- Effects of Cefodizime on Phagocytosis of COS-1 Ccells
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Hwang PH, Nam SY, Yi HK, Kim MH, Kim KS, Kim JS
- KMID: 2104441
- J Korean Pediatr Soc.
- 1998 Dec;41(12):1632-1638.
PURPOSE: Cefodizime is a new third-generation cephalosporin which has a structure and immunomodutation properties similar to cefotaxime. Various studies on cefodizime have demonstrated the direct eradication of bacteria in cooperation... -
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- Remifentanil induces autophagy and prevents hydrogen peroxide-induced apoptosis in Cos-7 cells
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Yoon JY, Baek CW, Woo MN, Kim EJ, Yoon JU, Park CH
- KMID: 2354652
- J Dent Anesth Pain Med.
- 2016 Sep;16(3):175-184.
- doi: 10.17245/jdapm.2016.16.3.175
BACKGROUND: This study investigated the effect of remifentanil pretreatment on Cos-7 cells exposed to oxidative stress, and the influence of remifentanil on intracellular autophagy and apoptotic cell death. METHODS: Cells were... -
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- Retainment of membrane binding capacity of non-palmitoylated Gs alpha mutants expressed in COS-1 cells
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Yang JM, Cho CH, Bae CD, Juhnn YS
- KMID: 755014
- Exp Mol Med.
- 1998 Dec;30(4):235-239.
Heterotrimeric guanine nucleotide binding regulatory proteins (G proteins) transduce extracellular signals into intracellular signals by coupling receptors and effectors. Because most of the G protein-coupled receptors are integral proteins, the... -
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- Propofol Post-conditioning Protects against COS-7 Cells in Hypoxia/reoxygenation Injury by Induction of Intracellular Autophagy
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Kwak JW, Kim EN, Park BS, Kim YH, Kim YD, Yoon JU, Kim CH, Yoon JY
- KMID: 2345004
- J Korean Dent Soc Anesthesiol.
- 2014 Mar;14(1):49-56.
- doi: 10.17245/jkdsa.2014.14.1.49
BACKGROUND: Propofol (2.6-diisopropylphenol) is a widely used intravenous anesthetic agent for the induction and maintenance of anesthesia during surgeries and sedation for ICU patients. Propofol has a structural similarity to... -
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- The Effects of Recombinant Human BMP-7, Prepared from a COS-7 Expression System, on the Proliferation and Differentiation of Rat Newborn Calvarial Osteoblasts
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Lee DH, Suh H, Han DW, Park BJ, Lee JW, Park JC
- KMID: 720897
- Yonsei Med J.
- 2003 Aug;44(4):593-601.
- doi: 10.3349/ymj.2003.44.4.593
A family of proteins, the bone morphogenetic proteins (BMPs), which promote osteoblast differentiation and bone mineralization, have recently been identified. One, BMP-7, has shown the ability to induce cartilage and... -
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- Propofol protects against oxidative-stress-induced COS-7 cell apoptosis by inducing autophagy
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Yoon JY, Baek CW, Kim EJ, Park BS, Yu SB, Yoon JU, Kim EN
- KMID: 2374722
- J Dent Anesth Pain Med.
- 2017 Mar;17(1):37-46.
- doi: 10.17245/jdapm.2017.17.1.37
BACKGROUND: In oxidative stress, reactive oxygen species (ROS) production contributes to cellular dysfunction and initiates the apoptotic cascade. Autophagy is considered the mechanism that decreases ROS concentration and oxidative damage.... -
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- Effects of overexpression of stimulatory G proteins on the expression of the other G proteins in COS-1 cells
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Kim SY, Jang IS, Yang JM, Kwak SJ, Juhnn YS
- KMID: 2045610
- Exp Mol Med.
- 1997 Jun;29(2):133-137.
To investigate the interaction of stimulatory GTP binding protein (G(s)) pathways with others, we overexpressed wild type alpha subunit of G(s) (G(s) alpha), constitutively activated R201E G(s) alpha, and dominant... -
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- Pseudotype HIV-1 Particles Carrying CD4
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Park SW, Kim TG, You JC, Schubert M, Paik SY
- KMID: 1896565
- J Korean Soc Virol.
- 2000 Mar;30(1):83-99.
A defective HIV-1 helper virus DNA, pHyPC, was assembled by deleting the RNA packaging signal, env, nef and the 3'LTR sequences. HIV-1 like virus particles that carry the HIV-1 receptor,... -
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- Cytoplasmic Domain of Intercellular Adhesion Molecule-1(ICAM-1)is Important for the ICAM-1 Mediated Membrane Projection of Endothelial Cells
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Seo GS, Choi M, Oh HM, Lee MH, Lee KM, Nah YH, Jun CD
- KMID: 2030767
- Korean J Anat.
- 2005 Feb;38(1):11-19.
Intercellular adhesion molecule-1 (ICAM-1)has been shown to enhance leukocyte adhesion, thereby inducing migration through blood endothelial cells. However, the molecular event during the process of adhesion is largely unknown. To... -
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- SR144528 as Inverse Agonist of CB2 Cannabinoid Receptor
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Rhee MH, Kim SK
- KMID: 1095119
- J Vet Sci.
- 2002 Sep;3(3):179-184.
