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Effects of Baicalin on Oral Pharmacokinetics of Caffeine in Rats

Noh K, Nepal MR, Jeong KS, Kim SA, Um YJ, Seo CS, Kang MJ, Park PH, Kang W, Jeong HG, Jeong TC

  • Biomol Ther.
  • 2015 Mar;23(2):201-206.
  • doi: 10.4062/biomolther.2014.134
Scutellaria baicalensis is one of the most widely used herbal medicines in East Asia. Because baicalein and baicalin are major components of this herb, it is important to understand the...
Effect of Methotrexate on Collagen-Induced Arthritis Assessed by Micro-Computed Tomography and Histopathological Examination in Female Rats

Kim YH, Kang JS

  • Biomol Ther.
  • 2015 Mar;23(2):195-200.
  • doi: 10.4062/biomolther.2014.125
We tested the hypothesis that micro-computed tomography (micro-CT) analysis provides a better quantitative readout of the therapeutic potential of methotrexate (MTX) for treating collagen-induced arthritis (CIA) in rats and compared...
Functional Significance of Cytochrome P450 1A2 Allelic Variants, P450 1A2*8, *15, and *16 (R456H, P42R, and R377Q)

Lim YR, Kim IH, Han S, Park HG, Ko MJ, Chun YJ, Yun CH, Kim D

  • Biomol Ther.
  • 2015 Mar;23(2):189-194.
  • doi: 10.4062/biomolther.2015.009
P450 1A2 is responsible for the metabolism of clinically important drugs and the metabolic activation of environmental chemicals. Genetic variations of P450 1A2 can influence its ability to perform these...
Diallyl Disulfide Prevents Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats through the Inhibition of Oxidative Damage, MAPKs, and NF-kappaB Pathways

Kim SH, Lee IC, Ko JW, Moon C, Kim SH, Shin IS, Seo YW, Kim HC, Kim JC

  • Biomol Ther.
  • 2015 Mar;23(2):180-188.
  • doi: 10.4062/biomolther.2014.126
This study investigated the possible effects and molecular mechanisms of diallyl disulfide (DADS) against cyclophosphamide (CP)-induced hemorrhagic cystitis (HC) in rats. Inflammation response was assessed by histopathology and serum cytokines...
Hair Growth Promoting Potential of Phospholipids Purified from Porcine Lung Tissues

Choi SH, Moon JS, Jeon BS, Jeon YJ, Yoon BI, Lim CJ

  • Biomol Ther.
  • 2015 Mar;23(2):174-179.
  • doi: 10.4062/biomolther.2014.108
BP201, porcine lung tissue-derived phospholipids, consists of phosphatidylcholine as a major phospholipid species. BP201 promoted hair growth after application onto the shaved backs of BALB/c and C3H mice. Its effect...
Galangin (3,5,7-Trihydroxyflavone) Shields Human Keratinocytes from Ultraviolet B-Induced Oxidative Stress

Madduma Hewage SRK, Piao MJ, Kim KC, Cha JW, Han X, Choi YH, Chae S, Hyun JW

  • Biomol Ther.
  • 2015 Mar;23(2):165-173.
  • doi: 10.4062/biomolther.2014.130
Most skin damage caused by ultraviolet B (UVB) radiation is owing to the generation of reactive oxygen species. Phytochemicals can act as antioxidants against UVB-induced oxidative stress. This study investigated...
Spinosin, a C-Glucosylflavone, from Zizyphus jujuba var. spinosa Ameliorates Abeta1-42 Oligomer-Induced Memory Impairment in Mice

Ko SY, Lee HE, Park SJ, Jeon SJ, Kim B, Gao Q, Jang DS, Ryu JH

  • Biomol Ther.
  • 2015 Mar;23(2):156-164.
  • doi: 10.4062/biomolther.2014.110
Alzheimer's disease (AD) is a neurodegenerative disorder associated with progressive memory loss and neuronal cell death. Although numerous previous studies have been focused on disease progression or reverse pathological symptoms,...
Inhibitory Effects of Yuzu and Its Components on Human Platelet Aggregation

