- Effect of L-carnitine on the expression of the apoptotic genes Bcl-2 and Bax
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Vardiyan R, Ezati D, Anvari M, Ghasemi N, Talebi A
- KMID: 2506132
- Clin Exp Reprod Med.
- 2020 Sep;47(3):155-160.
- doi: 10.5653/cerm.2019.03440
Objective The genes Bcl-2 and Bax play important roles in apoptosis. Many studies have shown that formalin has a strong deleterious effect on male fertility and can induce apoptosis. L-carnitine... -
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- Synergistic Induction of Apoptosis by the Combination of an Axl Inhibitor and Auranofin in Human Breast Cancer Cells
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Ryu YS, Shin S, An HG, Kwon TU, Baek HS, Kwon YJ, Chun YJ
- KMID: 2505693
- Biomol Ther.
- 2020 Sep;28(5):473-481.
- doi: 10.4062/biomolther.2020.051
Axl receptor tyrosine kinase has been implicated in cancer progression, invasion, and metastasis in various cancer types. Axl overexpression has been observed in many cancers, and selective inhibitors of Axl,... -
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- Subgroup analysis of a phase 2/3 study of rurioctocog alfa pegol in patients with severe hemophilia A: efficacy and safety in previously treated Korean patients
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You CW, Baek HJ, Park SK, Park YS, Shin HJ, Engl W, Tangada S
- KMID: 2459385
- Blood Res.
- 2019 Sep;54(3):198-203.
- doi: 10.5045/br.2019.54.3.198
BACKGROUND: The efficacy and safety of extended half-life, full-length, pegylated recombinant factor VIII rurioctocog alfa pegol [BAX 855, ADYNOVATE (USA)/ADYNOVI (Europe); Baxalta US Inc., a Takeda company, Lexington, MA, USA]... -
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- Investigation of BAX and BCL2 expression and apoptosis in a resveratrol- and prednisolone-treated human T-ALL cell line, CCRF-CEM
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Khanzadeh , Hagh MF, Talebi M, Yousefi B, Azimi A, Hossein pour feizi AA, Baradaran
- KMID: 2414365
- Blood Res.
- 2018 Mar;53(1):53-60.
- doi: 10.5045/br.2018.53.1.53
BACKGROUND: The numerous side effects and chemo-resistance of conventional chemical drugs in the treatment of malignancies have led to consideration of the anti-cancer properties of natural products. In the present... -
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- Anti-proliferative Effects of Androctonus amoreuxi Scorpion and Cerastes cerastes Snake Venoms on Human Prostate Cancer Cells
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Akef H, Kotb N, Abo-Elmatty D, Salem S
- KMID: 2375547
- J Cancer Prev.
- 2017 Mar;22(1):40-46.
- doi: 10.15430/JCP.2017.22.1.40
The present study evaluated the effects of Androctonus amoreuxi scorpion venom, Cerastes cerastes snake venom and their mixture on prostate cancer cells (PC3). An MTT assay was used to determine... -
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- Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells
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Lee J, Hong EM, Jang JA, Park SW, Koh DH, Choi MH, Jang HJ, Kae SH
- KMID: 2363978
- Gut Liver.
- 2016 Mar;10(2):310-317.
- doi: 10.5009/gnl15195
BACKGROUND/AIMS: Statins act as antineoplastic agents through the inhibition of cell proliferation. This study sought to demonstrate the effects of statins on extrahepatic bile duct cancer cell apoptosis and to... -
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- Effects of Repetitive Transcranial Magnetic Stimulation on Behavioral Recovery during Early Stage of Traumatic Brain Injury in Rats
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Yoon KJ, Lee YT, Chung PW, Lee YK, Kim DY, Chun MH
- KMID: 2344185
- J Korean Med Sci.
- 2015 Oct;30(10):1496-1502.
