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Cardiovascular Safety Pharmacology of Sibutramine

Yun J, Chung E, Choi KH, Cho DH, Song YJ, Han KM, Cha HJ, Shin JS, Seong WK, Kim YH, Kim HS

  • Biomol Ther.
  • 2015 Jul;23(4):386-389.
  • doi: 10.4062/biomolther.2015.033
Sibutramine is an anorectic that has been banned since 2010 due to cardiovascular safety issues. However, counterfeit drugs or slimming products that include sibutramine are still available in the market....
Evaluation of Eye Irritation Potential of Solid Substance with New 3D Reconstructed Human Cornea Model, MCTT HCE(TM)

Jang WH, Jung KM, Yang HR, Lee M, Jung HS, Lee SH, Park M, Lim KM

  • Biomol Ther.
  • 2015 Jul;23(4):379-385.
  • doi: 10.4062/biomolther.2015.004
The eye irritation potential of drug candidates or pharmaceutical ingredients should be evaluated if there is a possibility of ocular exposure. Traditionally, the ocular irritation has been evaluated by the...
Effects of Resveratrol Supplementation on Oxidative Damage and Lipid Peroxidation Induced by Strenuous Exercise in Rats

Xiao NN

  • Biomol Ther.
  • 2015 Jul;23(4):374-378.
  • doi: 10.4062/biomolther.2015.015
The purpose of the present study was to investigate the effects of resveratrol supplementation on oxidative damage and lipid peroxidation induced by strenuous exercise in rats. The rats were randomly...
Pro-Apoptotic Activity of 4-Isopropyl-2-(1-Phenylethyl) Aniline Isolated from Cordyceps bassiana

Kim MS, Lee Y, Sung GH, Kim JH, Park JG, Kim HG, Baek KS, Cho JH, Han J, Lee KH, Hong S, Kim JH, Cho JY

  • Biomol Ther.
  • 2015 Jul;23(4):367-373.
  • doi: 10.4062/biomolther.2015.021
Cordyceps species including Cordyceps bassiana are a notable anti-cancer dietary supplement. Previously, we identified several compounds with anti-cancer activity from the butanol fraction (Cb-BF) of Cordyceps bassiana. To expand the...
Isorhamnetin Protects Human Keratinocytes against Ultraviolet B-Induced Cell Damage

Han X, Piao MJ, Kim KC, Madduma Hewage SRK, Yoo ES, Koh YS, Kang HK, Shin JH, Park Y, Yoo SJ, Chae S, Hyun JW

  • Biomol Ther.
  • 2015 Jul;23(4):357-366.
  • doi: 10.4062/biomolther.2015.005
Isorhamnetin (3-methylquercetin) is a flavonoid derived from the fruits of certain medicinal plants. This study investigated the photoprotective properties of isorhamnetin against cell damage and apoptosis resulting from excessive ultraviolet...
The Pharmacological Effects of Benachio-F(R) on Rat Gastrointestinal Functions

Poudel BK, Yu JY, Kwon YS, Park HG, Son M, Jun JH, Kim JA, Kim JO

  • Biomol Ther.
  • 2015 Jul;23(4):350-356.
  • doi: 10.4062/biomolther.2015.035
Functional dyspepsia (FD) is a prevalent idiopathic upper gastrointestinal (GI) disorder characterized by diverse symptomatology including epigastric pain or discomfort, postprandial fullness, and early satiety. Although its pathophysiological mechanisms have...
Anti-Influenza Activity of Betulinic Acid from Zizyphus jujuba on Influenza A/PR/8 Virus

Hong EH, Song JH, Kang KB, Sung SH, Ko HJ, Yang H

  • Biomol Ther.
  • 2015 Jul;23(4):345-349.
  • doi: 10.4062/biomolther.2015.019
Betulinic acid, a pentacyclic triterpene isolated from Jujube tree (Zizyphus jujuba Mill), has been known for a wide range of biological and medicinal properties such as antibacterial, antimalarial, anti-inflammatory, antihelmintic,...
Anti-Proliferative Effect of Naringenin through p38-Dependent Downregulation of Cyclin D1 in Human Colorectal Cancer Cells

Song HM, Park GH, Eo HJ, Lee JW, Kim MK, Lee JR, Lee MH, Koo JS, Jeong JB

  • Biomol Ther.
  • 2015 Jul;23(4):339-344.
  • doi: 10.4062/biomolther.2015.024
Naringenin (NAR) as one of the flavonoids observed in grapefruit has been reported to exhibit an anti-cancer activity. However, more detailed mechanism by which NAR exerts anti-cancer properties still remains...
Chitin from Cuttlebone Activates Inflammatory Cells to Enhance the Cell Migration

Lim SC, Lee KM, Kang TJ

  • Biomol Ther.
  • 2015 Jul;23(4):333-338.
  • doi: 10.4062/biomolther.2015.062
Our previous report showed that the extract from cuttlebone (CB) had wound healing effect in burned lesion of rat and the extract was identified as chitin by HPLS analysis. We...
Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells

Shin JH, Bae DJ, Kim ES, Kim HB, Park SJ, Jo YK, Jo DS, Jo DG, Kim SY, Cho DH

  • Biomol Ther.
  • 2015 Jul;23(4):327-332.
  • doi: 10.4062/biomolther.2015.025
Primary cilia have critical roles in coordinating multiple cellular signaling pathways. Dysregulation of primary cilia is implicated in various ciliopathies. To identify specific regulators of autophagy, we screened chemical libraries...
Induction of Resistance to BRAF Inhibitor Is Associated with the Inability of Spry2 to Inhibit BRAF-V600E Activity in BRAF Mutant Cells

Ahn JH, Han BI, Lee M

  • Biomol Ther.
  • 2015 Jul;23(4):320-326.
  • doi: 10.4062/biomolther.2015.007
The clinical benefits of oncogenic BRAF inhibitor therapies are limited by the emergence of drug resistance. In this study, we investigated the role of a negative regulator of the MAPK...
An Aminopropyl Carbazole Derivative Induces Neurogenesis by Increasing Final Cell Division in Neural Stem Cells

Shin JY, Kong SY, Yoon HJ, Ann J, Lee J, Kim HJ

  • Biomol Ther.
  • 2015 Jul;23(4):313-319.
  • doi: 10.4062/biomolther.2015.016
P7C3 and its derivatives, 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(p-tolylamino)propan-2-ol (1) and N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-hydroxypropyl)-N-(3-methoxyphenyl)-4-methylbenzenesulfonamide (2), were previously reported to increase neurogenesis in rat neural stem cells (NSCs). Although P7C3 is known to increase neurogenesis by protecting...
Phosphorylation and Reorganization of Keratin Networks: Implications for Carcinogenesis and Epithelial Mesenchymal Transition

Kim HJ, Choi WJ, Lee CH

  • Biomol Ther.
  • 2015 Jul;23(4):301-312.
  • doi: 10.4062/biomolther.2015.032
Metastasis is one of hallmarks of cancer and a major cause of cancer death. Combatting metastasis is highly challenging. To overcome these difficulties, researchers have focused on physical properties of...

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