- Dynamic Regulation of APE1/Ref-1 as a Therapeutic Target Protein
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Choi S, Joo HK, Jeon BH
- KMID: 2164316
- Chonnam Med J.
- 2016 May;52(2):75-80.
- doi: 10.4068/cmj.2016.52.2.75
Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that plays a central role in the cellular response to DNA damage and redox regulation against oxidative stress. APE1/Ref-1 functions in... -
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- Studies on rat liver nuclear DNA damaged by chemical carcinogen (3'-Me DAB) and AP DNA endonuclease. I. Purification and some properties of AP DNA endonucleases in rat liver chromatin
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Kim YS, Kim JW, Lee SE, Oh SH
- KMID: 1421490
- J Korean Med Sci.
- 1990 Sep;5(3):127-135.
- doi: 10.3346/jkms.1990.5.3.127
Three kinds of apurinic/apyrimidinic (AP) DNA endonuclease, APcI, APcII, APcIII, were purified from rat liver chromatin through 1M KCl extraction, DEAE-trisacryl ion exchange chromatography. Sephadex G-150 gel filtration and AP... -
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- Studies on rat liver nuclear DNA damaged by chemical carcinogen (3'-Me DAB) and AP DNA endonuclease. II. Kinetic properties of AP DNA endonucleases in rat liver chromatin
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Kim YS, Kim JW, Lee SE, Oh SH
- KMID: 1421491
- J Korean Med Sci.
- 1990 Sep;5(3):137-143.
- doi: 10.3346/jkms.1990.5.3.137
An experiment was designed to investigate the reaction mechanism of AP (apurinic or apyrimidinic) DNA endonucleases (APcI, APcII, APcIII) purified from rat liver chromatin. Sulfhydryl compounds (2-mercaptoethanol, dithiothreitol) brought about... -
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- APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions
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Thakur S, Sarkar B, Cholia RP, Gautam N, Dhiman M, Mantha AK
- KMID: 2155371
- Exp Mol Med.
- 2014 Jul;46(7):e106.
- doi: 10.1038/emm.2014.42
Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional enzyme involved in the base excision repair (BER) pathway, which repairs oxidative base damage caused by endogenous and exogenous agents. APE1 acts as... -
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- Site-Specific Mutagenesis in Escherichia coli by Bulky Exocyclic Amino-Substituted Guanine and Adenine Derivatives in Double-Stranded or Gapped Plasmids
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Moon KY
- KMID: 1807225
- Cancer Res Treat.
- 2003 Feb;35(1):75-80.
PURPOSE: 7-Bromomethylbenz[alpha]anthracene is a known mutagen and carcinogen. The mutagenic potency of its two major DNA adducts, i.e., N2-(benz[alpha]anthracen-7-ylmethyl)-2'-deoxyguanosine (b[alpha]a2G) and N6-(benz[alpha]anthracen-7-ylmethyl)-2'-deoxyadenosine (b[alpha]a6A), as well as the simpler benzylated analogs,... -
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