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Changes in plasma lipoxin A4, resolvins and CD59 levels after ischemic and traumatic brain injuries in rats

Jung JS, Kho AR, Lee SH, Choi BY, Kang SH, Koh JY, Suh SW, Song DK

Ischemic and traumatic brain injuries are the major acute central nervous system disorders that need to be adequately diagnosed and treated. To find biomarkers for these acute brain injuries, plasma...
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Generation of 1E8 Single Chain Fv-Fc Construct Against Human CD59

Hong JW, Cho WD, Hong KP, Kim SS, Son SM, Yun SJ, Lee HC, Yoon SS, Song HG

BACKGROUND: Therapeutic approaches using monoclonal antibodies (mAbs) against complement regulatory proteins (CRPs:i.e.,CD46,CD55 and CD59) have been reported for adjuvant cancer therapy. In this study, we generated a recombinant 1E8 single-chain...
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Role of Complement Regulatory Proteins in the Survival of Murine Allo-transplanted Sertoli Cells

Lee HM, Oh BC, Lim DP, Lee DS, Cho J, Lee G, Lee JR

Sertoli cells (SC) are known to contain immunoprotective properties, which allow them to survive as allografts without the use of immunosuppressive drugs. Experiments were designed to determine which factors are...
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Diagnosis of Paroxysmal Nocturnal Hemoglobinuria (PNH) by the REDQUANT and the CELLQUANT kits

Kim KH, Han JY, Kim JM

  • KMID: 2038252
  • Korean J Lab Med.
  • 2005 Aug;25(4):217-222.
BACKGROUND: Paroximal nocturnal hemoglobinuria (PNH) is a disorder of the pluripotent stem cells resulting in a deficient expression of membrane-bound GPI-anchored proteins in different cell types. We evaluated REDQUANT and...
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The Frequency of Glycophosphatidyl Inositol-Anchored Protein-Negative Paroxysmal Nocturnal Hemoglobinuria Cells in Pediatric Aplastic Anemia Analyzed by Flow Cytometry

Kim SJ, Kook H, Cho D, Kim SY, Noh HY, Choi IS, Lee JS, Ryang DW, Hwang TJ

  • KMID: 2278261
  • Korean J Pediatr Hematol Oncol.
  • 2003 Apr;10(1):39-48.
PURPOSE: Paroxysmal nocturnal hemoglobinuria (PNH) has been known to be a late clonal complication of aplastic anemia (AA). Flow cytometric analysis using CD55 and CD59 antibodies became the gold standard...
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Expression of Complement Regulator Genes in Abeta1-42 Stimulated Human Neuroblastoma Cell

Choi YS, Lee KS, Kim SH

  • KMID: 2343063
  • J Korean Neurol Assoc.
  • 2003 Oct;21(5):513-520.
BACKGROUND: Endogenous complement inhibitors in the brain may protect against the neuroinflammation in Alzheimer's disease. Human neuroblastoma cells were stimulated by Abeta1 - 4 2 to investigate whether the expression...
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CD59 Analysis and Screening of PIG-A Gene Mutation in Aplastic Anemia, Myelodysplastic Syndrome and Paroxysmal Nocturnal Hemoglobinuria

Chang YH, Cho HI, Park SS, Park MH, Lee DS, Lee YJ, Hur M, Kim BK, Park S

  • KMID: 2225943
  • Korean J Clin Pathol.
  • 2000 Jun;20(3):255-262.
BACKGROUND: Aplastic anemia(AA), myelodysplastic syndrome(MDS) and paroxysmal nocturnal hemoglobinuria(PNH) are hematopoietic stem cell disorders. To investigate the pathogenetic links, we performed CD59 analysis and screened PIG-A gene mutation in the...
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CD55 and CD59 : New Diagnostic Tests for Paroxysmal Nocturnal Hemoglobinuria

Kang YH, Park CJ, Chi HS

  • KMID: 1863281
  • Korean J Clin Pathol.
  • 1998 Mar;18(1):1-6.
BACKGROUND: To diagnose paroxysmal nocturnal hemoglobinuria (PNH), the conventional methods such as sucrose lysis test and Ham's test have been used. But their sensitivities were so low that it has...
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