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G0/G1 Switch 2 Induces Cell Survival and Metastasis through Integrin-Mediated Signal Transduction in Human Invasive Breast Cancer Cells

Cho E, Kwon YJ, Ye DJ, Baek HS, Kwon TU, Choi HK, Chun YJ

  • Biomol Ther.
  • 2019 Nov;27(6):591-602.
  • doi: 10.4062/biomolther.2019.063
Human breast cancer cell line, MDA-MB-231, is highly invasive and aggressive, compared to less invasive cell line, MCF-7. To explore the genes that might influence the malignancy of MDA-MB-231, DNA...
Sleep Promoting Effect of Luteolin in Mice via Adenosine A1 and A2A Receptors

Kim TH, Custodio R, Cheong JH, Kim HJ, Jung YS

  • Biomol Ther.
  • 2019 Nov;27(6):584-590.
  • doi: 10.4062/biomolther.2019.149
Luteolin, a widespread flavonoid, has been known to have neuroprotective activity against various neurologic diseases such as epilepsy, and Alzheimer’s disease. However, little information is available regarding the hypnotic effect...
Functional Characterization of Pharmcogenetic Variants of Human Cytochrome P450 2C9 in Korean Populations

Cho MA, Yoon JG, Kim V, Kim H, Lee R, Lee MG, Kim D

  • Biomol Ther.
  • 2019 Nov;27(6):577-583.
  • doi: 10.4062/biomolther.2019.112
Human cytochrome P450 2C9 is a highly polymorphic enzyme that is required for drug and xenobiotic metabolism. Here, we studied eleven P450 2C9 genetic variants—including three novel variants F69S, L310V,...
Particulate Matter-Induced Aryl Hydrocarbon Receptor Regulates Autophagy in Keratinocytes

Jang HS, Lee JE, Myung CH, Park JI, Jo CS, Hwang JS

  • Biomol Ther.
  • 2019 Nov;27(6):570-576.
  • doi: 10.4062/biomolther.2019.025
Particulate matter (PM), which refers to the mixture of particles present in the air, can have harmful effects. Damage to cells by PM, including disruption of organelles and proteins, can...
Niacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter

Zhen AX, Piao MJ, Kang KA, Madushan Fernando PDS, Kang HK, Koh YS, Yi JM, Hyun JW

  • Biomol Ther.
  • 2019 Nov;27(6):562-569.
  • doi: 10.4062/biomolther.2019.061
Niacinamide (NIA) is a water-soluble vitamin that is widely used in the treatment of skin diseases. Moreover, NIA displays antioxidant effects and helps repair damaged DNA. Recent studies showed that...
Rab25 Deficiency Perturbs Epidermal Differentiation and Skin Barrier Function in Mice

Jeong H, Lim KM, Goldenring JR, Nam KT

  • Biomol Ther.
  • 2019 Nov;27(6):553-561.
  • doi: 10.4062/biomolther.2019.125
Rab25, a member of the Rab11 small GTPase family, is central to achieving cellular polarity in epithelial tissues. Rab25 is highly expressed in epithelial cells of various tissues including breast,...
Alyssin and Iberin in Cruciferous Vegetables Exert Anticancer Activity in HepG2 by Increasing Intracellular Reactive Oxygen Species and Tubulin Depolymerization

Pocasap P, Weerapreeyakul N, Thumanu K

  • Biomol Ther.
  • 2019 Nov;27(6):540-552.
  • doi: 10.4062/biomolther.2019.027
To determine the chemopreventive potential of alyssin and iberin, the in vitro anticancer activities and molecular targets of isothiocyanates (ITCs) were measured and compared to sulforaphane in hepatocellular carcinoma cell...
Etoposide Induces Mitochondrial Dysfunction and Cellular Senescence in Primary Cultured Rat Astrocytes

Bang M, Kim DG, Gonzales E, Kwon KJ, Shin CY

  • Biomol Ther.
  • 2019 Nov;27(6):530-539.
  • doi: 10.4062/biomolther.2019.151
Brain aging is an inevitable process characterized by structural and functional changes and is a major risk factor for neurodegenerative diseases. Most brain aging studies are focused on neurons and...
S1P₁ Regulates M1/M2 Polarization toward Brain Injury after Transient Focal Cerebral Ischemia

Gaire BP, Bae YJ, Choi JW

  • Biomol Ther.
  • 2019 Nov;27(6):522-529.
  • doi: 10.4062/biomolther.2019.005
M1/M2 polarization of immune cells including microglia has been well characterized. It mediates detrimental or beneficial roles in neuroinflammatory disorders including cerebral ischemia. We have previously found that sphingosine 1-phospate...
Role of Helix 8 in Dopamine Receptor Signaling

Yang HS, Sun N, Zhao X, Kim HR, Park HJ, Kim KM, Chung KY

  • Biomol Ther.
  • 2019 Nov;27(6):514-521.
  • doi: 10.4062/biomolther.2019.026
G protein-coupled receptors (GPCRs) are membrane receptors whose agonist-induced dynamic conformational changes trigger heterotrimeric G protein activation, followed by GRK-mediated phosphorylation and arrestin-mediated desensitization. Cytosolic regions of GPCRs have been...
Natural Products as Sources of Novel Drug Candidates for the Pharmacological Management of Osteoarthritis: A Narrative Review

Kang YH, Lee HJ, Lee CJ, Park JS

  • Biomol Ther.
  • 2019 Nov;27(6):503-513.
  • doi: 10.4062/biomolther.2019.139
Osteoarthritis is a chronic degenerative articular disorder. Formation of bone spurs, synovial inflammation, loss of cartilage, and underlying bone restructuring have been reported to be the main pathologic characteristics of...

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