- SNP genetic polymorphisms of MDR-1, CYP1A2 and CYPB11 genes in four canine breeds upon toxicological evaluation
-
Gagliardi , Llambi S, Arruga MV
- KMID: 2344299
- J Vet Sci.
- 2015 Sep;16(3):273-280.
- doi: 10.4142/jvs.2015.16.3.273
The fields of pharmacogenetics and pharmacogenomics have become increasingly promising regarding the clinical application of genetic data to aid in prevention of adverse reactions. Specific screening tests can predict which... -
- CITED
-
- Close
- SHARE
-
- Close
- Future Trends of Helicobacter pylori Eradication Therapy in Korea
-
Lee JY, Kim N
- KMID: 1730927
- Korean J Gastroenterol.
- 2014 Mar;63(3):158-170.
- doi: 10.4166/kjg.2014.63.3.158
The prevalence of Helicobacter pylori infection in Korea shows a decreasing trend and has changed to that of developed country, especially for those below 30 years old. However, the primary... -
- CITED
-
- Close
- SHARE
-
- Close
- Combined effect of CYP1B1, COMT, GSTP1, and MnSOD genotypes and risk of postmenopausal breast cancer
-
Cerne JZ, Pohar-Perme M, Novakovic , Frkovic-Grazio S, Stegel V, Gersak K
- KMID: 2288575
- J Gynecol Oncol.
- 2011 Jun;22(2):110-119.
- doi: 10.3802/jgo.2011.22.2.110
OBJECTIVE: Estrogen plays a key role in breast cancer development and functionally relevant genetic variants within the estrogen metabolic pathway are prime candidates for a possible association with breast cancer... -
- CITED
-
- Close
- SHARE
-
- Close
- Prodrug-activating Gene Therapy with Rabbit Cytochrome P450 4B1/4-Ipomeanol or 2-Aminoanthracene System in Glioma Cells
-
Jang SJ, Kang JH, Lee TS, Kim SJ, Kim KI, Lee YJ, Cheon GJ, Choi CW, Lim SM
- KMID: 1455395
- Nucl Med Mol Imaging.
- 2010 Sep;44(3):193-198.
OBJECTIVE: We determined the cytotoxic properties of cytochrome P450 4B1 (CYP4B1) activated 4-ipomeanol (4-ipo) and 2-aminoanthracene (2-AA) in rat glioma to verify the CYP4B1/4-ipo or 2-AA system for prodrug-activating gene... -
- CITED
-
- Close
- SHARE
-
- Close
- A Case of Intolerance to Warfarin Dosing in an Intermediate Metabolizer of CYP2C9
-
Lee SY, Kim JS, Kim JW
- KMID: 2428302
- Yonsei Med J.
- 2005 Dec;46(6):843-846.
We report a case of intolerance to warfarin dosing due to impaired drug metabolism in a patient heterozygous for the CYP2C9*3 allele. A 30-year-old woman with an artificial cardiac pacemaker... -
- CITED
-
- Close
- SHARE
-
- Close
- A Case Report of a Patient Carrying CYP2C9*3/4 Genotype with Extremely Low Warfarin Dose Requirement
-
Lee SY, Nam MH, Kim JS, Kim JW
- KMID: 1778371
- J Korean Med Sci.
- 2007 Jun;22(3):557-559.
- doi: 10.3346/jkms.2007.22.3.557
We report a case of intolerance to warfarin dosing due to impaired drug metabolism in a patient with CYP2C9*3/*4. A 73-yr-old woman with atrial fibrilation was taking warfarin. She attained... -
- CITED
-
- Close
- SHARE
-
- Close
- Cytochrome P450 2C19 Polymorphism is Associated with Reduced Clopidogrel Response in Cerebrovascular Disease
-
Lee JB, Lee KA, Lee KY
- KMID: 1108064
- Yonsei Med J.
- 2011 Sep;52(5):734-738.
- doi: 10.3349/ymj.2011.52.5.734
PURPOSE: Clopidogrel is a prodrug that requires transformation into an active metabolite by cytochrome P450 (CYP) in the liver in order to irreversibly inhibit the P2Y12 adenosine diphosphate platelet receptor.... -
- CITED
-
- Close
- SHARE
-
- Close
- Association of CYP2C19*2 and *3 Genetic Variants with Essential Hypertension in Koreans
-
Shin DJ, Kwon J, Park AR, Bae Y, Shin ES, Park S, Jang Y
- KMID: 1414252
- Yonsei Med J.
- 2012 Nov;53(6):1113-1119.
- doi: 10.3349/ymj.2012.53.6.1113
PURPOSE: The cytochrome P450 2C19 (CYP2C19) metabolizes arachidonic acid to produce epoxyicosanoid acids, which are involved in vascular tone and regulation of blood pressure. Recent findings suggest that CYP2C19 gene... -
- CITED
-
- Close
- SHARE
-
- Close
- Influence of CYP2C19 Polymorphism and Helicobacter pylori Status on the Antisecretory Effect of Omeprazole in Gastroesophageal Reflux Disease
-
Sohn YH, Lee WS, Park CH, Joo YE, Kim HS, Choi SK, Rew JS, Kim SJ
- KMID: 782759
- Korean J Gastroenterol.
- 2006 Sep;48(3):162-171.
BACKGROUND/AIMS: The acid suppressive effect of omeprazole (OMP) is influenced by the metabolic capacity of gastric acid suppression, which is dependent on CYP2C19 polymorphism. The aim of this study was... -
- CITED
-
- Close
- SHARE
-
- Close
- Efficacy of Triple Therapy with Rabeprazole for Helicobacter pylori Infection in relation to CYP2C19 Genotype
-
Lee SB, Park SJ, Ryu JK, Lee JK, Kim HJ, Bae JS, Jung HS, Park SM
- KMID: 1066037
- Korean J Gastroenterol.
- 2003 Dec;42(6):468-475.
BACKGROUND/AIMS: Genetic polymorphism of cytochrome P450 CYP2C19 influences the efficacy of proton pump inhibitor (PPI) in Helicobacter pylori (H. pylori) eradication therapy. We investigated the difference in the cure... -
- CITED
-
- Close
- SHARE
-
- Close
- Clinical, Pharmacokinetic, and Pharmacogenetic Determinants of Clopidogrel Resistance in Korean Patients with Acute Coronary Syndrome
-
Park KJ, Chung HS, Kim SR, Kim HJ, Han JY, Lee SY
- KMID: 1094346
- Korean J Lab Med.
- 2011 Apr;31(2):91-94.
- doi: 10.3343/kjlm.2011.31.2.91
BACKGROUND: Clopidogrel has been widely used to prevent recurrent ischemia in patients with acute coronary syndrome (ACS). However, inter-individual variability in response to clopidogrel has been a problem in the... -
- CITED
-
- Close
- SHARE
-
- Close
