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Protective efficacy of attenuated Salmonella Typhimurium strain expressing BLS, Omp19, PrpA, or SOD of Brucella abortus in goats

Leya M, Kim WK, Ochirkhuyag E, Yu EC, Kim YJ, Yeo Y, Yang MS, Han SS, Lee JH, Tark D, Hur J, Kim B

Background: Attenuated Salmonella strain can be used as a vector to transport immunogens to the host antigen-binding sites. Objectives: The study aimed to determine the protective efficacy of attenuated Salmonella strain expressing...
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Neglected paths of transmission of milkborne brucellosis and tuberculosis in developing countries: novel control opportunities

Milton AAP, Das S, Ghatak S

Brucellosis and tuberculosis are lingering zoonotic infections that are endemic in many developing parts of the world, with considerable economic and health costs. Although guidelines for the control of these...
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How to improve the human brucellosis surveillance system in Kurdistan Province, Iran: reduce the delay in the diagnosis time

Olfatifar M, Hosseini SM, Shokri P, Khodakarim S, Khadembashi N, Rahimi Pordanjani S

OBJECTIVES: Spatial information makes a crucial contribution to enhancing and monitoring the brucellosis surveillance system by facilitating the timely diagnosis and treatment of brucellosis. METHODS: An exponential scan statistic model was...
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A Case Report of Human Brucellosis Found by Zoonoses Surveillance System Based on One Health

Kim DS, Park SJ, Lee K

Brucellosis is one of the zoonoses, and it is a disease that is almost eliminated in South Korea. This disease is also known as a representative disease of one health....
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Membranoproliferative glomerulonephritis in a patient with chronic brucellosis

Provatopoulou S, Papasotiriou M, Papachristou E, Gakiopoulou H, Marangos M, Goumenos D

Brucellosis is the most common zoonotic disease in Greece, with an endemic distribution and can affect any organ. Infiltration of the renal parenchyma causes acute and chronic interstitial nephritis with...
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Prevalence state of canine brucellosis in South Korea during 2015 and 2016

Jung JY, Yoon SS, Lee SH, Park JW, Lee JJ, Her M, So B, Kim JH

We investigated the prevalence of canine brucellosis in companion and stray dogs between March 2015 and December 2016 and determined the disease characteristics based on the geographic distribution, sex and...
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Best Practice for Prolonged Fever in Primary Care Setting: Close Follow-Up or Empiric Antibiotic Therapy?

Sandoughi , Fazeli SA, Naseri-Ramroudi F, Barzkar F

The management of prolonged fever in low-socioeconomic-status areas by primary care providers such as general practitioners is challenging. Given the endemic nature of many infectious diseases, physicians typically start empirical...
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Vaccination of goats with a combination Salmonella vector expressing four Brucella antigens (BLS, PrpA, Omp19, and SOD) confers protection against Brucella abortus infection

Leya M, Kim WK, Cho JS, Yu EC, Kim YJ, Yeo Y, Lyoo KS, Yang MS, Han SS, Lee JH, Tark D, Hur J, Kim B

Salmonella is an intracellular pathogen with a cellular infection mechanism similar to that of Brucella, making it a suitable choice for use in an anti-Brucella immune boost system. This study...
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An Imported Case of Brucella melitensis Infection in South Korea

Lee JY, Jeon Y, Ahn MY, Ann HW, Jung IY, Jung W, Kim MH, Ahn JY, Song JE, Kim YC, Oh DH, Kim EJ, Jeong SJ, Ku NS, Kim H, Lee K, Kim JM, Choi JY

Brucellosis is a zoonotic infection that is usually transmitted from cattle to humans through ingestion of animal milk, direct contact with animal parts, or inhalation of aerosolized particles. In Korea,...
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Effect of immunization routes and protective efficacy of Brucella antigens delivered via Salmonella vector vaccine

Lalsiamthara J, Won G, Lee JH

An anti-Brucella vaccine candidate comprised of purified Brucella lipopolysaccharide (LPS) and a cocktail of four Salmonella Typhimurium (ST)-Brucella vectors was reported previously. Each vector constitutively expressed highly conserved Brucella antigens...
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Development and trial of vaccines against Brucella

