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Neurotoxicity of Synthetic Cannabinoids JWH-081 and JWH-210

Cha HJ, Seong YH, Song MJ, Jeong HS, Shin J, Yun J, Han K, Kim YH, Kang H, Kim HS

  • Biomol Ther.
  • 2015 Nov;23(6):597-603.
  • doi: 10.4062/biomolther.2015.057
Synthetic cannabinoids JWH-018 and JWH-250 in 'herbal incense' also called 'spice' were first introduced in many countries. Numerous synthetic cannabinoids with similar chemical structures emerged simultaneously and suddenly. Currently there...
Assessment of the Abuse Liability of Synthetic Cannabinoid Agonists JWH-030, JWH-175, and JWH-176

Tampus R, Yoon SS, de la Pena JB, Botanas CJ, Kim HJ, Seo JW, Jeong EJ, Jang CG, Cheong JH

  • Biomol Ther.
  • 2015 Nov;23(6):590-596.
  • doi: 10.4062/biomolther.2015.120
The emergence and use of synthetic cannabinoids have greatly increased in recent years. These substances are easily dispensed over the internet and on the streets. Some synthetic cannabinoids were shown...
Lifespan Extending and Stress Resistant Properties of Vitexin from Vigna angularis in Caenorhabditis elegans

Lee EB, Kim JH, Cha YS, Kim M, Song SB, Cha DS, Jeon H, Eun JS, Han S, Kim DK

  • Biomol Ther.
  • 2015 Nov;23(6):582-589.
  • doi: 10.4062/biomolther.2015.128
Several theories emphasize that aging is closely related to oxidative stress and disease. The formation of excess ROS can lead to DNA damage and the acceleration of aging. Vigna angularis...
Effect of Beta-Asarone on Impairment of Spatial Working Memory and Apoptosis in the Hippocampus of Rats Exposed to Chronic Corticosterone Administration

Lee B, Sur B, Cho SG, Yeom M, Shim I, Lee H, Hahm DH

  • Biomol Ther.
  • 2015 Nov;23(6):571-581.
  • doi: 10.4062/biomolther.2015.027
beta-asarone (BAS) is an active component of Acori graminei rhizoma, a traditional medicine used clinically in treating dementia and chronic stress in Korea. However, the cognitive effects of BAS and...
Peptidoglycan Up-Regulates CXCL8 Expression via Multiple Pathways in Monocytes/Macrophages

Lee CW, Chung SW, Bae MJ, Song S, Kim SP, Kim K

  • Biomol Ther.
  • 2015 Nov;23(6):564-570.
  • doi: 10.4062/biomolther.2015.053
Peptidoglycan (PG), the gram positive bacterial pathogen-associated molecular patterns (PAMP), is detected in a high proportion in macrophage-rich atheromatous regions, and expression of chemokine CXCL8, which triggers monocyte arrest on...
Diphlorethohydroxycarmalol Suppresses Ultraviolet B-Induced Matrix Metalloproteinases via Inhibition of JNK and ERK Signaling in Human Keratinocytes

Piao MJ, Susara Ruwan Kumara MH, Kim KC, Kang KA, Kang HK, Lee NH, Hyun JW

  • Biomol Ther.
  • 2015 Nov;23(6):557-563.
  • doi: 10.4062/biomolther.2015.054
Skin aging is the most readily observable process involved in human aging. Ultraviolet B (UVB) radiation causes photo-oxidation via generation of reactive oxygen species (ROS), thereby damaging the nucleus and...
Dimethyl Cardamonin Exhibits Anti-inflammatory Effects via Interfering with the PI3K-PDK1-PKCalpha Signaling Pathway

Yu WG, He H, Yao JY, Zhu YX, Lu YH

  • Biomol Ther.
  • 2015 Nov;23(6):549-556.
  • doi: 10.4062/biomolther.2015.048
Consumption of herbal tea [flower buds of Cleistocalyx operculatus (Roxb.) Merr. et Perry (Myrtaceae)] is associated with health beneficial effects against multiple diseases including diabetes, asthma, and inflammatory bowel disease....
EP2 Induces p38 Phosphorylation via the Activation of Src in HEK 293 Cells

Chun KS, Shim M

  • Biomol Ther.
  • 2015 Nov;23(6):539-548.
  • doi: 10.4062/biomolther.2015.043
Prostaglandin E2 (PGE2), a major product of cyclooxygenase, binds to four different prostaglandin E2 receptors (EP1, EP2, EP3, and EP4) which are G-protein coupled transmembrane receptors (GPCRs). Although GPCRs including...
Simvastatin Reduces Lipopolysaccharides-Accelerated Cerebral Ischemic Injury via Inhibition of Nuclear Factor-kappa B Activity

Anthony Jalin AMA, Lee JC, Cho GS, Kim C, Ju C, Pahk K, Song HY, Kim WK

  • Biomol Ther.
  • 2015 Nov;23(6):531-538.
  • doi: 10.4062/biomolther.2015.124
Preceding infection or inflammation such as bacterial meningitis has been associated with poor outcomes after stroke. Previously, we reported that intracorpus callosum microinjection of lipopolysaccharides (LPS) strongly accelerated the ischemia/reperfusion-evoked...
Vitamin C Stimulates Epidermal Ceramide Production by Regulating Its Metabolic Enzymes

Kim KP, Shin KO, Park K, Yun HJ, Mann S, Lee YM, Cho Y

  • Biomol Ther.
  • 2015 Nov;23(6):525-530.
  • doi: 10.4062/biomolther.2015.044
Ceramide is the most abundant lipid in the epidermis and plays a critical role in maintaining epidermal barrier function. Overall ceramide content in keratinocyte increases in parallel with differentiation, which...
Pretreatment with Lycopene Attenuates Oxidative Stress-Induced Apoptosis in Human Mesenchymal Stem Cells

Kim JY, Lee JS, Han YS, Lee JH, Bae I, Yoon YM, Kwon SM, Lee SH

  • Biomol Ther.
  • 2015 Nov;23(6):517-524.
  • doi: 10.4062/biomolther.2015.085
Human mesenchymal stem cells (MSCs) have been used in cell-based therapy to promote revascularization after peripheral or myocardial ischemia. High levels of reactive oxygen species (ROS) are involved in the...
Lipid A as a Drug Target and Therapeutic Molecule

Joo SH

  • Biomol Ther.
  • 2015 Nov;23(6):510-516.
  • doi: 10.4062/biomolther.2015.117
In this review, lipid A, from its discovery to recent findings, is presented as a drug target and therapeutic molecule. First, the biosynthetic pathway for lipid A, the Raetz pathway,...
Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted Cancer Therapeutics

Kim EG, Kim KM

  • Biomol Ther.
  • 2015 Nov;23(6):493-509.
  • doi: 10.4062/biomolther.2015.116
Antibody-drug conjugates utilize the antibody as a delivery vehicle for highly potent cytotoxic molecules with specificity for tumor-associated antigens for cancer therapy. Critical parameters that govern successful antibody-drug conjugate development...

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