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Single-Center Real-World Experience with Primary Central Nervous System Lymphoma in the 21st Century

Cho H, Hong JY, Lee DH, Kim S, Lee K, Kang EH, Lee S, Park JS, Kim JH, Ryu JS, Huh J, Suh C

Background/Aims: In Korea, the incidence of primary diffuse large B-cell lymphoma of the central nervous system (PCNSL) is increasing and autologous stem cell transplantation (ASCT) has improved the survival of...
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Primary Central Nervous System Lymphoma Mimicking Lacunar Infarction

Shin J, Jeon T, Oh K, Han JH, Kim CK, Lee KJ

Ischemic stroke is a medical emergency that requires precise diagnosis and prompt treatment. Nonetheless, it is essential to evaluate alternative conditions, such as seizure, peripheral neuropathy and malignancy, with special...
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Intracranial Involvement of Systemic Hodgkin Lymphoma: A Case Report and Literature Review

Lee H, Ahn S, Cha SH, Cho WH

A 27-year-old male patient, previously diagnosed with Hodgkin lymphoma (HL), presented with gait disturbance. Brain MRI showed a 4.5 cm mass lesion in the right occipital lobe, suggesting either intracranial...
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Tumor-infiltrating T lymphocytes evaluated using digital image analysis predict the prognosis of patients with diffuse large B-cell lymphoma

Cho Y, Lee J, Han B, Yoon SE, Kim SJ, Kim WS, Cho J

Background: The implication of the presence of tumor-infiltrating T lymphocytes (TIL-T) in diffuse large B-cell lymphoma (DLBCL) is yet to be elucidated. We aimed to investigate the effect of TIL-T...
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Impact of T-Cell Engagers on COVID-19–Related Mortality in B-Cell Lymphoma Patients Receiving B-Cell Depleting Therapy

Lee CM, Choe PG, Kang CK, Jo HJ, Kim NJ, Yoon SS, Kim TM, Park WB, Oh Md

Purpose B-cell depleting therapies, including T-cell engager (TCE), are increasingly used for patients with hematologic malignancies, including during the coronavirus disease 2019 (COVID-19) pandemic. We aimed to evaluate the relationship...
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Taenia saginata infection incidentally detected during workup for lymphoma from an 8-year-old boy in Korea: a case report

Won EJ, Kim MJ, Lee J, Kim H, Sung H, Kim MN

Human taeniasis is presumed to have almost disappeared from Korea. Recently, we incidentally detected a Taenia saginata infection in an 8-year-old boy undergoing lymphoma diagnosis. The patient had been suffering...
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Correlation between red blood cell distribution width/platelet count and prognosis of newly diagnosed diffuse large B-cell lymphoma

Liu X, Bai Y, Liu Y, Li W, Cui Y, Xu J, Xiao X, Niu X, Sun K

Background Red blood cell distribution width/platelet count ratio (RPR) is a reliable prognostic assessment indicator for numerous diseases. However, no studies to date have examined the relationship between RPR and the...
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A Case of Diffuse Large B-cell Lymphoma Transformed from Primary Thyroid MALT Lymphoma

Jo YR, Cho YJ, Pyo JY, Lee HR

Diffuse large B cell lymphoma (DLBCL) is main subtype of primary thyroid lymphoma and can be histologically transformed from a low-grade B-cell lymphoma. The characteristics and treatment guidelines of these...
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Improvement of Severe Colon Stricture after Rituximab Therapy for Concomitant Mucosa-associated Lymphoid Tissue Lymphoma in a Patient with Ulcerative Colitis

Park HJ, Moon W, Park SJ, Park MI, Kim SE, Kim JH, Jung K, Seo KI, Lee EM, Jung M

Colorectal strictures are uncommon in patients with ulcerative colitis (UC). An extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) lymphoma is rarely involved in the colon but may...
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Diffuse Large B-Cell Lymphoma Manifesting as Miliary Nodules in the Lung: A Case Report

Na HJ, Kwon H, Kim SS, Park HK

Malignant lymphoma has various pulmonary manifestations on chest CT, including nodules, masses, areas of consolidation, and ground-glass opacity. These presentations can pose a diagnostic challenge, as they mimic other disease...
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Epstein-Barr Virus Positive Diffuse Large B-Cell Lymphoma with Epidermotropism

Lee GH, Pyo GJ, Myung KB, Kwon ES

Primary cutaneous B-cell lymphomas are rare diseases comprising nodular to diffuse lymphoid cell infiltration with an overlying grenz zone and no epidermal involvement upon histological analysis. Diagnostics can become challenging...
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A Case of Cavernous Sinus Syndrome Due to Extranodal Diffuse Large B-Cell Lymphoma

