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Trial sequential analysis: plain and simple

De Cassai A, Pasin L, Boscolo A, Salvagno M, Navalesi P

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A brief introduction to propensity score for anesthesiologists

De Cassai A, Andreatta G, Boscolo A, Munari M, Navalesi P

Intergroup comparability is of paramount importance in clinical research since it is impossible to draw conclusions on a treatment if populations with different characteristics are compared. While an adequate...
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Explanation of trial sequential analysis: using a post-hoc analysis of meta-analyses published in Korean Journal of Anesthesiology

De Cassai A, Tassone M, Geraldini F, Sergi M, Sella N, Boscolo A, Munari M

Background: Trial sequential analysis (TSA) is a recent cumulative meta-analysis method used to weigh type I and II errors and to estimate when the effect is large enough to be...
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Assignment of ASA-physical status relates to anesthesiologists' experience: a survey-based national-study

De Cassai , Boscolo A, Tonetti T, Ban I, Ori C

BACKGROUND: The American Society of Anesthesiologists physical status (ASA-PS) is a grading system adopted worldwide by anesthesiologists to classify the overall health status of patients. Its importance is demonstrated not...
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Whole-blood hypocoagulable profile correlates with a greater risk of death within 28 days in patients with severe sepsis

Boscolo A, Spiezia L, Campello E, Bertini D, Lucchetta V, Piasentini E, De Cassai A, Simioni P

Background: Hypocoagulability and impaired platelet function have been associated with a high risk of death in sepsis. The aim of this cohort study was to determine whether sepsis-induced hypocoagulability and...
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Preoperative dexmedetomidine and intraoperative bradycardia in laparoscopic cholecystectomy: a meta-analysis with trial sequential analysis

De Cassai A, Sella N, Geraldini F, Zarantonello F, Pettenuzzo T, Pasin L, Iuzzolino M, Rossini N, Pesenti E, Zecchino G, Munari M, Navalesi P, Boscolo A

Background: While laparoscopic surgical procedures have various advantages over traditional open techniques, artificial pneumoperitoneum is associated with severe bradycardia and cardiac arrest. Dexmedetomidine, an imidazole derivative that selectively binds to...
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Single-shot regional anesthesia for laparoscopic cholecystectomies: a systematic review and network meta-analysis

De Cassai A, Sella N, Geraldini F, Tulgar S, Ahiskalioglu A, Dost B, Manfrin S, Karapinar YE, Paganini G, Beldagli M, Luoni V, Ordulu BBK, Boscolo A, Navalesi P

Background: Different regional anesthesia (RA) techniques have been used for laparoscopic cholecystectomy (LC), but there is no consensus on their comparative effectiveness. Our objective was to evaluate the effect of...
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