- Biodistribution of Exosomes and Engineering Strategies for Targeted Delivery of Therapeutic Exosomes
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Choi H, Choi Y, Yim HY, Mirzaaghasi A, Yoo JK, Choi C
- KMID: 2519208
- Tissue Eng Regen Med.
- 2021 Aug;18(4):499-511.
- doi: 10.1007/s13770-021-00361-0
Exosomes are cell-secreted nano-sized vesicles which deliver diverse biological molecules for intercellular communication. Due to their therapeutic potential, exosomes have been engineered in numerous ways for efficient delivery of active... -
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- Radioisotope-ADME studies of Trastuzumab-monomethyl auristatin F in tumor bearing mice and healthy marmosets
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Lee HW, Jeong YH, Hwang JA, Lee JJ, Yu AR, Kang JA, Raza MA, Park SH, Park YH, Kim DH
- KMID: 2503833
- J Biomed Transl Res.
- 2020 Jun;21(2):79-90.
- doi: 10.12729/jbtr.2020.21.2.079
Radioisotope ADME (RI-ADME) studies are enabling visualization of the biodistribution in molecular imaging. We applied RI-ADME to investigate the tumor targeting capacity and biodistribution of trastuzumab-monomethyl auristatin F (LCB14-0110) in... -
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- In vivo Imaging Biodistribution Profile of a New Macrocyclic Gadolinium Chelate as a Highly Stable Multifunctional MRI Contrast Agent
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Sung BK, Jo YW, Chang Y
- KMID: 2442231
- Investig Magn Reson Imaging.
- 2019 Mar;23(1):34-37.
- doi: 10.13104/imri.2019.23.1.34
Gadolinium contrast agents (CAs) are integral components of clinical magnetic resonance imaging (MRI). However, safety concerns have arisen regarding the use of gadolinium CAs, due to their association with nephrogenic... -
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- ¹²³I-Labeled oxLDL Is Widely Distributed Throughout the Whole Body in Mice
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Nakano A, Kawashima , Miyake Y, Zeniya T, Yamamoto A, Koshino K, Temma T, Fukuda T, Fujita Y, Kakino A, Kanaya S, Sawamura T, Iida H
- KMID: 2414802
- Nucl Med Mol Imaging.
- 2018 Apr;52(2):144-153.
- doi: 10.1007/s13139-017-0497-2
PURPOSE: Oxidized low-density lipoprotein (oxLDL) plays a key role in endothelial dysfunction, vascular inflammation, and atherogenesis. The aim of this study was to assess blood clearance and in vivo kinetics... -
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- Altered Biodistribution of (99m)Tc-DPD on Bone Scan After Intravenous Iron Supplement
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Shin E, Oh M, Sung C, Kim KH, Ryu JS
- KMID: 2403508
- Nucl Med Mol Imaging.
- 2017 Dec;51(4):347-349.
- doi: 10.1007/s13139-017-0486-5
We report a casewith altered biodistribution of (99m)Tc-dicarboxypropane diphosphonate ((99m)Tc-DPD) on whole body bone scan after intravenous iron supplement therapy. A 47-year-old male patient who had recently been detected with... -
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- Comparative in vivo biodistributions of nanoparticles and polymers of ¹â·â·lutetium-labeled hyaluronic acids in mice during 28 days
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Lin C, Jeong JY, Yon JM, Park SG, Gwon LW, Lee JG, Baek IJ, Nahm SS, Lee BJ, Yun YW, Nam SY
- KMID: 2386851
- Korean J Vet Res.
- 2017 Jun;57(2):105-111.
- doi: 10.14405/kjvr.2017.57.2.105
Hyaluronic acid (HA) has been investigated for biomedical and pharmaceutical applications. This study was conducted to determine the distributions of HA nanoparticles (NPs; size 350–400 nm) and larger HA polymers... -
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- Preparation and Evaluation of 68Ga-ECC as a PET Renal Imaging Agent
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Mirzaei A, Jalilian A, Aghanejad , Mazidi M, Yousefnia , Shabani G, Ardaneh K, Geramifar , Beiki D
- KMID: 2052055
- Nucl Med Mol Imaging.
- 2015 Sep;49(3):208-216.
- doi: 10.1007/s13139-015-0323-7
PURPOSE: Development of a gallium-68-labeled renal tracer can be a good substitute for Tc-99m, a known SPECT tracer. In this study, effort was made to develop 68Gaethylenecysteamine cysteine (68Ga-ECC). METHODS: Ga-ECC... -
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- Distribution and accumulation of 177Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles in the tissues of ICR mice
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Hue JJ, Lee HJ, Nam SY, Kim JS, Lee BJ, Yun YW
- KMID: 2128681
- Korean J Vet Res.
- 2015 Mar;55(1):57-60.
- doi: 10.14405/kjvr.2015.55.1.57
To investigate kinetics of free 177Lu and 177Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION), suspensions were intravenously injected into the tail vein of mice at a dose of 5... -
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- Evaluation of thermally cross-linked superparamagnetic iron oxide nanoparticles for the changes of concentration and toxicity on tissues of Sprague-Dawley rats
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Hue JJ, Lee HJ, Jon S, Nam SY, Yun YW, Kim JS, Lee BJ
- KMID: 2307890
- Korean J Vet Res.
- 2014 Dec;54(4):245-252.
- doi: 10.14405/kjvr.2014.54.4.245
This study was investigated the change of concentration and toxicity of thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION) on tissues of Sprague-Dawley rats. TCL-SPION at the dose of 15 mg/kg... -
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- Distribution and accumulation of Cy5.5-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles in the tissues of ICR mice
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Hue JJ, Lee HJ, Jon S, Nam SY, Yun YW, Kim JS, Lee BJ
- KMID: 1712315
- J Vet Sci.
