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16 results

Erratum to “Protective Effects of Ecklonia stolonifera Extract on Ethanol-Induced Fatty Liver in Rats” [Biomol.Ther. 24 (2016) 650–658]

Bang CY, Byun JH, Choi HK, Choi JS, Choung SY

  • Biomol Ther.
  • 2017 Mar;25(2):222-222.
  • doi: 10.4062/biomolther.2017.222
No abstract available.
Baicalein Inhibits the Migration and Invasion of B16F10 Mouse Melanoma Cells through Inactivation of the PI3K/Akt Signaling Pathway

Choi EO, Cho EJ, Jeong JW, Park C, Hong SH, Hwang HJ, Moon SK, Son CG, Kim WJ, Choi YH

  • Biomol Ther.
  • 2017 Mar;25(2):213-221.
  • doi: 10.4062/biomolther.2016.094
Baicalein, a natural flavonoid obtained from the rhizome of Scutellaria baicalensis Georgi, has been reported to have anticancer activities in several human cancer cell lines. However, its antimetastatic effects and...
Ginsenoside Rb1 Inhibits Doxorubicin-Triggered H9C2 Cell Apoptosis via Aryl Hydrocarbon Receptor

Zhang Y, Wang Y, Ma Z, Liang Q, Tang X, Tan H, Xiao C, Gao Y

  • Biomol Ther.
  • 2017 Mar;25(2):202-212.
  • doi: 10.4062/biomolther.2016.066
Doxorubicin (DOX) is a highly effective chemotherapeutic agent; however, the dose-dependent cardiotoxicity associated with DOX significantly limits its clinical application. In the present study, we investigated whether Rb1 could prevent...
Calcium Signaling of Lysophosphatidylethanolamine through LPA1 in Human SH-SY5Y Neuroblastoma Cells

Lee JM, Park SJ, Im DS

  • Biomol Ther.
  • 2017 Mar;25(2):194-201.
  • doi: 10.4062/biomolther.2016.046
Lysophosphatidylethanolamine (LPE), a lyso-type metabolite of phosphatidylethanolamine, has been reported to be an intercellular signaling molecule. LPE mobilizes intracellular Ca²⁺ through G-protein-coupled receptor (GPCR) in some cells types. However, GPCRs...
Tetrandrine Exerts a Radiosensitization Effect on Human Glioma through Inhibiting Proliferation by Attenuating ERK Phosphorylation

Ma JW, Zhang Y, Ye JC, Li R, Wen YL, Huang JX, Zhong XY

  • Biomol Ther.
  • 2017 Mar;25(2):186-193.
  • doi: 10.4062/biomolther.2016.044
Tetrandrine (Tet), a bisbenzylisoquinoline alkaloid, has been reported to have a radiosensitization effect on tumors. However, its effects on human glioma and the specific molecular mechanisms of these effects remain...
Auranofin Suppresses Plasminogen Activator Inhibitor-2 Expression through Annexin A5 Induction in Human Prostate Cancer Cells

Shin DW, Kwon YJ, Ye DJ, Baek HS, Lee JE, Chun YJ

  • Biomol Ther.
  • 2017 Mar;25(2):177-185.
  • doi: 10.4062/biomolther.2016.223
Auranofin has been developed as antirheumatic drugs, which is currently under clinical development for the treatment of chronic lymphocytic leukemia. Previous report showed that auranofin induced apoptosis by enhancement of...
Characterization of a Biflaviolin Synthase CYP158A3 from Streptomyces avermitilis and Its Role in the Biosynthesis of Secondary Metabolites

Lim YR, Han S, Kim JH, Park HG, Lee GY, Le TK, Yun CH, Kim D

  • Biomol Ther.
  • 2017 Mar;25(2):171-176.
  • doi: 10.4062/biomolther.2016.182
Streptomyces avermitilis produces clinically useful drugs such as avermectins and oligomycins. Its genome contains approximately 33 cytochrome P450 genes and they seem to play important roles in the biosynthesis of...
Chemical Constituents Identified from Fruit Body of Cordyceps bassiana and Their Anti-Inflammatory Activity

Suh W, Nam G, Yang WS, Sung GH, Shim SH, Cho JY

  • Biomol Ther.
  • 2017 Mar;25(2):165-170.
  • doi: 10.4062/biomolther.2016.063
Cordyceps bassiana is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. This mushroom has recently demonstrated to have an ability to reduce 2,4-dinitrofluorobenzene-induced atopic...
Hypericin, a Naphthodianthrone Derivative, Prevents Methylglyoxal-Induced Human Endothelial Cell Dysfunction

