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Role of linked color imaging for upper gastrointestinal disease: present and future

Lee SP

Techniques for upper gastrointestinal endoscopy are advancing to facilitate lesion detection and improve prognosis. However, most early tumors in the upper gastrointestinal tract exhibit subtle color changes or morphological features...
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Hybrid argon plasma coagulation in Barrett’s esophagus: a systematic review and meta-analysis

Shah SN, Chehade NEH, Tavangar A, Choi A, Monachese M, Chang KJ, Samarasena JB

Background/Aims: Patients with Barrett’s esophagus are at increased risk of developing esophageal adenocarcinoma. Endoscopic therapies aim to eradicate dysplastic and metaplastic tissues. Hybrid argon plasma coagulation (hybrid-APC) utilizes submucosal fluid...
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Role of artificial intelligence in diagnosing Barrett’s esophagus-related neoplasia

Meinikheim M, Messmann H, Ebigbo A

Barrett’s esophagus is associated with an increased risk of adenocarcinoma. Thorough screening during endoscopic surveillance is crucial to improve patient prognosis. Detecting and characterizing dysplastic or neoplastic Barrett’s esophagus during...
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Safety and long-term efficacy of hybrid-argon plasma coagulation for the treatment of Barrett’s esophagus: An Australian pilot study (with video)

Staudenmann DA, Skacel EP, Tsoutsman T, Kaffes AJ, Saxena P

Background: Five to ten percent of all patients undergoing radiofrequency ablation (RFA), which is the most established technique for Barrett’s esophagus (BE) ablation-develop strictures. Hybrid-argon plasma coagulation (APC) combines APC...
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Distal Esophageal Impedance Measured by High-resolution Esophageal Manometry With Impedance Suggests the Presence of Barrett’s Esophagus

Kataria R, Rosenfeld B, Malik Z, Harrison M, Smith MS, Schey R, Parkman HP

  • KMID: 2504002
  • J Neurogastroenterol Motil.
  • 2020 Jul;26(3):344-351.
  • doi: 10.5056/jnm19105
Background/Aims Barrett’s esophagus (BE) is characterized by intestinal metaplasia in the distal esophagus. The aims of this study are to: (1) Compare baseline distal esophageal impedance (DEI) using high-resolution esophageal...
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Exploring Esophageal Microbiomes in Esophageal Diseases: A Systematic Review

Park CH, Lee SK

  • KMID: 2500675
  • J Neurogastroenterol Motil.
  • 2020 Apr;26(2):171-179.
  • doi: 10.5056/jnm19240
Studies that investigated esophageal microbiomes are limited when compared to those on intestinal microbiomes. Nevertheless, several studies have investigated the relationship between esophageal microbiomes and various esophageal diseases, owing to...
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Endoscopic submucosal dissection in the West

Podboy A, Friedland

Endoscopic resection has emerged as the first line therapy for pre-malignant conditions throughout the gastrointestinal (GI) tract. Resection techniques have evolved from forceps avulsion and snare polypectomy to endoscopic mucosal...
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Diagnosis and Management of Barrett's Esophagus, Dysplasia and Early Esophageal Adenocarcinoma: Focusing on American and European Guidelines

Yoo AY, Joo MK

Barrett's esophagus (BE) is one of the most prominent diseases in Western countries because of its potential to progress to dysplasia or adenocarcinoma. Recently, the American College of Gastroenterology (ACG),...
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Buried Barrett's Esophagus with High-Grade Dysplasia after Radiofrequency Ablation

Castela J, Serrano M, de Ferro S, Pereira DV, Chaves P, Pereira AD

Radiofrequency ablation therapy is an effective endoscopic option for the eradication of Barrett's esophagus that appears to reduce the risk of esophageal cancer. A concern associated with this technique is...
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Esophageal Motor Disorders Are a Strong and Independant Associated Factor of Barrett's Esophagus

Bazin C, Benezech A, Alessandrini M, Grimaud JC, Vitton V

  • KMID: 2413097
  • J Neurogastroenterol Motil.
  • 2018 Apr;24(2):216-225.
  • doi: 10.5056/jnm17090
BACKGROUND/AIMS: Esophageal motor disorder (EMD) has been shown to be associated with gastroesophageal reflux disease (GERD). However, the association of EMD with a Barrett's esophagus (BE) is controversial. Our objective...
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Impact of Obesity on a Chinese Population with Erosive Esophagitis and Barrett's Esophagus

