- Effects of Dextran Sulfate Sodium-Induced Ulcerative Colitis on the Disposition of Tofacitinib in Rats
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Bae SH, Kim HS, Choi HG, Chang SY, Kim SH
- KMID: 2534700
- Biomol Ther.
- 2022 Nov;30(6):510-519.
- doi: 10.4062/biomolther.2022.049
Tofacitinib, a Janus kinase 1 and 3 inhibitor, is mainly metabolized by CYP3A1/2 and CYP2C11 in the liver. The drug has been approved for the chronic treatment of severe ulcerative... -
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