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Effects of ketamine on contractile responses in vascular smooth muscle

Kang BS, Lee YH, Nam TS, Yeon DS, Hwng SK, Park KS

This study was designed to determine the effects of ketamine on contractions induced by norepinephrine (NE), K+ or histamine (Hist) and on agonist-induced calcium mobilization, in rabbit thoracic aorta with...
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Protective mechanism of glucose against alloxan-induced beta-cell damage: pivotal role of ATP

Rho HW, Lee JN, Kim HR, Park BH, Park JW

  • KMID: 927128
  • Exp Mol Med.
  • 2000 Mar;32(1):12-17.
Glucose prevents the development of diabetes induced by alloxan. In the present study, the protective mechanism of glucose against alloxan-induced beta-cell damage was investigated using HIT-T 15 cell, a Syrian...
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Calpain inhibitors reduce the cornified cell envelope formation by inhibiting proteolytic processing of transglutaminase 1

Kim SY, Bae CD

  • KMID: 755018
  • Exp Mol Med.
  • 1998 Dec;30(4):257-262.
Calpain I (mu-calpain) and II (m-calpain) are well known calcium-activated neutral cysteine proteases. Many reports have shown that activation of calpain is related to cataract formation, neuronal degeneration, blood clotting, ...
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Membrane stretch increases the activity of Ca(2+)-activated K+ channels in rabbit coronary vascular smooth muscles

Lee CJ, Kwon S, Lee YH, Ahn DS, Kang BS

It has been proposed that Ca(2+)-activated K+ channels play an essential role in maintaining vascular tone during stretch of blood vessel. However, the underlying mechanism of stretch-induced change of Ca(2+)-activated...
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Biochemical and Physiological Characteristics of Ca-ATPase System of Rat Liver Mitochondria with Special Attention to the Effects of pH and Temperature

Lee SM, Hwang AR, Kim HJ, Park YS

The activity of Mg++-dependent, Ca++-activated adenosine triphosphatase (Ca-ATPase) of rat liver mitochondria was studied at varying medium compositions, pH and temperatures. The enzyme system was characteristically sensitive to Ca++ concentration...
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The proteins of synaptic vesicle membranes are affected during ageing of rat brain

Lee SR, Kim AR, Kim JS, Kim JB, Lee JY, Lee YL, Choe M, Park JB

  • KMID: 1457533
  • Exp Mol Med.
  • 2001 Dec;33(4):220-225.
Low molecular weight GTP-binding proteins are molecular switches that are believed to play pivotal roles in cell growth, differentiation, cytoskeletal organization, and vesicular trafficking. Rab proteins are key players in...
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PKC alpha induces differentiation through ERK1/2 phosphorylation in mouse keratinocytes

Seo HR, Kwan YW, Cho CK, Bae S, Lee SJ, Soh JW, Chung HY, Lee YS

  • KMID: 1094073
  • Exp Mol Med.
  • 2004 Aug;36(4):292-299.
Epidermal keratinocyte differentiation is a tightly regulated stepwise process that requires protein kinase C (PKC) activation. Studies on cultured mouse keraitnocytes induced to differentiate with Ca2+ have indirectly implicated the...
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