Lee SW, Lien HC, Lee TY, Tung CF, Yeh HZ, Chang CS

BACKGROUND/AIMS: The aim of this study was to investigate the associations between obesity and erosive esophagitis (EE) or Barrett's esophagus (BE) in a Chinese population. METHODS: Data from subjects were retrospectively...
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Laser Imaging Facilitates Early Detection of Synchronous Adenocarcinomas in Patients with Barrett's Esophagus

Iwashita C, Miura Y, Osawa H, Takezawa T, Ino Y, Okada M, Lefor AK, Yamamoto H

Barrett's adenocarcinoma may occur in multiple sites, and recurrence and metachronous lesions are the major problems with endoscopic resection. Therefore, early detection of such lesions is ideal to achieve complete...
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Esophageal Acid Clearance During Random Swallowing Is Faster in Patients with Barrett's Esophagus Than in Healthy Controls

Lottrup C, Krarup AL, Gregersen , Ejstrud P, Drewes AM

  • KMID: 2433455
  • J Neurogastroenterol Motil.
  • 2016 Oct;22(4):630-642.
  • doi: 10.5056/jnm16019
BACKGROUND/AIMS: Impaired esophageal acid clearance may be a contributing factor in the pathogenesis of Barrett’s esophagus. However, few studies have measured acid clearance as such in these patients. In this...
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Sex and Gender Differences in Gastroesophageal Reflux Disease

Kim YS, Kim N, Kim GH

  • KMID: 2433450
  • J Neurogastroenterol Motil.
  • 2016 Oct;22(4):575-588.
  • doi: 10.5056/jnm16138
It is important to understand sex and gender-related differences in gastroesophageal reflux disease (GERD) because gender-related biologic factors might lead to better prevention and therapy. Non-erosive reflux disease (NERD) affects...
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Effect of 15 Minutes Brief Education for Medical Personnel in Diagnosing Barrett's Esophagus

Seo KI, Park MI, Park SJ, Moon W, Kim SE, Han YJ

BACKGROUND/AIMS: The higher prevalence of gastroesophageal reflux disease has preceded the increase of Barrett's esophagus and esophageal adenocarcinoma in Western countries. An increase of Barrett's esophagus and esophageal adenocarcinoma can...
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RING Finger Proteins Are Involved in the Progression of Barrett Esophagus to Esophageal Adenocarcinoma: A Preliminary Study

Wang XW, Wei W, Wang WQ, Zhao XY, Guo H, Fang DC

BACKGROUND/AIMS: To investigate the differential expression of RING finger (RNF) proteins in Barrett esophagus (BE) and esophageal adenocarcinoma (EAC). METHODS: The differential expression of RNFs in normal esophagus (NE), BE, and...
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Barrett's Esophagus and Cancer Risk: How Research Advances Can Impact Clinical Practice

di Pietro , Alzoubaidi D, Fitzgerald RC

  • KMID: 1792358
  • Gut Liver.
  • 2014 Jul;8(4):356-370.
Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC), whose incidence has increased sharply in the last 4 decades. The annual conversion rate of BE to cancer...
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Predictors of Esophageal Stricture Formation Post Endoscopic Mucosal Resection

Qumseya B, Panossian , Rizk C, Cangemi D, Wolfsen C, Raimondo M, Woodward T, Wallace MB, Wolfsen H

BACKGROUND/AIMS: Stricture formation is a common complication after endoscopic mucosal resection. Predictors of stricture formation have not been well studied. METHODS: We conducted a retrospective, observational, descriptive study by using a...
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Treatment of Dysplasia in Barrett Esophagus

Aranda-Hernandez J, Cirocco M, Marcon N

  • KMID: 2165398
  • Clin Endosc.
  • 2014 Jan;47(1):55-64.
Barrett esophagus is recognized as a risk factor for the development of dysplasia and adenocarcinoma of the esophagus. Cancer is usually diagnosed at an advanced stage with a 5-year survival...
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Advanced Imaging Technologies for the Detection of Dysplasia and Early Cancer in Barrett Esophagus

Espino A, Cirocco M, DaCosta R, Marcon N

  • KMID: 2165397
  • Clin Endosc.
  • 2014 Jan;47(1):47-54.
Advanced esophageal adenocarcinomas arising from Barrett esophagus (BE) are tumors with an increasing incidence and poor prognosis. The aim of endoscopic surveillance of BE is to detect dysplasia, particularly high-grade...
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