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Effect of long term high altitude exposure on cardiovascular autonomic adjustment during rest and post-exercise recovery

Bhattarai , Paudel BH, Thakur D, Bhattarai , Subedi B, Khadka R

BACKGROUND: Despite the successful adaptation to high altitude, some differences do occur due to long term exposure to the hypoxic environment. The effect of long term high altitude exposure on...
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New-Onset Mania Following Bariatric Surgery

Nepal H, Bhattarai , Agustin ET

Obesity has become a major public health problem over the past two decades. Non-surgical management of obesity does not often achieve its long term goals. Surgical treatment is roaring in...
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Complex Regional Pain Syndrome (CRPS type-1) in an Adolescent Following Extravasation of Dextrose Containing Fluid-an Underdiagnosed Case

Subedi A, Bhattarai , Biswas BK, Khatiwada

Due to its complex pathophysiology and wide spectrum of clinical manifestations, the diagnosis of CRPS is often missed in the early stage by primary care physicians. After being treated by...
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Double versus single cartridge of 4% articaine infiltration into the retro-molar area for lower third molar surgery

Sawang K, Chaiyasamut T, Kiattavornchareon S, Pairuchvej V, Bhattarai , Wongsirichat N

BACKGROUND: There are no studies regarding 4% articaine infiltration injection into the retro-molar area for an impacted lower third molar (LITM) surgery. This study aimed to evaluate the efficacy of...
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Pattern of Thyroid Dysfunction in Patients with Metabolic Syndrome and Its Relationship with Components of Metabolic Syndrome

Gyawali P, Takanche J, Shrestha R, Bhattarai , Khanal K, Risal P, Koju R

BACKGROUND: Thyroid dysfunction (TD) and metabolic syndrome (MetS) are known risk factors for atherosclerotic cardiovascular disease (ASCVD). TD is risk factor for ASCVD mediated by the effects of thyroid hormones...
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An epidemiological study on the prevalence of temporomandibular disorder and associated history and problems in Nepalese subjects

Rokaya D, Suttagul K, Joshi S, Bhattarai , Shah PK, Dixit S

BACKGROUND: Temporomandibular disorder (TMD) represents a subgroup of painful orofacial disorders involving pain in the temporomandibular joint (TMJ) region, fatigue of the cranio-cervico-facial muscles (especially masticatory muscles), limitation of mandible...
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Effects of human growth hormone on gonadotropin-releasing hormone neurons in mice

Bhattarai , Kim SH, Han SK, Park MJ

PURPOSE: Recombinant human growth hormone (rhGH) has been widely used to treat short stature. However, there are some concerns that growth hormone treatment may induce skeletal maturation and early onset...
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PPARgamma Inhibits Inflammation through the Suppression of ERK1/2 Kinase Activity in Human Gingival Fibroblasts

Lee YH, Kwak DH, Kang MS, Bhattarai , Lee NH, Jhee EC, Yi HK

  • KMID: 1719930
  • Int J Oral Biol.
  • 2010 Mar;35(1):27-33.
Periodontal disease is a major oral disorder and comprises a group of infections that lead to inflammation of the gingiva and the destruction of periodontal tissues. PPARgamma plays an important...
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Korean red ginseng excitation of paraventricular nucleus neurons via non-N-methyl-D-aspartate glutamate receptor activation in mice

Shen Y, Bhattarai , Park SJ, Lee GS, Ryu PD, Han SK

It has been reported that Korean red ginseng (KRG), a valuable and important traditional medicine, has varied effects on the central nervous system, suggesting its activities are complicated. The paraventricular...
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PI3Kδ contributes to ER stress-associated asthma through ER-redox disturbances: the involvement of the RIDD–RIG-I–NF-κB axis

Kim HK, Lee GH, Bhattarai , Junjappa R, Lee HY, Handigund , Marahatta , Bhandary B, Baek IH, Pyo JS, Kim HK, Chai OH, Kim HR, Lee YC, Chae HJ

Hyperactivation of phosphoinositol 3-kinase (PI3K) has been suggested to be a potential mechanism for endoplasmic reticulum (ER) stress-enhanced airway hyperresponsiveness, and PI3K inhibitors have been examined as asthma therapeutics. However,...
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Age-dependent Kisspeptin Effects on the GnRH Neurons in Male and Female Mice

Bhattarai , Park SA, Yin H, Park SJ, Jeon JG, Chang KW, Lee SY, Ryu PD, Han SK

BACKGROUND: The gonadotropin releasing hormone (GnRH) neurons play a pivotal role in the central regulation of fertility. Kisspeptin binds to the G-protein coupled receptor 54 (GPR54) and GPR54 has been...
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Somatostatin Inhibits Gonadotropin Releasing Hormone Neuronal Activities in Juvenile Mice

Park SA, Bhattarai , Han SK

BACKGROUND: The gonadotropin releasing hormone (GnRH) neurons perform a pivotal function in the central regulation of fertility. Somatostatin (SST) is an important neuromodulatory peptide in the central nervous system and...
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