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The proteomic landscape shows oncologic relevance in cystitis glandularis

Kim JY, Han D, Kim H, Jung M, Ryu HS

Background: The relationship between cystitis glandularis (CG) and bladder malignancy remains unclear. Methods: We identified the oncologic significance of CG at the molecular level using liquid chromatography-tandem mass spectrometry-based proteomic...
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Silver Nanoparticles Exert Apoptotic Activity in Bladder Cancer 5637 Cells Through Alteration of Bax/Bcl-2 Genes Expression

Daei S, Ziamajidi N, Abbasalipourkabir R, Aminzadeh Z, Vahabirad M

Bladder cancer is defined as a urinary tract malignancy that threatens men’s and women’s health. Due to the side effects of common chemotherapies, novel therapeutic strategies are necessary to overcome...
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Laparoscopic radical cystectomy with pelvic lymph node dissection and ileal orthotopic neobladder by a total extraperitoneal approach: Our initial technique and short-term outcomes

Zhu G, Zhang Z, Zhao K, Yin X, Zhang Y, Wang Z, Li C, Sui Y, Li X, Yang H, Xing N, Wang K

Purpose: With the increasing application of laparoscopic or robot-assisted radical cystectomy, a reliable and promising method is needed for reducing postoperative complications. We describe the short-term outcomes of totally extraperitoneal...
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External validation of European Association of Urology NMIBC risk scores to predict progression after transurethral resection of bladder tumor in Korean patients with non-muscle-invasive bladder cancer

Kim JY, Lee DB, Song WH, Lee SS, Park SW, Nam JK

Purpose: This study aimed to validate the newly proposed risk model in Korean patients diagnosed with non-muscle-invasive bladder cancer (NMIBC). Materials and Methods: A retrospective review was performed with 1,238 patients...
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A novel strategy for treatment of bladder cancer: Antibody-drug conjugates

Kim JH, Chang IH

In the past, there was no second-line chemotherapeutic agent suitable for use when urothelial carcinoma (UC) progressed to platinum-resistant UC. However, recently, several new treatment options, such as immune checkpoint...
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Genomic Sequencing for Bladder Urothelial Carcinoma and Its Clinical Implications for Immunotherapy

Kim R, Hong JY, Lee J, Kwon GY, Jeong BC, Park SH

Purpose This study aimed to explore the genomic and transcriptomic landscape of bladder cancer (BC) and its implication for treatment with an immune checkpoint inhibitor (ICI). Materials and Methods We analyzed...
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Next-generation Proteomics-Based Discovery, Verification, and Validation of Urine Biomarkers for Bladder Cancer Diagnosis

Suh J, Han D, Ku JH, Kim HH, Kwak C, Jeong CW

Purpose We aimed to identify, verify, and validate a multiplex urinary biomarker-based prediction model for diagnosis and surveillance of urothelial carcinoma of bladder, using high-throughput proteomics methods. Materials and Methods Label-free quantification...
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Bladder Cancer Metastasis to the Breast in a Male Patient: Imaging Findings on Mammography and Ultrasonography

Yoon IN, Cha ES, Kim JH, Lee JE, Chung J

Male breast cancer is rare, accounting for approximately 1% of breast cancers. Metastasis from extra-mammary malignancy to the breast in men is extremely rare. The most common primary tumors that...
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Upper Gastrointestinal Bleeding with Cholecystoduodenal Fistula

Seo MW

Cholecystoduodenal fistula, caused by gallbladder stone, trauma, peptic ulcer disease, and malignancy, is an uncommon cause of upper gastrointestinal hemorrhage. I report a case of cholecystoduodenal fistula with upper gastrointestinal...
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Low-dose versus standard-dose bacille Calmette–Guérin for non-muscle-invasive bladder cancer: Systematic review and meta-analysis of randomized controlled trials

Choi SY, Ha MS, Kim JH, Chi BH, Kim JW, Chang IH, Kim TH, Myung SC

Purpose: Intravesical BCG (bacille Calmette–Guérin) instillation in patients with non-muscle-invasive bladder cancer decreases the risk for tumor recurrence and progression. After one BCG product was discontinued, a chronic global BCG...
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Clinical Significance of Rab27a as a Urinary Biomarker in Patients With Bladder Cancer

