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Diagnosis and management of monoclonal gammopathy of clinical significance

Cho H

The term “monoclonal gammopathy of clinical significance” (MGCS) refers to any plasma cell or B-cell clonal disorder that does not meet the current criteria for malignant disorders but produces a...
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Diagnostic workup of inherited platelet disorders

Kim B

Inherited platelet disorders (IPDs) can cause mucocutaneous bleeding due to impaired primary hemostatic function of platelets, thrombocytopenia, or both. Recent advances in molecular technology can help identify many genes related...
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Overview of inherited bone marrow failure syndromes

Park M

Patients with inherited bone marrow failure syndrome (IBMFS) can develop peripheral blood cytopenia, which can ultimately progress to myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Although some cases of...
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Treatment of indolent lymphoma

Jeong SH

Treatment of indolent lymphoma has improved significantly in recent decades since the advent of rituximab (anti-CD20 monoclonal antibody). Although, some patients with limited disease can be cured with radiation therapy...
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Update on primary plasma cell leukemia

Jung SH, Lee JJ

Plasma cell leukemia (PCL) is a rare and highly aggressive plasma cell neoplasm developing in 0.5‒4% of patients with multiple myeloma (MM). The diagnostic criteria were recently revised from 20%...
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Staging and response assessment of lymphoma: a brief review of the Lugano classification and the role of FDG-PET/CT

Yoo KH

The accurate assessment of initial disease status and therapeutic responses is critical to the optimal management of patients with lymphoma. Currently, staging and treatment response evaluation for lymphoma has been...
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Diagnosis and management of thrombocytopenia in pregnancy

Park YH

Thrombocytopenia, defined as platelet count <150×10 9 /L, is frequently observed by physicians during pregnancy, with an incidence of approximately 10% of all pregnancies. Most of the cases of thrombocytopenia in...
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Challenging issues in the management of cancer-associated venous thromboembolism

Yhim HY

Venous thromboembolism (VTE) is a common complication among patients with cancer and is associated with delays in underlying cancer treatment and increases in morbidity and mortality. Acute and long-term treatments...
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Evaluation and management of platelet transfusion refractoriness

Youk HJ, Hwang SH, Oh HB, Ko DH

Platelet transfusion refractoriness (PTR), in which platelet counts do not increase after transfusion, occurs in many patients receiving platelet transfusions. PTR is a clinical condition that can harm patients. The...
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FLT3 mutations in acute myeloid leukemia: a review focusing on clinically applicable drugs

Ahn JS, Kim HJ

FMS-like tyrosine kinase 3 (FLT3) mutations, the most frequently detected genetic aberrations in patients with acute myeloid leukemia (AML), are identified in approximately 30% of patients with newly diagnosed AML...
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Recent advances in treatments of adult immune thrombocytopenia

Kim DS

Immune thrombocytopenia (ITP) is isolated thrombocytopenia characterized by autoimmune-mediated disruption of platelet without other etiologies. Treatments for chronic ITP consist of corticosteroids, intravenous immunoglobulins, anti-D immunoglobulin, rituximab, thrombopoietin receptor agonists,...
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Update on the POEMS syndrome

Kim YR

POEMS syndrome is an acronym for polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. It is a rare paraneoplastic disorder related to plasma cell neoplasm. However, its pathophysiology has not...
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Advances in prophylaxis and treatment of invasive fungal infections: perspectives on hematologic diseases

Ahn H, Lee R, Cho SY, Lee DG

Invasive fungal infections (IFIs) are common causes of mortality and morbidity in patients with hematologic diseases. Delayed initiation of antifungal treatment is related to mortality. Aspergillus sp. is the leading...
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Genetics and genomics of bone marrow failure syndrome

Kim HY, Kim HJ, Kim SH

Inherited bone marrow failure syndrome (IBMFS) is a group of clinically heterogeneous disorders characterized by significant hematological cytopenias of one or more hematopoietic cell lineages and is associated with an...
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Advances in laboratory assessment of thrombosis and hemostasis

Song J

Technologies in laboratory diagnostics are changing fast with progress in understanding and therapy of diseases. Unfortunately, new analyzers are often needed to be installed in a clinical laboratory to implement...
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Basic immunohistochemistry for lymphoma diagnosis

Cho J

Immunohistochemistry is a technique that uses antigen-antibody interactions to detect specific proteins in cells. This technique has several essential applications in lymphoma diagnosis, including identifying the cell lineage and phase...
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Human acute myeloid leukemia stem cells: evolution of concept

Shin DY

The history of human acute myeloid leukemia stem cells (AMLSCs) began in a seminal study performed by Lapidot and Dick, proving that only CD34+CD38- human primary acute myeloid leukemia (AML)...
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Recent advances in the management of immune-mediated thrombotic thrombocytopenic purpura

Bae SH, Kim SH, Bang SM

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a potentially life-threatening thrombotic microangiopathy caused by autoantibody-mediated severe ADAMTS13 deficiency. TTP should be suspected in patients with microangiopathic hemolytic anemia and thrombocytopenia without...
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Assessing frailty using comprehensive geriatric assessment in older patients with hematologic malignancy

Choi JY, Kim Ki

The incidence of hematologic malignancy increases with age; thus, the number of older patients who require intensive chemotherapy is expected to increase with the aging population. In Korea, 61.8%, 59.3%,...
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