- doi: 10.3346/jkms.2015.30.10.1496
Repetitive transcranial magnetic stimulation (rTMS) is a promising technique that modulates neural networks. However, there were few studies evaluating the effects of rTMS in traumatic brain injury (TBI). Herein, we... -
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- Role of Annexin A5 on Mitochondria-Dependent Apoptosis Induced by Tetramethoxystilbene in Human Breast Cancer Cells
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Hong M, Park N, Chun YJ
- KMID: 2170593
- Biomol Ther.
- 2014 Nov;22(6):519-524.
- doi: 10.4062/biomolther.2014.112
We have previously shown that 2,4,3',5'-tetramethoxystilbene (TMS), a trans-stilbene analogue, induces apoptosis in human cancer cells. However, the detailed mechanisms of mitochondria-dependent apoptosis induced by TMS are not fully understood.... -
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- Regulatory Role of Autophagy in Globular Adiponectin-Induced Apoptosis in Cancer Cells
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Nepal S, Park PH
- KMID: 2380314
- Biomol Ther.
- 2014 Sep;22(5):384-389.
- doi: 10.4062/biomolther.2014.021
Adiponectin, an adipokine predominantly secreted from adipose tissue, exhibits diverse biological responses, including metabolism of glucose and lipid, and apoptosis in cancer cells. Recently, adiponectin has been shown to modulate... -
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- Neuroprotective Effect of Steamed and Fermented Codonopsis lanceolata
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Weon JB, Yun BR, Lee J, Eom MR, Ko HJ, Lee HY, Park DS, Chung HC, Chung JY, Ma CJ
- KMID: 2170643
- Biomol Ther.
- 2014 May;22(3):246-253.
Codonopsis lanceolata has been used as an herbal medicine for several lung infl ammatory diseases, such as asthma, tonsillitis, and pharyngitis. Previously, we showed the neuroprotective effect of steamed and... -
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- Effects of Chronic Mild Stress in Female Bax Inhibitor-1-Gene Knockout Mice
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Sui ZY, Chae HJ, Huang GB, Zhao T, Shrestha Muna S, Chung YC
- KMID: 1432537
- Clin Psychopharmacol Neurosci.
- 2012 Dec;10(3):155-162.
- doi: 10.9758/cpn.2012.10.3.155
OBJECTIVE: The anti-apoptotic protein Bax inhibitor-1 (BI-1) is a regulator of apoptosis linked to endoplasmic reticulum (ER) stress, and BI-1-/- mice exhibit increased sensitivity to tissue damage. The purpose of... -
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- Induction of the Intrinsic Apoptotic Pathway by 3-Deazaadenosine Is Mediated by BAX Activation in HL-60 Cells
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Lee SY, Ko KW, Kang WK, Choe YJ, Kim YH, Kim IK, Kim J, Kim HS
- KMID: 2071713
- Korean J Physiol Pharmacol.
- 2010 Dec;14(6):407-412.
- doi: 10.4196/kjpp.2010.14.6.407
3-Deazaadenosine (DZA), a potent inhibitor of S-adenosylhomocysteine hydrolase, was previously proposed to induce intrinsic apoptosis in human leukemic cells. In the present study, we analyzed the mechanism underlying the DZA-induced... -
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- Expression of ErbB4 in the apoptotic neurons of Alzheimer's disease brain
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Woo RS, Lee JH, Yu HN, Song DY, Baik TK
- KMID: 1455348
- Anat Cell Biol.
- 2010 Dec;43(4):332-339.
- doi: 10.5115/acb.2010.43.4.332
Neuregulin-1 (NRG1) signaling participates in the synaptic plasticity, maintenance or regulation of adult brain. Although ErbB4, a key NRG1 receptor, is expressed in multiple regions in the adult animal brain,... -
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- The neuroprotective effect of recombinant human erythropoietin via an antiapoptotic mechanism on hypoxic-ischemic brain injury in neonatal rats
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Kim MS, Seo YK, Park HJ, Lee KH, Lee KH, Choi EJ, Kim JK, Chung HL, Kim WT
- KMID: 2011554
- Korean J Pediatr.
