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Deficiency of Anoctamin 5/TMEM16E causes nuclear positioning defect and impairs Ca²⁺ signaling of differentiated C2C12 myotubes

Phuong TT, An J, Park SH, Kim A, Choi HB, Kang TM

Anoctamin 5 (ANO5)/TMEM16E belongs to a member of the ANO/TMEM16 family member of anion channels. However, it is a matter of debate whether ANO5 functions as a genuine plasma membrane...
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Modulation of Dopaminergic Neuronal Excitability by Zinc through the Regulation of Calcium-related Channels

Noh J, Chung JM

Depending on the intracellular buffering of calcium by chelation, zinc has the following two apparent effects on neuronal excitability: enhancement or reduction. Zinc increased tonic activity in the depolarized state...
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Molecular and Cellular Characteristics of the Colonic Pseudo-obstruction in Patients With Intractable Constipation

Do YS, Myung SJ, Kwak SY, Cho S, Lee E, Song MJ, Yu CS, Yoon YS, Lee HK

  • KMID: 2381305
  • J Neurogastroenterol Motil.
  • 2015 Oct;21(4):560-570.
  • doi: 10.5056/jnm15048
BACKGROUND/AIMS: Chronic intestinal pseudo-obstruction (CIPO) is a disorder characterized by recurrent symptoms suggestive of obstruction such as abdominal pain, proximal distension with extremely suppressed motility in the absence of lumen-occluding...
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Red Liriope platyphylla stimulated the insulin secretion through the regulation of calcium concentration in rat insulinoma cells and animal models

Lee HR, Kim JE, Lee YJ, Kwak MH, Im DS, Hwang DY

The aim of this study was to investigate the effects of Red L. platyphylla (RLP) on calcium and glucose levels during insulin secretion. To achieve this, alteration of insulin and...
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Sudden Cardiac Arrest during Anesthesia in a 30-Month-Old Boy with Syndactyly: A Case of Genetically Proven Timothy Syndrome

An HS, Choi EY, Kwon BS, Kim GB, Bae EJ, Noh CI, Choi JY, Park SS

Timothy syndrome, long QT syndrome type 8, is highly malignant with ventricular tachyarrhythmia. A 30-month-old boy had sudden cardiac arrest during anesthesia induction before plastic surgery for bilateral cutaneous syndactyly....
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Down-Regulation of Survivin by Nemadipine-A Sensitizes Cancer Cells to TRAIL-Induced Apoptosis

Park SH, Park SJ, Kim JO, Shin JH, Kim ES, Jo YK, Kim JS, Park SJ, Jin DH, Hwang JJ, Lee SJ, Jeong SY, Lee C, Kim I, Cho DH

  • KMID: 2170682
  • Biomol Ther.
  • 2013 Jan;21(1):29-34.
The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor family of cytokines. TRAIL selectively induces apoptotic cell death in various tumors and cancer...
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Dendroaspis natriuretic peptide regulates the cardiac L-type Ca2+ channel activity by the phosphorylation of alpha1c proteins

Park SA, Kim TG, Han MK, Ha KC, Kim SZ, Kwak YG

  • KMID: 1383798
  • Exp Mol Med.
  • 2012 Jun;44(6):363-368.
Dendroaspis natriuretic peptide (DNP), a new member of the natriuretic peptide family, is structurally similar to atrial, brain, and C-type natriuretic peptides. However, the effects of DNP on the cardiac...
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Ionic Mechanisms of Desflurane on Prolongation of Action Potential Duration in Rat Ventricular Myocytes

Chae JE, Kim HS, Ahn DS, Park WK

PURPOSE: Despite the fact that desflurane prolongs the QTC interval in humans, little is known about the mechanisms that underlie these actions. We investigated the effects of desflurane on action...
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Intracisternal Administration of Voltage Dependent Calcium Channel Blockers Attenuates Orofacial Inflammatory Nociceptive Behavior in Rats

Won KA, Park SH, Kim BK, Baek KS, Yoon DH, Ahn DK

  • KMID: 2170724
  • Int J Oral Biol.
  • 2011 Jun;36(2):43-50.
Voltage dependent calcium channel (VDCC), one of the most important regulator of Ca2+ concentration in neuron, play an essential role in the central processing of nociceptive information. The present study...
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TRPC3 cation channel plays an important role in proliferation and differentiation of skeletal muscle myoblasts

Woo JS, Cho CH, Kim DH, Lee EH

During membrane depolarization associated with skeletal excitation-contraction (EC) coupling, dihydropyridine receptor [DHPR, a L-type Ca2+ channel in the transverse (t)-tubule membrane] undergoes conformational changes that are transmitted to ryanodine receptor...
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Role of PKG-L-type calcium channels in the antinociceptive effect of intrathecal sildenafil

