- Polyphenols isolated from Broussonetia kazinoki prevent cytokine-induced beta-cell damage and the development of type 1 diabetes
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Bae UJ, Jang HY, Lim JM, Hua L, Ryu JH, Park BH
- KMID: 2070279
- Exp Mol Med.
- 2015 Apr;47(4):e160.
- doi: 10.1038/emm.2015.16
The axis of nuclear factor kappaB (NF-kappaB)-inducible NO synthase (iNOS)-nitric oxide plays a key role in cytokine- and streptozotocin-mediated pancreatic beta-cell damage. In this study, we investigated the effects of... -
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- Transplantation of betacellulin-transduced islets improves glucose intolerance in diabetic mice
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Song MY, Bae UJ, Jang KY, Park BH
- KMID: 2155363
- Exp Mol Med.
- 2014 May;46(5):e98.
- doi: 10.1038/emm.2014.24
Type 1 diabetes is an autoimmune disease caused by permanent destruction of insulin-producing pancreatic beta cells and requires lifelong exogenous insulin therapy. Recently, islet transplantation has been developed, and although... -
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- The efficacy of SPA0355 in protecting beta cells in isolated pancreatic islets and in a murine experimental model of type 1 diabetes
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Bae UJ, Song MY, Jang HY, Gim HJ, Ryu JH, Lee SM, Jeon R, Park BH
- KMID: 2154270
- Exp Mol Med.
- 2013 Nov;45(11):e51.
Cytokines activate several inflammatory signals that mediate beta-cell destruction. We recently determined that SPA0355 is a strong anti-inflammatory compound, thus reporting its efficacy in protecting beta cells from various insults.... -
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- SPA0355 attenuates ischemia/reperfusion-induced liver injury in mice
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Bae UJ, Yang JD, Ka SO, Koo JH, Woo SJ, Lee YR, Yu HC, Cho BH, Zhao HY, Ryu JH, Lee SM, Jeon R, Park BH
- KMID: 2155374
- Exp Mol Med.
- 2014 Aug;46(8):e109.
- doi: 10.1038/emm.2014.48
Hepatic ischemia/reperfusion (I/R) injury leads to oxidative stress and acute inflammatory responses that cause liver damage and have a considerable impact on the postoperative outcome. Much research has been performed... -
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