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Maintenance of CD8+T-cell anergy by CD4+CD25+ regulatory T cells in chronic graft-versus-host disease

Kim J, Kim HJ, Choi WS, Nam SH, Cho HR, Kwon B

  • KMID: 1098083
  • Exp Mol Med.
  • 2006 Oct;38(5):494-501.
In a murine model of systemic lupus erythematosus (SLE)-like chronic graft-versus-host disease (cGVHD), donor CD8+T cells rapidly fall into anergy to host cells, while donor CD4+T cells hyperactivate B cells...
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The presence of CD8+ invariant NKT cells in mice

Lee H, Hong C, Shin J, Oh S, Jung S, Park YK, Hong S, Lee GR, Park SH

Invariant natural killer T (iNKT) cells develop in the thymus upon recognition of CD1d expressed on developing thymocytes. Although CD4 and CD8 coreceptors are not directly involved in the interaction...
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Expression of Hepatitis C Virus Core Protein in Hepatocytes Does Not Modulate Proliferation or Apoptosis of CD8+ T Cells

Jin YH, Crispe IN, Park S

  • KMID: 2428300
  • Yonsei Med J.
  • 2005 Dec;46(6):827-834.
Hepatocytes are the primary targets of the hepatitis C virus (HCV). While immunosuppressive roles of HCV core protein have been found in several studies, it remains uncertain whether core protein...
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Subdominant H60 antigen-specific CD8 T-cell response precedes dominant H4 antigen-specific response during the initial phase of allogenic skin graft rejection

Yoo KI, Jeon JY, Ryu SJ, Nam G, Youn H, Choi EY

In allogeneic transplantation, including the B6 anti-BALB.B settings, H60 and H4 are two representative dominant minor histocompatibility antigens that induce strong CD8 T-cell responses. With different distribution patterns, H60 expression...
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HBV-specific CD8+ T cells for Sustained HBeAg Seroconversion after Lamivudine Therapy

Lee CK, Han KH, Suh JH, Cho YS, Won SY, Chon CY, Moon YM, Park IS

  • KMID: 760578
  • Korean J Hepatol.
  • 2005 Mar;11(1):34-42.
BACKGROUND/AIMS: Viral suppression of the hepatitis B virus (HBV) can be induced by lamivudine, but the relapse seen in many patients after cessation of lamivudine therapy is troublesome. We...
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CD8+ T-cell Activation in Mice Injected with a Plasmid DNA Vaccine Encoding AMA-1 of the Reemerging Korean Plasmodium vivax

Kim HJ, Jung BK, Lee JJ, Pyo KH, Kim TY, Choi BI, Kim TW, Hisaeda H, Himeno K, Shin EH, Chai JY

Relatively little has been studied on the AMA-1 vaccine against Plasmodium vivax and on the plasmid DNA vaccine encoding P. vivax AMA-1 (PvAMA-1). In the present study, a plasmid DNA...
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Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8+ T cells

Park SN, Noh KT, Jeong YI, Jung ID, Kang HK, Cha GS, Lee SJ, Seo JK, Kang DH, Hwang TH, Lee EK, Kwon B, Park YM

  • KMID: 2154227
  • Exp Mol Med.
  • 2013 Feb;45(2):e8.
We evaluated the effectiveness of rhamnogalacturonan II (RG-II)-stimulated bone marrow-derived dendritic cells (BMDCs) vaccination on the induction of antitumor immunity in a mouse lymphoma model using EG7-lymphoma cells expressing ovalbumin...
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