Kim WM, Yoon MH, Cui JH

Sildenafil increases the cyclic guanosine monophosphate (cGMP) by inhibition of a phosphodiesterase 5, thereby leading to an antinociceptive effect. The increased cGMP may exert the effect on an L-type calcium...
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Effect of Efonidipine on Proteinuria in Patients with Chronic Kidney Disease Receiving RAS Blockade

Wi JK, Jeong KW, Lee TW, Lee SH, Moon JY, Cha DR, Ha SK, Kim SB, Kwak IS, Ihm CG

  • KMID: 1855492
  • Korean J Nephrol.
  • 2010 May;29(3):322-328.
PURPOSE: Efonidipine, which inhibits both T- and L-type calcium channels, has been shown to be effective in reducing proteinuria and preserve renal function. This study was conducted to compare the...
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Mechanical Stretch-Induced Protection against Myocardial Ischemia-Reperfusion Injury Involves AMP-Activated Protein Kinase

Hao J, Kim HS, Choi W, Ha TS, Ahn HY, Kim CH

AMP-activated protein kinase (AMPK) protects various tissues and cells from ischemic insults and is activated by many stimuli including mechanical stretch. Therefore, this study investigated if the activation of AMPK...
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Does a single dose of intravenous nicardipine or nimodipine affect the bispectral index following rapid sequence intubation?

Lee JJ, Kim JA, Ahn HJ, Kim JK, Yang M, Choi SJ, Kim HS, Yang SH

BACKGROUND: Theoretically, L-type calcium channel blockers could modulate anesthetic effects. Nicardipine does not affect the bispectral index (BIS), but nimodipine, which can penetrate the blood-brain barrier, has not been studied....
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Isolation of Voltage Dependent Calcium Current in Chick Inner Hair Cell

Lee SH, Shin MC, Ahn TH, Kim KY, Kim K, Min HJ, Park CW

BACKGROUND AND OBJECTIVES: Voltage dependent calcium channel (VDCC) mediates calcium ion influx and controls neurotransmitter release in excitable cells. Hair cells in vertebrates cochlea are known to express L-type VDCC....
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Angiotensin II-induced aortic ring constriction is mediated by phosphatidylinositol 3-kinase/L-type calcium channel signaling pathway

Do KH, Kim MS, Kim JH, Rhim BY, Lee WS, Kim CD, Bae SS

Angiotensin II (AngII) is a crucial hormone that affects vasoconstriction and exerts hypertrophic effects on vascular smooth muscle cells. Here, we showed that phosphatidylinositol 3-kinase-dependent calcium mobilization plays pivotal roles...
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Protective effect of total aralosides of Aralia elata (Miq) Seem (TASAES) against diabetic cardiomyopathy in rats during the early stage, and possible mechanisms

Xi S, Zhou G, Zhang X, Zhang W, Cai L, Zhao C

Total aralosides of Aralia elata (Miq) Seem (TASAES) from Chinese traditional herb Longya Aralia chinensis L was found to improve cardiac function. The present study was to determine the protective...
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Diclofenac, a Non-steroidal Anti-inflammatory Drug, Inhibits L-type Ca2+ Channels in Neonatal Rat Ventricular Cardiomyocytes

Yarishkin , Hwang EM, Kim D, Yoo JC, Kang SS, Kim DR, Shin JH, Chung HJ, Jeong HS, Kang D, Han J, Park JY, Hong SG

A non-steroidal anti-inflammatory drug (NSAID) has many adverse effects including cardiovascular (CV) risk. Diclofenac among the nonselective NSAIDs has the highest CV risk such as congestive heart failure, which resulted...
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An Arg1239His mutation of the CACNL1A3 gene in a Korean family with hypokalemic periodic paralysis

Yeo CY, Kim YO, Kim MK, Kim JY, Cho YK, Kim CJ, Woo YJ

Familial hypokalemic periodic paralysis (hypoPP) is a rare inherited channelopathy that often presents with episodic weakness accompanied by hypokalemia. Thus far, mutations in the gene encoding two ion channels (CACNL1A3,...
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Proliferation and Differentiation of Pancreatic beta Cells in L-type Calcium Channel alpha(1D) Subunit (Ca(v)1.3) Heterozygous Knock Out Mice After Partial Pancreatectomy

Choi YH, Yun IH, Suh SH, Lim DJ, Cho JH, Kwon HS, Cha BY, Son HY, Park CG, Yoon KH

BACKGROUNDS: L-type voltage-dependent calcium channel (LTCC) plays a crucial role in insulin secretion from pancreatic beta cells through Ca2+ influx. In the recent report, LTCC Ca(v)1.3 subtype homozygous knock out...
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