It is now well established that several G protein- coupled receptors can signal without agonist stimulation (constitutive receptors). Inverse agonists have been shown to inhibit the activity of such constitutive... -
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- Autoantigenic Role of Variant Thyroperoxidase
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Shong YK, Moon DH, Kim GS
- KMID: 2461605
- J Korean Soc Endocrinol.
- 1996 Mar;11(1):61-67.
Background: Thyroperoxidase(TPO) is one of the most important autoantigens in autoimmune thyroid disorders and autoantibody to TPO is found in almost every patients with various autoimmune thyroid diseases. Human TPO... -
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- Gold compound auranofin inhibits I kappaB kinase (IKK) by modifying Cys-179 of IKK beta subunit
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Jeon KI, Byun MS, Jue DM
- KMID: 1097252
- Exp Mol Med.
- 2003 Apr;35(2):61-66.
Antirheumatic gold compounds have been shown to inhibit NF-kB activation by blocking IkB kinase (IKK) activity. To examine the possible inhibitory mechanism of gold compounds, we expressed wild type and... -
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- Generation of Monoclonal Antibodies Against Human Papillomavirus Type16 E7 Protein : Usefulness for Various E7 Detection Systems
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Chang WH, Cho MK, Kee SH, Kim YW, Lee JC, Kim KH, Kim BG, Park SY
- KMID: 1540529
- J Korean Soc Microbiol.
- 1997 Jun;32(3):335-342.
The gene encoding E7 oncoprotein of human papillomavirus type 16 was cloned and expressed in Escherichia coli, and the monoclonal antibodies (Mabs) against this expressed protein were generated. For the... -
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- Prolonged hypotensive effect of human tissue kallikrein gene delivery and recombinant enzyme administration in spontaneous hypertension rats
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Sun H, Zhang L, Wang A, Xue Z
- KMID: 755661
- Exp Mol Med.
- 2004 Feb;36(1):23-27.
To evaluate the feasibility of treating hypertension by human tissue kallikrein gene (KLK1) delivery and by enzyme (rK1) administration, two recombinant vectors expressing KLK1 cDNA were constructed for gene delivery... -
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- The Inhibition of TREK2 Channel by an Oxidizing Agent, 5,5'-dithio- bis (2-nitrobenzoic acid), via Interaction with the C-terminus Distal to the 353rd Amino Acid
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Park KS, Bang H, Shin EY, Kim CH, Kim Y
- KMID: 1838361
- Korean J Physiol Pharmacol.
- 2008 Aug;12(4):211-216.
- doi: 10.4196/kjpp.2008.12.4.211
TREK (TWIK-RElated K+ channels) and TRAAK (TWIK-Related Arachidonic acid Activated K+ channels) were expressed in COS-7 cells, and the channel activities were recorded from inside-out membrane patches using holding potential... -
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- Construction of Recombinant DNA with F and HN Genes of Newcastle Disease Virus and Its Immunogenicity
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Kim JY, Chu J, Park JH, Seo SH, Park CS, Kim MC, Jun MH
- KMID: 2055016
- J Bacteriol Virol.
- 2006 Jun;36(2):99-107.
- doi: 10.4167/jbv.2006.36.2.99
Recombinant DNA vaccines, based on plasmid vectors expressing an antigen under the control of a strong promotor, have several advantages over traditional vaccines. They have been shown to induce a... -
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- The colchicine derivative CT20126 shows a novel microtubule-modulating activity with apoptosis
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Kim SK, Cho SM, Kim H, Seok H, Kim SO, Kwon TK, Chang JS
- KMID: 2154238
- Exp Mol Med.
- 2013 Apr;45(4):e19.
New colchicine analogs have been synthesized with the aim of developing stronger potential anticancer activities. Among the analogs, CT20126 has been previously reported to show immunosuppressive activities. Here, we report... -
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- Characterization of Monoclonal Antibodies against Human Leukocyte Common Antigen (CD45)
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Shin HM, Cho WD, Lee GK, Lee SH, Lee KM, Ji GY, Yoon SS, Koo JH, Lee HC, Lee KH, Song HG
- KMID: 2150699
- Immune Netw.
- 2011 Apr;11(2):114-122.
- doi: 10.4110/in.2011.11.2.114
BACKGROUND: The leukocyte common antigen (CD45) is a transmembrane-type protein tyrosine phosphatase that has five isoforms. METHODS: We generated seven murine mAbs against human CD45 by injecting cells from different origins,... -
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- Characterization of Molecular Defects in Korean Families with Inherited Ornithine Transcarbamylase Deficiency and Their Genotype-Phenotype Correlations
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Yoo HW
- KMID: 1748172
- J Korean Pediatr Soc.
- 1999 Jul;42(7):900-910.
PURPOSE: This study was undertaken to characterize molecular defects in Korean families with ornithine transcarbamylase(OTC) deficiency, correlate it with phenotype using in vitro expression study, and utilize it for making... -
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- Search for "Proximal Histidine" of Thyroperoxidase Using Site Directed Mutagenesis
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Kim WB, Shong YK
- KMID: 2200381
- J Korean Soc Endocrinol.
- 2003 Aug;18(4):371-378.
BACKGROUND: Thyroperoxidase (TPO), a transmembrane heme containing glycoprotein, catalyzes iodide organification and thyroid hormone synthesis. It is a single peptide making a loop with more than one disulfide bond. The... -
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