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The History of Myasthenia Gravis

Park JW

  • KMID: 2185023
  • J Korean Neurol Assoc.
  • 2009 May;27(2):98-104.
Since Willis described 'fatigable weakness' in 1672, most physicians consider it as a kind of hysteria due to the inconsistent fluctuation of symptoms. Erb presented three cases of 'bulbal palsy'...
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Evaluation of Presynaptic Action of Depolarizing Neuromuscular Blocking Agents with Single Twitch Response in Vitro

Hwang KH, Chai WS, Kang KS, Kim YI, Park W, Kim SY

BACKGROUND: This study was performed to evaluate the presynaptic effects of depolarizing neuromuscular blocking drugs by using slow and fast frequencies of indirect stimulation on partial twitch depression in vitro. METHODS:...
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Studies of Interaction between Hexamethonium and Lidocaine, alpha-Bungarotoxin or Decamethonium in Vitro

Lee JS, Jeon DG, Kim SY, Choi SJ

BACKGROUND: Interactions of neuromuscular blocking agents are antagonistic in a combination of depolarizing and nondepolarizing agents, additive in a combination of relative two compounds or synergistic in a combination of...
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The Effect of Frequency of Stimulation on Partial Twitch Depression in a Rat Phrenic Nerve Hemidiaphragm Preparation

Lim KI, Hwang KH, Jeong WT, Lee JS, Park W, Kim SY

Background: This study was designed to determine whether presynaptic receptor blockade could be differentiated from postsynaptic receptor blockade by examining the effect of increasing frequencies of indirect stimulation on partial...
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Neuromuscular Blocking Properties of alpha-Bungarotoxin, Decamethonium and Lidocaine in the Rat Phrenic Nerve-Hemidiaphragm Preparation

Kim SY, Kang KS, Kim SC, Lee JS, Cho SH, Kim SI, Kim YI

BACKGROUND: alpha-Bungarotoxin, decamethonium or lidocaine has a neuromuscular blocking effect. The aim of this study was to evaluate the pharmacodynamic properties of these drugs at the neuromuscular junction and...
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Neuromuscular Blocking Properties of beta-Bungarotoxin, Hexamethonium and Verapamil in the Rat Phrenic Nerve-Hemidiaphragm Preparation

Kim SY, Lee JS, Kim SC, Kim SH, Kim YI, Kim SI

BACKGROUND: beta-Bungarotoxin irreversibly changes the presynaptic membrane, hexamethonium acts on the presynaptic nicotinic receptor, and verapamil blocks the ion channels on the presynaptic membrane. The effect of these drugs...
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The Effect of Alcohol in the Nicotinic Acetylcholine Receptor

Min S, Kong ID, Cha SK, Shin J

  • KMID: 2287265
  • Korean J Psychopharmacol.
  • 2006 Jan;17(1):81-90.
OBJECTIVE: It has been well known that alcohol can modulate several ligand-gated ion channel and voltage-gated ion channels. But the roles of alcohol in the autonomic neurons still remain unclear....
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