- 2010 Oct;53(10):898-908.
- doi: 10.3345/kjp.2010.53.10.898
PURPOSE: The neuroprotective effects of erythropoietin (EPO) have been recently shown in many animal models of brain injury, including hypoxic-ischemic (HI) encephalopathy, trauma, and excitotoxicity; however, limited data are available... -
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- Induction of hypoxia-inducible factor-1alpha inhibits drug-induced apoptosis in the human leukemic cell line HL-60
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Yook YJ, Seo YJ, Kang HJ, Ko SH, Shin HY, Lee JJ, Jeong G, Ahn HS
- KMID: 2252055
- Korean J Hematol.
- 2010 Sep;45(3):158-163.
- doi: 10.5045/kjh.2010.45.3.158
BACKGROUND: Leukemic cells originate from hypoxic bone marrow, which protects them from anti-cancer drugs. Although many factors that cause drug resistance in leukemic cells have been studied, the effect of... -
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- The expression of clusterin, bax, p53, Ki-67, and apoptotic index in epithelial ovarian tumors
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Lee JY, Na JY, Kim IS, Park MH, Kang JS
- KMID: 2077998
- Korean J Obstet Gynecol.
- 2010 Sep;53(9):804-815.
- doi: 10.5468/kjog.2010.53.9.804
OBJECTIVE: The purpose of this study was (1) to evaluate the expressions of clusterin, bax, Ki-67, p53, and apoptotic index in epithelial ovarian tumors, borderline and malignant ovarian tumors, (2)... -
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- Transglutaminase 2 inhibits apoptosis induced by calciumoverload through down-regulation of Bax
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Cho SY, Lee JH, Bae HD, Jeong EM, Jang GY, Kim CW, Shin DM, Jeon JH, Kim IG
- KMID: 983956
- Exp Mol Med.
- 2010 Sep;42(9):639-650.
- doi: 10.3858/emm.2010.42.9.063
An abrupt increase of intracellular Ca2+ is observed in cells under hypoxic or oxidatively stressed conditions. The dysregulated increase of cytosolic Ca2+ triggers apoptotic cell death through mitochondrial swelling and... -
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- Retinal Protective Effects of Minocycline via Anti-apoptosis on Oxygen-induced Retinopathy in Neonatal Rats
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Jang YY, Suh ES, Kim WT
- KMID: 2072248
- Korean J Perinatol.
- 2010 Mar;21(1):26-39.
PURPOSE: Retinopathy of prematurity (ROP) is a leading cause of blindness with retinal detachment due to oxygen toxicity in preterm infants. Recently advances in neonatal care had to led improved... -
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- Expression of Bcl-2, Bax and p27 in Patients with Papillary Thyroid Cancer with or without Lymph Node Metastasis
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Lee SJ, Jin SM, Lee SH, Yeo JO, Lee SU, Sohn JH, Chae SW, Kim DH
- KMID: 1455700
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2010 Mar;53(3):153-158.
- doi: 10.3342/kjorl-hns.2010.53.3.153
BACKGROUND AND OBJECTIVES: The aim of this study was to investigate the relationship between the expression of Bcl-2, Bax, p27 and lymph node metastasis (LNM) in papillary thyroid cancer (PTC). SUBJECTS... -
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- Knockdown of RCAN1.4 Increases Susceptibility to FAS-mediated and DNA-damage-induced Apoptosis by Upregulation of p53 Expression
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Kim YS, Lee HJ, Jang C, Kim HS, Cho YJ
- KMID: 2285385
- Korean J Physiol Pharmacol.
- 2009 Dec;13(6):483-489.
- doi: 10.4196/kjpp.2009.13.6.483
Despite the potential importance of the human regulator of calcineurin 1 (RCAN-1) gene in the modulation of cell survival under stress, little is known about its role in death-inducing signal... -
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