Lalsiamthara J, Lee JH

The search for ideal brucellosis vaccines remains active today. Currently, no licensed human or canine anti-brucellosis vaccines are available. In bovines, the most successful vaccine (S19) is only used in...
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Seroprevalence of Brucellosis in Human Immunodeficiency Virus Infected Patients in Hamadan, Iran

Keramat F, Majzobi MM, Poorolajal J, Ghane ZZ, Adabi M

OBJECTIVES: Brucellosis is a systemic disease with a wide spectrum of clinical manifestations. This study aimed to determine the seroprevalence of brucellosis in human immunodeficiency virus (HIV) infected patients in...
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A Novel PCR Assay for Detecting Brucella abortus and Brucella melitensis

Alamian S, Esmaelizad M, Zahraei T, Etemadi A, Mohammadi , Afshar D, Ghaderi S

OBJECTIVES: Brucellosis is a major zoonotic disease that poses a significant public health threat worldwide. The classical bacteriological detection process used to identify Brucella spp. is difficult and time-consuming. This...
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Diagnostic role of mean platelet volume and neutrophil to lymphocyte ratio in childhood brucellosis

Bozdemir S, Altıntop , Uytun S, Aslaner H, Torun YA

BACKGROUND/AIMS: Brucellosis patients present various non-specific clinical symptoms, such as fever, fatigue, sweating, joint pain, arthritis, myalgia, and headache. Based on the nonspecifity of its clinical signs and symtoms, we...
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Prevalence of bovine tuberculosis, brucellosis and Q fever in Korean black goats

Kim H, Kim S, Kim K, Kim B, Chang B, Choe NH

As the meat of black goats has become popular as a healthy food, domestic goat meat-related industries are steadily growing. However, previous studies are scarce of informations about the zoonotic...
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Review of Brucellosis in Nepal

Acharya KP, Kaphle K, Shrestha K, Garin-Bastuj B, Smits HL

OBJECTIVES: The aim of this paper is to evaluate the current status of the disease, the mechanism of infection, and pathogenesis, its zoonotic potential, diagnostic advances, treatment regimens, and the...
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A Case of Acute Myeloid Leukemia Developing after Treatment for Brucellosis with Pancytopenia

Kim SH, Kim KP, Han S, Kim YR, Kang SH

Human brucellosis is an important zoonotic disease and has a wide clinical spectrum. Nonspecific hematologic abnormalities related to brucellosis are frequently found, but pancytopenia is uncommon. Malignant diseases have been...
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Preparation and Evaluation of a New Lipopolysaccharide-based Conjugate as a Vaccine Candidate for Brucellosis

Siadat SD, Vaziri F, Eftekhary M, Karbasian M, Moshiri A, Aghasadeghi MR, Ardestani MS, Alitappeh MA, Arsang A, Fateh A, Peerayeh SN, Bahrmand AR

Objectives Development of an efficacious vaccine against brucellosis has been a challenge for scientists for many years. At present, there is no licensed vaccine against human brucellosis. To overcome this problem,...
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A Case-Study of Implementation of Improved Strategies for Prevention of Laboratory-acquired Brucellosis

Castrodale LJ, Raczniak G, Rudolph KM, Chikoyak L, Cox RS, Franklin T, Traxler RM, Guerra M

BACKGROUND: In 2012, the Alaska Section of Epidemiology investigated personnel potentially exposed to a Brucella suis isolate as it transited through three laboratories. METHODS: We summarize the first implementation of the...
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Relapsed Brucellosis Presenting as Neurobrucellosis with Cerebral Vasculitis in a Patient Previously Diagnosed with Brucellar Spondylitis: A Case Report

Kim EJ, Lee SJ, Ahn EY, Ryu DG, Choi YH, Kim TH

Brucellosis is a multisystem disease with various clinical symptoms. Neurobrucellosis is a rare but serious manifestation of brucellosis. A 60-year-old man with a previous diagnosis of brucellar spondylitis presented with...
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