Ku JY, Hwang EC, Lee CH, Kim KH, Kwon DD, Ha HK

Purpose: The aims of this study were to investigate the clinical value of Rab27a as a urinary biomarker, and its efficiency in the prediction of bladder cancer grade. Materials and Methods:...
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De Ritis Ratio, Neutrophil-to-Lymphocyte Ratio, and Albumin Are Significant Prognostic Factors for Survival Even After Adjusted by the Treatment Duration in Metastatic Kidney and Bladder Cancer Treated With Immune-Checkpoint Inhibitors

Kim SH, Park EY, Lee HH, Chung J, Seo HK

Purpose: This study aimed to determine the prognostic roles of several immune-related laboratory parameters in patients with metastatic kidney and bladder cancer treated with immune checkpoint inhibitors (ICIs). Materials and Methods:...
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New Drugs for Bacillus Calmette Guérin-Unresponsive Nonmuscle Invasive Bladder Cancer

Jeong J, Ha JB, Chang IH

For intermediate- and high-risk nonmuscle invasive bladder cancer (NMIBC), intravesical Bacillus Calmette-Guérin (BCG) therapy is the standard adjuvant treatment following transurethral resection of bladder tumor. Although intravesical BCG therapy improves...
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Gender-related outcomes in robot-assisted radical cystectomy: A multi-institutional study

Jin HJ, Shim JS, Kwon TG, Kim TH, Jeon SH, Lee SH, Kang SG, Nam JK, Kim WS, Jeong BC, Oh JJ, Lee SC, Lee JY, Hong SH, Rha KH, Han WK, Ham WS, Lee YG, Lee YS, Park SY, Yoon YE, Ku JH, Kang SH

Purpose: Robot-assisted radical cystectomy (RARC) optimizes patient recovery and has outcomes comparable with those of open surgery. This study aimed to compare the perioperative and oncologic outcomes of RARC in...
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Presence and predominance of histological grade 3 define cT1HG bladder cancer prognostic groups

Reis LO, Col LSBD, Capibaribe DM, Mendonça GBd, Denardi F, Billis A

Purpose: Current World Health Organization/International Society of Urological Pathology (2004 WHO/ISUP) grading of bladder urothelial carcinoma relies on the highest pathologic grade of the specimen and does not reflect the...
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Evaluating the efficacy of secondary transurethral resection of the bladder for high-grade Ta tumors

Lee K, Jeong Sh, Yoo SH, Ku JH

Purpose: The need for secondary transurethral resection of the bladder (re-TURB) in patients with high-grade Ta tumors has not been assessed. This study aimed to compare the outcomes of patients...
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The Prognosis and the Role of Adjuvant Chemotherapy for Node-Positive Bladder Cancer Treated with Neoadjuvant Chemotherapy Followed by Surgery

Jeong H, Park KJ, Lee Y, Kim HD, Kim JH, Yoon S, Hong B, Lee JL

Purpose This study aims to evaluate the prognosis of pathologically node-positive bladder cancer after neoadjuvant chemotherapy, the role of adjuvant chemotherapy in these patients, and the value of preoperative clinical...
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Perioperative Outcomes of Different Surgical Methods Among Bladder Cancer Patients Undergoing Radical Cystectomy With Neobladder Urinary Diversion

Kim HJ, Ye C, Kim JH, Kim H, Lee S, Byun SS, Oh JJ

Purpose: To compare perioperative outcomes according to surgical methods among bladder cancer patients who underwent radical cystectomy (RC) with neobladder urinary diversion. Materials and Methods: Between June 2007 and January 2020,...
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Intravesical gemcitabine for non-muscle invasive bladder cancer: An abridged Cochrane Review

Han MA, Maisch P, Jung JH, Hwang JE, Narayan V, Cleves A, Hwang EC, Dahm P

Purpose: To assess the comparative effectiveness and toxicity of intravesical gemcitabine instillation for non-muscle invasive bladder cancer (NMIBC). Materials and Methods: We performed a comprehensive literature search on 11 September 2020....
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Epstein-Barr Virus-associated Mixed Lymphoepithelioma-like Carcinoma and Adenocarcinoma of the Gall Bladder: An Unusual Entity

Jain N, Goyal S, Sakhuja P, Saluja S

Schmincke described lymphoepithelioma as an undifferentiated carcinoma with abundant lymphoid stroma in the nasopharynx. Tumors with a similar histomorphology in extrapharyngeal areas have been referred to as lymphoepithelioma-like carcinoma (LELC)....
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