- 2013 Dec;14(4):473-479.
- doi: 10.4142/jvs.2013.14.4.473
Free Cy5.5 dye and Cy5.5-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION) have been routinely used for in vivo optical imaging. However, there is little information about the distribution and... -
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- Biodistribution of 99mTc Labeled Integrin Antagonist
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Jang BS, Park SH, Shin IS, Maeng JS, Paik CH
- KMID: 2317812
- Toxicol Res.
- 2013 Mar;29(1):21-25.
The selective targeting of an integrin alphavbeta3 receptor using radioligands may enable the assessment of angiogenesis and integrin alphavbeta3 receptor status in tumors. The aim of this research was to... -
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- Development of a 68Ga-Fluorinated Porphyrin Complex as a Possible PET Imaging Agent
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Fazaeli Y, Jalilian A, Amini MM, Ardaneh K, Rahiminejad A, Bolourinovin F, Moradkhani S, Majdabadi
- KMID: 1433598
- Nucl Med Mol Imaging.
- 2012 Mar;46(1):20-26.
AIM: Due to the interesting pharmacologic properties of porphyrins, the idea of developing a possible tumor imaging agent using PET by incorporating 68Ga into a suitable porphyrin ligand was investigated. METHODS:... -
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- Development of 166Ho-phytate Complex for Radiosynovectomy
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Jalilian A, Anvari A, Bahrami-Samani A, Mazidi M, Ghannadi-Maragheh M
- KMID: 2313131
- Nucl Med Mol Imaging.
- 2011 Jun;45(2):87-92.
BACKGROUND: 66Ho-chloride was obtained by bombardment of natural Ho(NO3)3 dissolved in acidic media using thermal neutron flux (4-5x10(13) n.cm(-2).s(-1)). METHODS: 166Ho-holmium chloride (185 MBq) was used successfully for preparation of 166Ho-phytate... -
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- Multifunctional Nanoparticles for Molecular Imaging
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Kang E, Kim K, Kwon IC
- KMID: 1469547
- J Korean Med Assoc.
- 2009 Feb;52(2):125-134.
- doi: 10.5124/jkma.2009.52.2.125
Molecular imaging is a bioimaging that can detect biochemically and genetically relevant events in molecular level in cells and tissues via quantitative imaging signal. Molecular imaging provides potential advantages to... -
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- Biodistribution and Hepatic Metabolism of Galactosylated 111In-Antibody-Chelator Conjugates: Comparison with 111In-Antibody-Chelator Conjugates
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Kwak DS, Lee J, Jeong KS, Ha JH, Ahn BC, Lee K, Paik CH
- KMID: 1516876
- Korean J Nucl Med.
- 2003 Dec;37(6):402-417.
PURPOSE: To evaluate the use of monoclonal antibody (MoAb) as a carrier of the receptor-binding ligand, the receptor mediated uptake into liver and subsequent metabolism of (111) In-labeled galactosylated MoAb-chelator... -
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- Preparation and Biodistribution of Re-188-Sulfur Colloid Suspension in Lipiodol
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Kim YJ, Jeong JM, Kim SK, Son M, Lee DS, Chung JK, Lee MC
- KMID: 2078743
- Korean J Nucl Med.
- 2003 Oct;37(5):301-307.
PURPOSE: Lipiodol is used for targeting liver cancers by administrating through the hepatic artery. In the present study, feasibility of Re-188-sulfur colloid suspension in lipiodol as a liver cancer targeting... -
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- Biodistribution of Iodine-131-Iodomisonidazole and Imaging of Tumor Hypoxia in Mice bearing CT-26 Adenocarcinoma
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Kim HW, Kim CG, Yoon KH, Kim HJ, Juhng SK, Roh BS, Yang DJ, Kim EE, Lee HC
- KMID: 1926584
- Korean J Nucl Med.
- 1999 Jun;33(3):289-297.
urpose: Misonidazole is a radiosensitizer that binds in hypoxic cells. The purpose of this study was to find out the feasibility of I-131-Iodomisonidazole (IMISO) for imaging of tumor hypoxia. MATERIALS... -
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- Comparison of Direct-labeling Method of Antibody with 99mTc and 188Re
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Choi TH, Lim SM, Choi CW, Woo KS, Chung WS, Lim SJ
- KMID: 1556306
- Korean J Nucl Med.
- 1999 Feb;33(1):84-93.
PURPOSE: We investigated the direct labeling method of antibody with 99mTc and 188Re and examined the stability and function of these labeled compounds in in vitro and in vivo. MATERIALS... -
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- Biodistribution and Scintigraphy of Iodine-131-Iododeoxyadenosine in Rats Bearing Breast Cancer
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Kim SG, Kim CG, Lee KM, Kim HW, Min BC, Choi SS, Lee JD, Yang DJ, Kim EE, Lee HC, Won JJ
- KMID: 2078714
- Korean J Nucl Med.
- 1998 Aug;32(4):374-381.
PURPOSE: I-131 labeled (2'-deoxy-2-iodo-p-D-arabinofuranosyl) adenine (IAD) may be involved in DNA synthesis during active proliferation of tumor cells. We conducted this study to find out the biodistribution of IAD and... -
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- Preparation and Biodistribution of Re-188 Sulfru Colloid
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Kim YJ, Jeong JM, Chang YS, Lee YJ, Lee DS, Chung JK, Lee MC, Song YW
- KMID: 2078690
- Korean J Nucl Med.
- 1998 Jun;32(3):298-304.
PURPOSE: We evaluated the usefulness of Re-188 sulfur colloid for radiation synovectomy and therapy of intraperitoneal metastasis. MATERIALS AND METHODS: We investigated the labeling efficiency of Re-188 sulfur colloid on... -
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