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15 results

Erratum to “Marine Sponges as a Drug Treasure” [Biomol.Ther. 24 (2016) 347–362]

Anjum K, Abbas SQ, Shah SA, Akhter N, Batool S, Hassan SS

  • Biomol Ther.
  • 2016 Sep;24(5):559-559.
  • doi: 10.4062/biomolther.2016.559
The authors request to correct the title of Table 3.
Inhibitory Effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71

Choi HJ, Song HH, Lee JS, Ko HJ, Song JH

  • Biomol Ther.
  • 2016 Sep;24(5):552-558.
  • doi: 10.4062/biomolther.2015.200
Severe complications associated with EV71 infections are a common cause of neonatal death. Lack of effective therapeutic agents for these infections underlines the importance of research for the development of...
Vaccinium bracteatum Thunb. Exerts Anti-Inflammatory Activity by Inhibiting NF-κB Activation in BV-2 Microglial Cells

Kwon SH, Ma SX, Ko YH, Seo JY, Lee BR, Lee TH, Kim SY, Lee SY, Jang CG

  • Biomol Ther.
  • 2016 Sep;24(5):543-551.
  • doi: 10.4062/biomolther.2015.205
This study was designed to evaluate the pharmacological effects of Vaccinium bracteatum Thunb. methanol extract (VBME) on microglial activation and to identify the underlying mechanisms of action of these effects....
Evaluating Pharmacological Effects of Two Major Components of Shuangdan Oral Liquid: Role of Danshensu and Paeonol in Diabetic Nephropathy Rat

Chen Y, Liu Z, Zhou F, Zhao H, Yang Q, Li H, Sun J, Wang S

  • Biomol Ther.
  • 2016 Sep;24(5):536-542.
  • doi: 10.4062/biomolther.2015.191
Shuangdan oral liquid (SDO) containing radix Salviae miltiorrhizae (Chinese name Danshen) and cortex moutan (Chinese name Mudanpi) is a traditional Chinese medicine using for treating vascular diseases. Danshensu (DSS) is...
Skin Barrier Recovery by Protease-Activated Receptor-2 Antagonist Lobaric Acid

Joo YA, Chung H, Yoon S, Park JI, Lee JE, Myung CH, Hwang JS

  • Biomol Ther.
  • 2016 Sep;24(5):529-535.
  • doi: 10.4062/biomolther.2016.011
Atopic dermatitis (AD) results from gene and environment interactions that lead to a range of immunological abnormalities and breakdown of the skin barrier. Protease-activated receptor 2 (PAR2) belongs to a...
Blockade of Urotensin II Receptor Prevents Vascular Dysfunction

Kim YA, Lee DG, Yi KY, Lee BH, Jung YS

  • Biomol Ther.
  • 2016 Sep;24(5):523-528.
  • doi: 10.4062/biomolther.2015.142
Urotensin II (UII) is a potent vasoactive peptide and mitogenic agent to induce proliferation of various cells including vascular smooth muscle cells (VSMCs). In this study, we examined the effects...
Roles of Dopamine D₂ Receptor Subregions in Interactions with β-Arrestin2

Zhang X, Choi BG, Kim KM

  • Biomol Ther.
  • 2016 Sep;24(5):517-522.
  • doi: 10.4062/biomolther.2015.198
β-Arrestins are one of the protein families that interact with G protein-coupled receptors (GPCRs). The roles of β-arrestins are multifaceted, as they mediate different processes including receptor desensitization, endocytosis, and...
Isoegomaketone Upregulates Heme Oxygenase-1 in RAW264.7 Cells via ROS/p38 MAPK/Nrf2 Pathway

Jin CH, So YK, Han SN, Kim JB

  • Biomol Ther.
  • 2016 Sep;24(5):510-516.
  • doi: 10.4062/biomolther.2015.194
Isoegomaketone (IK) was isolated from Perilla frutescens, which has been widely used as a food in Asian cuisine, and evaluated for its biological activity. We have already confirmed that IK...
Shikonin Induces Apoptotic Cell Death via Regulation of p53 and Nrf2 in AGS Human Stomach Carcinoma Cells

Ko H, Kim SJ, Shim SH, Chang H, Ha CH

  • Biomol Ther.
  • 2016 Sep;24(5):501-509.
  • doi: 10.4062/biomolther.2016.008
Shikonin, which derives from Lithospermum erythrorhizon, has been traditionally used against a variety of diseases, including cancer, in Eastern Asia. Here we determined that shikonin inhibits proliferation of gastric cancer...
Isoflurane Preconditioning Induces Neuroprotection by Up-Regulation of TREK1 in a Rat Model of Spinal Cord Ischemic Injury

Wang K, Kong X

  • Biomol Ther.
  • 2016 Sep;24(5):495-500.
  • doi: 10.4062/biomolther.2015.206
This study aimed to explore the neuroprotection and mechanism of isoflurane on rats with spinal cord ischemic injury. Total 40 adult male Sprague-Dawley rats were divided into the four groups...
Procaine Attenuates Pain Behaviors of Neuropathic Pain Model Rats Possibly via Inhibiting JAK2/STAT3

Li D, Yan Y, Yu L, Duan Y

  • Biomol Ther.
  • 2016 Sep;24(5):489-494.
  • doi: 10.4062/biomolther.2016.006
Neuropathic pain (NPP) is the main culprit among chronic pains affecting the normal life of patients. Procaine is a frequently-used local anesthesia with multiple efficacies in various diseases. However, its...
Involvement of NRF2 Signaling in Doxorubicin Resistance of Cancer Stem Cell-Enriched Colonospheres

Ryoo IG, Kim G, Choi BH, Lee SH, Kwak MK

  • Biomol Ther.
  • 2016 Sep;24(5):482-488.
  • doi: 10.4062/biomolther.2016.145
Cancer stem cells (CSCs) are a subset of tumor cells, which are characterized by resistance against chemotherapy and environmental stress, and are known to cause tumor relapse after therapy. A...
Functional Regulation of Dopamine D₃ Receptor through Interaction with PICK1

Zheng M, Zhang X, Min C, Choi BG, Oh IJ, Kim KM

  • Biomol Ther.
  • 2016 Sep;24(5):475-481.
  • doi: 10.4062/biomolther.2016.015
PICK1, a PDZ domain-containing protein, is known to increase the reuptake activities of dopamine transporters by increasing their expressions on the cell surface. Here, we report a direct and functional...
Pharmacological Activities and Applications of Spicatoside A

Ramalingam M, Kim SJ

  • Biomol Ther.
  • 2016 Sep;24(5):469-474.
  • doi: 10.4062/biomolther.2015.214
Liriopogons (Liriope and Opiopogon) species are used as a main medicinal ingredient in several Asian countries. The Liriopes Radix (tuber, root of Liriope platyphylla) has to be a promising candidate...
Proposal of Dual Inhibitor Targeting ATPase Domains of Topoisomerase II and Heat Shock Protein 90

Jun KY, Kwon Y

  • Biomol Ther.
  • 2016 Sep;24(5):453-468.
  • doi: 10.4062/biomolther.2016.168
There is a conserved ATPase domain in topoisomerase II (topo II) and heat shock protein 90 (Hsp90) which belong to the GHKL (gyrase, Hsp90, histidine kinase, and MutL) family. The...

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