, Cho H, Hwang SJ, Ahn SH

Spinal cord injury (SCI) causes not only loss of sensory and motor function below the level of injury but also chronic pain, which is difficult and challenging of the treatment....
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Yin and Yang: the Gastric X/A-like Cell as Possible Dual Regulator of Food Intake

Stengel A, Tache Y

  • KMID: 2325878
  • J Neurogastroenterol Motil.
  • 2012 Apr;18(2):138-149.
Ingestion of food affects secretion of hormones from enteroendocrine cells located in the gastrointestinal mucosa. These hormones are involved in the regulation of various gastrointestinal functions including the control of...
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Adventitial Fibroblast Abormality in Thoracic Aortic Aneurysms and Aortic Dissections

Suh JH, Yoon JS, Kim HW, Jo KH

BACKGROUND: Development of thoracic aortic aneurysms and aortic dissections (TAAD) is attributed to unbearable wall tension superimposed on defective aortic wall integrity and impaired aortic repair mechanisms. Central to this...
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Novel Compound Heterozygote Mutations of the SLC25A13 Gene in an Infant with Neonatal-onset Type II Citrullinemia Detected by Newborn Mass Screening

Lim HS, Kim H, Kim SS, Kim GH, Yoo HW, Shin YL

Citrin deficiency caused by the SLC25A13 gene mutations is associated with both neonatal-onset type II citrullinemia (CTLN2), also known as neonatal intrahepatic cholestasis caused by citrin deficiency and adult-onset CTLN2....
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Expression of Pro-inflammatory Protein S100A12 (EN-RAGE) in Behcet's Disease and Its Association with Disease Activity: A Pilot Study

Han EC, Cho SB, Ahn KJ, Oh SH, Kim J, Kim DS, Lee KH, Bang D

BACKGROUND: S100A12 is a member of the S100 family of calcium-binding proteins and is secreted either in inflamed tissues or in the bloodstream by activated neutrophils. Expression of S100A12 has...
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Immunohistochemical study on the expression of calcium binding proteins (calbindin-D28k, calretinin, and parvalbumin) in the cerebral cortex and in the hippocampal region of nNOS knock-out(-/-) mice

Cho YJ, Lee JC, Kang BG, An J, Song HS, Son O, Nam DH, Cha CI, Joo KM

Nitric oxide (NO) modulates the activities of various channels and receptors to participate in the regulation of neuronal intracellular Ca2+ levels. Ca2+ binding protein (CaBP) expression may also be altered...
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Immunochemical changes of calbindin, calretinin and SMI32 in ischemic retinas induced by increase of intraocular pressure and by middle cerebral artery occlusion

Lee JH, Shin JM, Shin YJ, Chun MH, Oh SJ

The reaction of neuroactive substances to ischemic conditions in the rat retina evoked by different methods was immunochemically evaluated in adult Sprague-Dawley rats. Ocular ischemic conditions were unilaterally produced by...
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Changes in transcript and protein levels of calbindin D28k, calretinin and parvalbumin, and numbers of neuronal populations expressing these proteins in an ischemia model of rat retina

Kim SA, Jeon JH, Son MJ, Cha J, Chun MH, Kim IB

Excessive calcium is thought to be a critical step in various neurodegenerative processes including ischemia. Calbindin D28k (CB), calretinin (CR), and parvalbumin (PV), members of the EF-hand calcium-binding protein family,...
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Exuberant Smooth Muscle Cells in Fibroadenoma of the Breast: A Case Report

Kim GE, Kim Y, Jeong EH, Kim JH, Park MH, Lee JS

  • KMID: 2277583
  • Korean J Pathol.
  • 2010 Aug;44(4):431-434.
Smooth muscle cell metaplasia is an extremely rare form of stromal differentiation in fibroadenomas. We describe a case of fibroadenoma with exuberant smooth muscle cells in a 72-year-old woman. The...
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Significance of S100A2 and S100A4 Expression in the Progression of Prostate Adenocarcinoma

Kwon YW, Chang IH, Kim KD, Kim YS, Myung SC, Kim MK, Kim TH

  • KMID: 2314649
  • Korean J Urol.
  • 2010 Jul;51(7):456-462.
PURPOSE: The aim of this study was to investigate the expression pattern of calcium-binding proteins S100A2 and S100A4. We also sought to determine the prognostic value of these markers for...
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Expression of calponin in periglomerular myofibroblasts of rat kidney with experimental chronic injuries

Lee SY, Choi JY, Jin DC, Kim J, Cha JH

Our previous research demonstrated that calponin-immunoreactivity was localized in myofibroblasts of the periglomerular region of human kidney specimens obtained at the time of transplantation from organ recipients. In the present...
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Immunohistochemical study on the expression of calcium binding proteins (calbindin-D28k, calretinin, and parvalbumin) in the cerebellum of the nNOS knock-out(-/-) mice

Lee JC, Chung YH, Cho YJ, Kim J, Kim N, Cha CI, Joo KM

Nitric Oxide (NO) actively participates in the regulation of neuronal intracellular Ca2+ levels by modulating the activity of various channels and receptors. To test the possibility that modulation of Ca2+...
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