- Tumour Regression via Integrative Regulation of Neurological, Inflammatory, and Hypoxic Tumour Microenvironment
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Lee CH, Cho J, Lee K
- KMID: 2507842
- Biomol Ther.
- 2020 Mar;28(2):119-130.
- doi: 10.4062/biomolther.2019.135
Changing trends in anticancer research have altered the treatment paradigm to the extent that it is difficult to investigate any anticancer drugs without mentioning immunotherapy. Thus, we are finally contemplating... -
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- Erratum to "Decursinol Angelate Ameliorates Dextran Sodium Sulfate-Induced Colitis by Modulating Type 17 Helper T Cell Responses"
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Thapa B, Pak S, Kwon HJ, Lee K
- KMID: 2507832
- Biomol Ther.
- 2020 Mar;28(2):211-211.
- doi: 10.4062/biomolther.2019.221
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- Spinosin Attenuates Alzheimer’s Disease-Associated Synaptic Dysfunction via Regulation of Plasmin Activity
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Cai M, Jung I, Kwon H, Cho E, Jeon J, Yun J, Lee YC, Kim DH, Ryu JH
- KMID: 2507841
- Biomol Ther.
- 2020 Mar;28(2):131-136.
- doi: 10.4062/biomolther.2019.076
Hippocampal synaptic dysfunction is a hallmark of Alzheimer’s disease (AD). Many agents regulating hippocampal synaptic plasticity show an ameliorative effect on AD pathology, making them potential candidates for AD therapy.... -
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- PBT-6, a Novel PI3KC2γ Inhibitor in Rheumatoid Arthritis
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Kim J, Jung KH, Yoo J, Park JH, Yan HH, Fang Z, Lim JH, Kwon SR, Kim MK, Park HJ, Hong SS
- KMID: 2507836
- Biomol Ther.
- 2020 Mar;28(2):172-183.
- doi: 10.4062/biomolther.2019.153
Phosphoinositide 3-kinase (PI3K) is considered as a promising therapeutic target for rheumatoid arthritis (RA) because of its involvement in inflammatory processes. However, limited studies have reported the involvement of PI3KC2γ... -
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- Functional Expression of Choline Transporter-Like Protein 1 in LNCaP Prostate Cancer Cells: A Novel Molecular Target
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Saiki I, Yara M, Yamanaka T, Uchino H, Inazu M
- KMID: 2507834
- Biomol Ther.
- 2020 Mar;28(2):195-201.
- doi: 10.4062/biomolther.2019.097
Prostate cancer is one of the most common cancers in men. Choline PET or PET/CT has been used to visualize prostate cancer, and high levels of choline accumulation have been... -
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- Polyphenolic Biflavonoids Inhibit Amyloid-Beta Fibrillation and Disaggregate Preformed Amyloid-Beta Fibrils
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Choi EY, Kang SS, Lee SK, Han BH
- KMID: 2507839
- Biomol Ther.
- 2020 Mar;28(2):145-151.
- doi: 10.4062/biomolther.2019.113
Alzheimer’s disease (AD) is a devastating neurodegenerative disease and a major cause of dementia in elderly individuals world-wide. Increased deposition of insoluble amyloid β (Aβ) fibrils in the brain is... -
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- Fluoxetine Simultaneously Induces Both Apoptosis and Autophagy in Human Gastric Adenocarcinoma Cells
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Po WW, Thein W, Khin PP, Khing TM, Han KWW, Park CH, Sohn UD
- KMID: 2507833
- Biomol Ther.
- 2020 Mar;28(2):202-210.
- doi: 10.4062/biomolther.2019.103
Fluoxetine is used widely as an antidepressant for the treatment of cancer-related depression, but has been reported to also have anti-cancer activity. In this study, we investigated the cytotoxicity of... -
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- Involvement of Estrogen Receptor-α in the Activation of Nrf2-Antioxidative Signaling Pathways by Silibinin in Pancreatic β-Cells
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Chu C, Gao X, Li X, Zhang X, Ma R, Jia Y, Li D, Wang D, Xu F
- KMID: 2507837
- Biomol Ther.
- 2020 Mar;28(2):163-171.
- doi: 10.4062/biomolther.2019.071
Silibinin exhibits antidiabetic potential by preserving the mass and function of pancreatic β-cells through up-regulation of estrogen receptor-α (ERα) expression. However, the underlying protective mechanism of silibinin in pancreatic β-cells... -
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- PEGylated Erythropoietin Protects against Brain Injury in the MCAO-Induced Stroke Model by Blocking NF-κB Activation
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Im JH, Yeo IJ, Hwang CJ, Lee KS, Hong JT
- KMID: 2507838
- Biomol Ther.
- 2020 Mar;28(2):152-162.
- doi: 10.4062/biomolther.2019.147
Cerebral ischemia exhibits a multiplicity of pathophysiological mechanisms. During ischemic stroke, the reactive oxygen species (ROS) concentration rises to a peak during reperfusion, possibly underlying neuronal death. Recombinant human erythropoietin... -
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- A New Histone Deacetylase Inhibitor, MHY4381, Induces Apoptosis via Generation of Reactive Oxygen Species in Human Prostate Cancer Cells
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Richa S, Dey P, Park C, Yang J, Son JY, Park JH, Lee SH, Ahn MY, Kim IS, Moon HR, Kim HS
- KMID: 2507835
- Biomol Ther.
- 2020 Mar;28(2):184-194.
- doi: 10.4062/biomolther.2019.074
Histone deacetylase (HDAC) inhibitors represent a novel class of anticancer agents, which can be used to inhibit cell proliferation and induce apoptosis in several types of cancer cells. In this... -
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- Catalpol and Mannitol, Two Components of Rehmannia glutinosa, Exhibit Anticonvulsant Effects Probably via GABA A Receptor Regulation
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Kim M, Acharya S, Botanas CJ, Custodio RJ, Lee HJ, Sayson LV, Abiero A, Lee YS, Cheong JH, Kim Km, Kim HJ
- KMID: 2507840
- Biomol Ther.
- 2020 Mar;28(2):137-144.
- doi: 10.4062/biomolther.2019.130
Epilepsy is a brain disorder that affects millions of people worldwide and is usually managed using currently available antiepileptic drugs, which result in adverse effects and are ineffective in approximately... -
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