- Myelodysplastic syndrome with genetic predisposition
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Park M
- KMID: 2515296
- Blood Res.
- 2021 Apr;56(S1):S34-S38.
- doi: 10.5045/br.2021.2020327
Myelodysplastic syndrome (MDS) refers to a heterogeneous group of clonal blood disorders characterized by ineffective hematopoiesis, cytopenia, dysplasia, and an increased risk of acute myeloid leukemia (AML). A growing number... -
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- Molecular basis and diagnosis of thalassemia
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Lee JS, Cho SI, Park SS, Seong MW
- KMID: 2515297
- Blood Res.
- 2021 Apr;56(S1):S39-S43.
- doi: 10.5045/br.2021.2020332
Thalassemia is characterized by the impaired synthesis of globin chains due to disease-causing variants in α- or β-globin genes. In this review, we provide an overview of the molecular basis... -
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- Novel combination immunochemotherapy beyond CD20 for B-cell lymphomas
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Yi JH
- KMID: 2515292
- Blood Res.
- 2021 Apr;56(S1):S1-S4.
- doi: 10.5045/br.2021.2020320
Despite substantially improved survival with rituximab-based treatment regimens, there is an unmet medical need for better treatments of B-cell lymphoma, particularly for patients with relapsed or refractory disease. Retreatment with... -
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- Genomics of diffuse large B cell lymphoma
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Koh Y
- KMID: 2515302
- Blood Res.
- 2021 Apr;56(S1):S75-S79.
- doi: 10.5045/br.2021.2021049
Next generation sequencing (NGS) technology has revealed the heterogeneity of diffuse large B-cell lymphoma (DLBCL) from a mutation perspective. Accordingly, the conventional cell of origin-based classification of DLBCL has changed... -
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- Diagnosis and treatment of chronic myelomonocytic leukemia
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Kwon J
- KMID: 2515293
- Blood Res.
- 2021 Apr;56(S1):S5-S16.
- doi: 10.5045/br.2021.2020321
Chronic myelomonocytic leukemia (CMML) is a clonal disorder of hematopoietic cells and is a complex of heterogeneous conditions with both myeloproliferative and myelodysplastic features. The diagnosis of CMML is made... -
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- Myelodysplastic syndromes and overlap syndromes
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Chang YH
- KMID: 2515299
- Blood Res.
- 2021 Apr;56(S1):S51-S64.
- doi: 10.5045/br.2021.2021010
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematological neoplasms characterized by ineffective hematopoiesis, morphologic dysplasia, and cytopenia. MDS overlap syndromes include various disorders, such as myelodysplastic/myeloproliferative neoplasms and... -
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- Immuno-oncology for B-cell lymphomas
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Choi YS
- KMID: 2515301
- Blood Res.
- 2021 Apr;56(S1):S70-S74.
- doi: 10.5045/br.2021.2021032
The goal of cancer immunotherapy is to restore and optimize the immune response against malignant clones through several stages, from recognition of tumor antigens to establishment of long-lived memory cell... -
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- Current status of the diagnosis and treatment of hemophagocytic lymphohistiocytosis in adults
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Kim YR, Kim DY
- KMID: 2515294
- Blood Res.
- 2021 Apr;56(S1):S17-S25.
- doi: 10.5045/br.2021.2020323
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of defective apoptosis, a disruption of the regulatory pathway that terminates immune and inflammatory responses. Fever, cytopenia, splenomegaly, and/or hemophagocytosis are typical findings of this... -
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- The clinical role of interferon alpha in Philadelphia-negative myeloproliferative neoplasms
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Yoon SY, Won JH
- KMID: 2515298
- Blood Res.
- 2021 Apr;56(S1):S44-S50.
- doi: 10.5045/br.2021.2020334
Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell malignancies. Chronic inflammation and a dysregulated immune system are central to the pathogenesis and progression of MPNs. Interferon alpha (IFNα) was first used... -
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- Recent advances in the understanding of the molecular pathogenesis and targeted therapy options in Langerhans cell histiocytosis
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- KMID: 2515300
- Blood Res.
- 2021 Apr;56(S1):S65-S69.
- doi: 10.5045/br.2021.2021013
Langerhans cell histiocytosis (LCH) is the most common histiocytic disorder caused by the clonal expansion of myeloid precursors that differentiate into CD1a+/CD207+ cells in the lesion. Advances in genomic sequencing... -
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- Disease modifying agents of myeloproliferative neoplasms: a review
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Lee SE
- KMID: 2515295
- Blood Res.
- 2021 Apr;56(S1):S26-S33.
- doi: 10.5045/br.2021.2020325
The identification of driver mutations in Janus kinase (JAK ) 2, calreticulin (CALR), and myeloproliferative leukemia (MPL) has contributed to a better understanding of disease pathogenesis by highlighting the importance... -
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