Kim TR, Bae KN, Son JH, Shin K, Kim H, Ko H, Kim B, Kim MB

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma accounting for approximately one-third of all cases. DLBCL can present as a lymph node or extranodal tumor....
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Identification and overcoming rituximab resistance in diffuse large B-cell lymphoma using next-generation sequencing

Jeon MJ, Yu ES, Choi CW, Kim DS

Background/Aims: Although rituximab, an antiCD20 monoclonal antibody, has dramatically improved the clinical outcomes of diffuse large B-cell lymphoma, rituximab resistance remains a challenge. Methods: We developed a rituximab-resistant cell line (RRCL)...
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Primary diffuse large B-cell lymphoma of the vulva: a case report

Kim SY, Koo JH, Lee J, Koo YJ, Gu MJ, Lee DH

Diffuse large B-cell lymphoma (DLBCL) is a subtype of non-Hodgkin lymphoma (NHL) and is estimated to account for approximately 30% of all NHL cases. NHL can also occur in the...
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Serological response 5 months after the BNT162b2 COVID-19 vaccination in patients with various hematological disorders in Japan

Marumo Y, Yoshida T, Furukawa Y, Ina K, Kamiya A, Kataoka T, Kayukawa S

Purpose Patients with hematological malignancies are at an increased risk of severe infection with coronavirus disease 2019 (COVID-19). However, developing an adequate immune response after vaccination is difficult, especially in patients...
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Long-term Complete Remission of Decitabine-Primed Tandem CD19/CD22 CAR-T Therapy with PD-1 and BTK Inhibitors Maintenance in a Refractory Primary Central Nervous System Lymphoma Patient

Zou R, Zhou X, Liu H, Wang P, Xia F, Kang L, Yu L, Wu D, Jin Z, Qu C

Primary central nervous system lymphoma (PCNSL) is a rare and aggressive non-Hodgkin’s lymphoma that affects the brain, eyes, cerebrospinal fluid, or spinal cord without systemic involvement. The outcome of patients...
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Intensified First Cycle of Rituximab Plus Eight Cycles of Cyclophosphamide, Doxorubicin, Vincristine, and Prednisolone with Rituximab Chemotherapy for Advanced-Stage or Bulky Diffuse Large B-Cell Lymphoma: A Multicenter Phase II Consortium for Improving Survival of Lymphoma (CISL) Study

Kim YR, Kim JS, Kim WS, Eom HS, Yang DH, Bae SH, Kim HJ, Lee JH, Oh SJ, Yoon SS, Kwak JY, Choi CW, Kim MK, Oh SY, Kang HJ, Nam SH, Shim H, Park JS, Mun YC, Suh C, the Korean Society of Hematology Lymphoma Working Party

Purpose This phase II, open-label, multicenter study aimed to investigate the efficacy and safety of a rituximab intensification for the 1st cycle with every 21-day of rituximab, cyclophosphamide, doxorubicin, vincristine, and...
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Unusual case of multifocal cerebral infarction in a patient with gastric mucosa-associated lymphoid tissue lymphoma

Chae HY, Han J, Yum KS, Lee SH, Lee SS, Kim J, Han HS, Shin DI

Mucosa-associated lymphoid tissue (MALT) lymphoma (ML) is a type of non-Hodgkin’s lymphoma involving MALT, commonly the stomach or salivary glands, although virtually any mucosal site can be affected. ML originates from...
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Primary Esophageal Mucosa-associated Lymphoid Tissue Lymphoma: A Rare Case Report and Review of Other Published Data

Bang JH, Kang JH, Kim SH, Park JJ, Lee BJ, Joo MK, Jeon TS

The gastrointestinal tract is the most common extranodal site for lymphomas, and mucosa-associated lymphoid tissue lymphoma is the second most common histological lymphoma subtype. However, primary esophageal mucosa-associated lymphoid tissue...
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Endoscopic Submucosal Dissection for Treatment of Localized Gastric Mucosa-Associated Lymphoid Tissue Lymphoma: A Case Series

Seo Jy, Choi KD, Song IH, Park YS, Na HK, Ahn JY, Lee JH, Jung KW, Kim DH, Song HJ, Lee GH, Jung HY

Background/Aims: The treatment for gastric mucosa-associated lymphoid tissue lymphoma (MALToma) generally involves eradication of Helicobacter pylori. However, MALToma lesions may recur even without H. pylori re-infection. Furthermore, the remission rate...
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