Do MH, Kim SY

  • Biomol Ther.
  • 2017 Mar;25(2):158-164.
  • doi: 10.4062/biomolther.2016.034
Methylglyoxal (MGO) is a highly reactive metabolite of glucose which is known to cause damage and induce apoptosis in endothelial cells. Endothelial cell damage is implicated in the progression of...
Intranasal Administration of Interleukin-1 Receptor Antagonist in a Transient Focal Cerebral Ischemia Rat Model

Lee JH, Kam EH, Kim JM, Kim SY, Kim EJ, Cheon SY, Koo BN

  • Biomol Ther.
  • 2017 Mar;25(2):149-157.
  • doi: 10.4062/biomolther.2016.050
The interleukin-1 receptor antagonist (IL-1RA) is a potential stroke treatment candidate. Intranasal delivery is a novel method thereby a therapeutic protein can be penetrated into the brain parenchyma by bypassing...
Restoration of Declined Immune Responses and Hyperlipidemia by Rubus occidenalis in Diet-Induced Obese Mice

Lee Y, Kim J, An J, Lee S, Lee H, Kong H, Song Y, Choi HR, Kwon JW, Shin D, Lee CK, Kim K

  • Biomol Ther.
  • 2017 Mar;25(2):140-148.
  • doi: 10.4062/biomolther.2016.052
Hyperlipidemia, which is closely associated with a fatty diet and aging, is commonly observed in the western and aged society. Therefore, a novel therapeutic approach for this disease is critical,...
Enforced Expression of CXCR5 Drives T Follicular Regulatory-Like Features in Foxp3⁺ T Cells

Kim YU, Kim BS, Lim H, Wetsel RA, Chung Y

  • Biomol Ther.
  • 2017 Mar;25(2):130-139.
  • doi: 10.4062/biomolther.2016.075
CXCR5⁺ T follicular helper (Tfh) cells are associated with aberrant autoantibody production in patients with antibody-mediated autoimmune diseases including lupus. Follicular regulatory T (Tfr) cells expressing CXCR5 and Bcl6 have...
The Abuse Potential of α-Piperidinopropiophenone (PIPP) and α-Piperidinopentiothiophenone (PIVT), Two New Synthetic Cathinones with Piperidine Ring Substituent

Botanas CJ, Yoon SS, de la Peña JB, dela Peña IJ, Kim M, Woo T, Seo JW, Jang CG, Park KT, Lee YH, Lee YS, Kim HJ, Cheong JH

  • Biomol Ther.
  • 2017 Mar;25(2):122-129.
  • doi: 10.4062/biomolther.2016.241
A diversity of synthetic cathinones has flooded the recreational drug marketplace worldwide. This variety is often a response to legal control actions for one specific compound (e.g. methcathinone) which has...
Expression Levels of GABA-A Receptor Subunit Alpha 3, Gabra3 and Lipoprotein Lipase, Lpl Are Associated with the Susceptibility to Acetaminophen-Induced Hepatotoxicity

Kim M, Yun JW, Shin K, Cho Y, Yang M, Nam KT, Lim KM

  • Biomol Ther.
  • 2017 Mar;25(2):112-121.
  • doi: 10.4062/biomolther.2016.076
Drug-induced liver injury (DILI) is the serious and fatal drug-associated adverse effect, but its incidence is very low and individual variation in severity is substantial. Acetaminophen (APAP)-induced liver injury accounts...
Rosmarinic Acid Potentiates Pentobarbital-Induced Sleep Behaviors and Non-Rapid Eye Movement (NREM) Sleep through the Activation of GABA(A)-ergic Systems

Kwon YO, Hong JT, Oh KW

  • Biomol Ther.
  • 2017 Mar;25(2):105-111.
  • doi: 10.4062/biomolther.2016.035
It has been known that RA, one of major constituents of Perilla frutescens which has been used as a traditional folk remedy for sedation in oriental countries, shows the anxiolytic-like...
Therapeutic Potential of Medicinal Plants and Their Constituents on Lung Inflammatory Disorders

Kim HP, Lim H, Kwon YS

  • Biomol Ther.
  • 2017 Mar;25(2):91-104.
  • doi: 10.4062/biomolther.2016.187
Acute bronchitis and chronic obstructive pulmonary diseases (COPD) are essentially lung inflammatory disorders. Various plant extracts and their constituents showed therapeutic effects on several animal models of lung inflammation. These...

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