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Pharmacokinetic Interaction of Chrysin with Caffeine in Rats

Noh K, Oh DG, Nepal MR, Jeong KS, Choi Y, Kang MJ, Kang W, Jeong HG, Jeong TC

  • Biomol Ther.
  • 2016 Jul;24(4):446-452.
  • doi: 10.4062/biomolther.2015.197
Pharmacokinetic interaction of chrysin, a flavone present in honey, propolis and herbs, with caffeine was investigated in male Sprague-Dawley rats. Because chrysin inhibited CYP1A-selective ethoxyresorufin O-deethylase and methoxyresorufin O-demethylase activities...
Identification of Neuroactive Constituents of the Ethyl Acetate Fraction from Cyperi Rhizoma Using Bioactivity-Guided Fractionation

Sim Y, Choi JG, Gu PS, Ryu B, Kim JH, Kang I, Jang DS, Oh MS

  • Biomol Ther.
  • 2016 Jul;24(4):438-445.
  • doi: 10.4062/biomolther.2016.091
Cyperi Rhizoma (CR), the rhizome of Cyperus rotundus L., exhibits neuroprotective effects in in vitro and in vivo models of neuronal diseases. Nevertheless, no study has aimed at finding the...
Salvia miltiorrhiza Bunge Blocks Ethanol-Induced Synaptic Dysfunction through Regulation of NMDA Receptor-Dependent Synaptic Transmission

Park HJ, Lee S, Jung JW, Lee YC, Choi SM, Kim DH

  • Biomol Ther.
  • 2016 Jul;24(4):433-437.
  • doi: 10.4062/biomolther.2015.184
Consumption of high doses of ethanol can lead to amnesia, which often manifests as a blackout. These blackouts experienced by ethanol consumers may be a major cause of the social...
Cytoprotective Mechanism of Cyanidin and Delphinidin against Oxidative Stress-Induced Tenofibroblast Death

Nam DC, Hah YS, Nam JB, Kim RJ, Park HB

  • Biomol Ther.
  • 2016 Jul;24(4):426-432.
  • doi: 10.4062/biomolther.2015.169
Age-related rotator cuff tendon degeneration is related to tenofibroblast apoptosis. Anthocyanins reduce oxidative stress-induced apoptotic cell death in tenofibroblasts. The current study investigated the presence of cell protective effects in...
Antinociceptive Effects of Prim-O-Glucosylcimifugin in Inflammatory Nociception via Reducing Spinal COX-2

Wu LQ, Li Y, Li YY, Xu SH, Yang ZY, Lin Z, Li J

  • Biomol Ther.
  • 2016 Jul;24(4):418-425.
  • doi: 10.4062/biomolther.2015.168
We measured anti-nociceptive activity of prim-o-glucosylcimifugin (POG), a molecule from Saposhnikovia divaricate (Turcz) Schischk. Anti-nociceptive or anti-inflammatory effects of POG on a formalin-induced tonic nociceptive response and a complete Freund's...
Differential Effects of Quercetin and Quercetin Glycosides on Human α7 Nicotinic Acetylcholine Receptor-Mediated Ion Currents

Lee BH, Choi SH, Kim HJ, Jung SW, Hwang SH, Pyo MK, Rhim H, Kim HC, Kim HK, Lee SM, Nah SY

  • Biomol Ther.
  • 2016 Jul;24(4):410-417.
  • doi: 10.4062/biomolther.2015.153
Quercetin is a flavonoid usually found in fruits and vegetables. Aside from its antioxidative effects, quercetin, like other flavonoids, has a various neuropharmacological actions. Quercetin-3-O-rhamnoside (Rham1), quercetin-3-O-rutinoside (Rutin), and quercetin-3-(2(G)-rhamnosylrutinoside...
Anti-Proliferative and Pro-Apoptotic Activities of 4-Methyl-2,6-bis(1-phenylethyl)phenol in Cancer Cells

Sung NY, Kim SC, Kim YH, Kim G, Lee Y, Sung GH, Kim JH, Yang WS, Kim MS, Baek KS, Kim JH, Cho JY

  • Biomol Ther.
  • 2016 Jul;24(4):402-409.
  • doi: 10.4062/biomolther.2015.166
It has been found that 4-isopropyl-2,6-bis(1-phenylethyl)phenol (KTH-13), a novel compound isolated from Cordyceps bassiana, is able to suppress tumor cell proliferation by inducing apoptosis. To mass-produce this compound, we established...
Aloe-Emodin Induces Chondrogenic Differentiation of ATDC5 Cells via MAP Kinases and BMP-2 Signaling Pathways

Yang M, Li L, Heo SM, Soh Y

  • Biomol Ther.
  • 2016 Jul;24(4):395-401.
  • doi: 10.4062/biomolther.2016.020
Endochondral bone formation is the process by which mesenchymal cells condense into chondrocytes, which are ultimately responsible for new bone formation. The processes of chondrogenic differentiation and hypertrophy are critical...
Trichostatin A Protects Liver against Septic Injury through Inhibiting Toll-Like Receptor Signaling

Kim SJ, Park JS, Lee DW, Lee SM

  • Biomol Ther.
  • 2016 Jul;24(4):387-394.
  • doi: 10.4062/biomolther.2015.176
Sepsis, a serious clinical problem, is characterized by a systemic inflammatory response to infection and leads to organ failure. Toll-like receptor (TLR) signaling is intimately implicated in hyper-inflammatory responses and...
Inhibition of Wnt Signaling by Silymarin in Human Colorectal Cancer Cells

Eo HJ, Park GH, Jeong JB

  • Biomol Ther.
  • 2016 Jul;24(4):380-386.
  • doi: 10.4062/biomolther.2015.154
Silymarin from milk thistle (Silybum marianum) has been reported to show an anti-cancer activity. In previous study, we reported that silymarin induces cyclin D1 proteasomal degradation through NF-κB-mediated threonine-286 phosphorylation....
Inhibition of Store-Operated Calcium Entry Protects Endothelial Progenitor Cells from Hâ‚‚Oâ‚‚-Induced Apoptosis

Wang YW, Zhang JH, Yu Y, Yu J, Huang L

  • Biomol Ther.
  • 2016 Jul;24(4):371-379.
  • doi: 10.4062/biomolther.2015.130
Store-operated calcium entry (SOCE), a major mode of extracellular calcium entry, plays roles in a variety of cell activities. Accumulating evidence indicates that the intracellular calcium ion concentration and calcium...
High Glucose Causes Human Cardiac Progenitor Cell Dysfunction by Promoting Mitochondrial Fission: Role of a GLUT1 Blocker

Choi HY, Park JH, Jang WB, Ji ST, Jung SY, Kim DY, Kang S, Kim YJ, Yun J, Kim JH, Baek SH, Kwon SM

  • Biomol Ther.
  • 2016 Jul;24(4):363-370.
  • doi: 10.4062/biomolther.2016.097
Cardiovascular disease is the most common cause of death in diabetic patients. Hyperglycemia is the primary characteristic of diabetes and is associated with many complications. The role of hyperglycemia in...
Marine Sponges as a Drug Treasure

Anjum K, Abbas SQ, Shah SA, Akhter N, Batool S, Hassan SS

  • Biomol Ther.
  • 2016 Jul;24(4):347-362.
  • doi: 10.4062/biomolther.2016.067
Marine sponges have been considered as a drug treasure house with respect to great potential regarding their secondary metabolites. Most of the studies have been conducted on sponge's derived compounds...

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