Kim TH, Kim HM, Park SW, Jung YS

  • Biomol Ther.
  • 2015 Mar;23(2):149-155.
  • doi: 10.4062/biomolther.2015.011
Our previous study demonstrated that yuzu has an anti-platelet effect in rat blood. In the present study, we examined whether the anti-platelet effect of yuzu can be extended to human...
Cardamonin Suppresses TGF-beta1-Induced Epithelial Mesenchymal Transition via Restoring Protein Phosphatase 2A Expression

Kim EJ, Kim HJ, Park MK, Kang GJ, Byun HJ, Lee H, Lee CH

  • Biomol Ther.
  • 2015 Mar;23(2):141-148.
  • doi: 10.4062/biomolther.2014.117
Epithelial mesenchymal transition (EMT) is the first step in metastasis and implicated in the phenotype of cancer stem cells. Therefore, understanding and controlling EMT, are essential to the prevention and...
ATF3 Mediates Anti-Cancer Activity of Trans-10, cis-12-Conjugated Linoleic Acid in Human Colon Cancer Cells

Kim KJ, Lee J, Park Y, Lee SH

  • Biomol Ther.
  • 2015 Mar;23(2):134-140.
  • doi: 10.4062/biomolther.2014.107
Conjugated linoleic acids (CLA) are a family of isomers of linoleic acid. CLA increases growth arrest and apoptosis of human colorectal cancer cells through an isomer-specific manner. ATF3 belongs to...
The Cytotoxicity of Kahweol in HT-29 Human Colorectal Cancer Cells Is Mediated by Apoptosis and Suppression of Heat Shock Protein 70 Expression

Choi DW, Lim MS, Lee JW, Chun W, Lee SH, Nam YH, Park JM, Choi DH, Kang CD, Lee SJ, Park SC

  • Biomol Ther.
  • 2015 Mar;23(2):128-133.
  • doi: 10.4062/biomolther.2014.133
Although coffee is known to have antioxidant, anti-inflammatory, and antitumor properties, there have been few reports about the effect and mechanism of coffee compounds in colorectal cancer. Heat shock proteins...
Inhibitory Effect of 3-(4-Hydroxyphenyl)-1-(thiophen-2-yl) prop-2-en-1-one, a Chalcone Derivative on MCP-1 Expression in Macrophages via Inhibition of ROS and Akt Signaling

Kim MJ, Kadayat T, Um YJ, Jeong TC, Lee ES, Park PH

  • Biomol Ther.
  • 2015 Mar;23(2):119-127.
  • doi: 10.4062/biomolther.2014.127
Chalcones (1,3-diaryl-2-propen-1-ones), a subfamily of flavonoid, are widely known to possess potent anti-inflammatory and anti-oxidant properties. In this study, we investigated the effect of 3-(4-Hydroxyphenyl)-1-(thio3-(4-Hydroxyphenyl phen-2-yl)prop-2-en-1-one (TI-I-175), a synthetic chalcone...
Shikonin Isolated from Lithospermum erythrorhizon Downregulates Proinflammatory Mediators in Lipopolysaccharide-Stimulated BV2 Microglial Cells by Suppressing Crosstalk between Reactive Oxygen Species and NF-kappaB

Prasad RG, Choi YH, Kim GY

  • Biomol Ther.
  • 2015 Mar;23(2):110-118.
  • doi: 10.4062/biomolther.2015.006
According to the expansion of lifespan, neuronal disorder based on inflammation has been social problem. Therefore, we isolated shikonin from Lithospermum erythrorhizon and evaluated anti-inflammatory effects of shikonin in lipopolysaccharide...
Cancer Metabolism: Strategic Diversion from Targeting Cancer Drivers to Targeting Cancer Suppliers

Kim SY

  • Biomol Ther.
  • 2015 Mar;23(2):99-109.
  • doi: 10.4062/biomolther.2015.013
Drug development groups are close to discovering another pot of gold-a therapeutic target-similar to the success of imatinib (Gleevec) in the field of cancer biology. Modern molecular biology has improved...

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